遺伝子座決定

WordNet

a point or extent in space
a workplace away from a studio at which some or all of a movie may be made; "they shot the film on location in Nevada"
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

PrepTutorEJDIC

〈U〉(…の)位置(場所)を捜し出すこと《+『of』+『名』》 / 〈C〉『位置』,場所 / 〈C〉(映画などの)『野外撮影地』;〈U〉ロケーション
遺伝子

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/22 12:01:39」(JST)

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Short and long arms

Chromosome components:

(1) Chromatid
(2) Centromere
(3) Short (p) arm

(4) Long (q) arm

Example of bands

In the fields of genetics and genetic computation, a locus (plural loci) is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map. Gene mapping is the procession of determining the locus for a particular biological trait.

Diploid and polyploid cells whose chromosomes have the same allele of a given gene at some locus are called homozygous with respect to that gene, while those that have different alleles of a given gene at a locus, are called heterozygous with respect to that gene.

Nomenclature

The chromosomal locus of a gene might be written "6p21.3".

Component	Explanation
6	The chromosome number.
p	The position is on the chromosome's short arm (p for petit in French); q indicates the long arm (chosen as next letter in alphabet after p).
21.3	The numbers that follow the letter represent the position on the arm: region 2, band 1, sub-band 3. The bands are visible under a microscope when the chromosome is suitably stained. Each of the bands is numbered, beginning with 1 for the band nearest the centromere. Sub-bands and sub-sub-bands are visible at higher resolution.

A range of locales is specified in a similar way. For example, the locus of gene OCA1 may be written "11q1.4-q2.1", meaning it is on the long arm of chromosome 11, somewhere in the range from sub-band 4 of band 1, and sub-band 1 of band 2.

The ends of a chromosome are labeled "pter" and "qter", and so "2qter" refers to the telomere of the long arm of chromosome 2.

Centisome

A centisome is defined as 1% of a chromosome length.^[1]

References

^ http://www.ai.sri.com/pkarp/pubs/93ismb.pdf

External links

Overview at ornl.gov

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English Journal

Molecular cloning, characterization and expression of myoglobin in Tibetan antelope (Pantholops hodgsonii), a species with hypoxic tolerance.

Ma L, Shao X, Wang Y, Yang Y, Bai Z, Zhao Y, Jin G, Ga Q, Yang Q, Ge RL.SourceResearch Center for High Altitude Medicine, Qinghai University Medical College, Xining 810001, Qinghai, China.
Gene.Gene.2014 Jan 10;533(2):532-7. doi: 10.1016/j.gene.2013.09.030. Epub 2013 Sep 26.
The Tibetan antelope (Pantholops hodgsonii) is a hypoxia-tolerant species that lives at an altitude of 4000-5000m above sea level on the Qinghai-Tibetan plateau. Myoglobin is an oxygen-binding cytoplasmic hemoprotein that is abundantly expressed in oxidative skeletal and cardiac myocytes. Numerous s
PMID 24076356

A photo-degradable gene delivery system for enhanced nuclear gene transcription.

Lee H, Kim Y, Schweickert PG, Konieczny SF, Won YY.SourceSchool of Chemical Engineering, Purdue University, West Lafayette, IN 47907, United States.
Biomaterials.Biomaterials.2014 Jan;35(3):1040-9. doi: 10.1016/j.biomaterials.2013.10.030. Epub 2013 Oct 27.
There currently exists a significant gap in our understanding of how the detailed chemical characteristics of polycation gene carriers influence their delivery performances in overcoming an important cellular-level transport barrier, i.e., intranuclear gene transcription. In this study, a UV-degrada
PMID 24172855

Mutational spectrum of Xeroderma pigmentosum group A in Egyptian patients.

Amr K, Messaoud O, El Darouti M, Abdelhak S, El-Kamah G.SourceMedical Molecular Genetics Department, Human Genetics & Genome Research Division, National Research Center, Cairo, Egypt.
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Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disease characterized by hyperphotosensitivity, DNA repair defects and a predisposition to skin cancers. The most frequently occurring type worldwide is the XP group A (XPA). There is a close relationship between the clinical featur
PMID 24135642

Japanese Journal

Stem Cell Informatics Database:多様なヒト細胞情報の統合化を目指したデータベースの構築

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Biallelic Disruption of the PTCH1 Gene in Multiple Basal Cell Carcinomas in Japanese Patients with Nevoid Basal Cell Carcinoma Syndrome

Tate Genshu,Kishimoto Koji,Mitsuya Toshiyuki
Acta Medica Okayama 68(3), 163-170, 2014-06
… Of particular note is that all BCC specimens examined showed a loss of the wild-type allele of exon 16 in PTCH1, thus indicating that LOH results in the biallelic disruption of PTCH1 in multiple BCCs that develop in an age- and location-independent manner in the same patient. …
NAID 120005447129