gene expression

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遺伝子発現

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/03 11:59:42」(JST)

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英文文献

  • Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress.
  • Larson JK, Carvan MJ 3rd, Teeguarden JG, Watanabe G, Taya K, Krystofiak E, Hutz RJ.Author information University of Wisconsin-Milwaukee, Biological Sciences , Milwaukee, WI , USA.AbstractAbstract Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on progesterone and estradiol-17β accumulation by rat ovaries ex vivo and (2) to identify the locus/loci whereby GNPs modulate steroidogenesis via multiple-reference gene quantitative real-time RT-PCR. Regression analyses indicated a positive relationship between both Star (p < 0.05, r(2) = 0.278) and Cyp11a1 (p < 0.001, r(2) = 0.366) expression and P4 accumulation upon exposure to 1.43 × 10(6) GNPs/mL. Additional analyses showed that E2 accumulation was positively associated with Hsd3b1 (p < 0.05, r(2) = 0.181) and Cyp17a1 (p < 0.01, r(2) = 0.301) expression upon exposure to 1.43 × 1(3) and 1.43 × 10(9) GNPs/mL, respectively. These results suggest a subtle treatment-dependent impact of low-dose GNPs on the relationship between progesterone or estradiol-17β and specific steroidogenic target genes, independent of oxidative stress or inhibin.
  • Nanotoxicology.Nanotoxicology.2014 Dec;8:856-66. doi: 10.3109/17435390.2013.837208.
  • Abstract Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on progesterone and estradiol-
  • PMID 23992423
  • Chlamydial biology and its associated virulence blockers.
  • Beeckman DS, De Puysseleyr L, De Puysseleyr K, Vanrompay D.Author information Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University , Coupure Links 653, B-9000 Ghent , Belgium.AbstractAbstract Chlamydiales are obligate intracellular parasites of eukaryotic cells. They can be distinguished from other Gram-negative bacteria through their characteristic developmental cycle, in addition to special biochemical and physical adaptations to subvert the eukaryotic host cell. The host spectrum includes humans and other mammals, fish, birds, reptiles, insects and even amoeba, causing a plethora of diseases. The first part of this review focuses on the specific chlamydial infection biology and metabolism. As resistance to classical antibiotics is emerging among Chlamydiae as well, the second part elaborates on specific compounds and tools to block chlamydial virulence traits, such as adhesion and internalization, Type III secretion and modulation of gene expression.
  • Critical reviews in microbiology.Crit Rev Microbiol.2014 Nov;40(4):313-28. doi: 10.3109/1040841X.2012.726210. Epub 2012 Nov 7.
  • Abstract Chlamydiales are obligate intracellular parasites of eukaryotic cells. They can be distinguished from other Gram-negative bacteria through their characteristic developmental cycle, in addition to special biochemical and physical adaptations to subvert the eukaryotic host cell. The host spec
  • PMID 23134414
  • Iron oxide nanoparticle agglomeration influences dose rates and modulates oxidative stress-mediated dose-response profiles in vitro.
  • Sharma G, Kodali V, Gaffrey M, Wang W, Minard KR, Karin NJ, Teeguarden JG, Thrall BD.Author information Battelle Memorial Institute , Columbus, OH , USA.AbstractAbstract Spontaneous agglomeration of engineered nanoparticles (ENPs) is a common problem in cell culture media which can confound interpretation of in vitro nanotoxicity studies. The authors created stable agglomerates of iron oxide nanoparticles (IONPs) in conventional culture medium, which varied in hydrodynamic size (276 nm-1.5 μm) but were composed of identical primary particles with similar surface potentials and protein coatings. Studies using C10 lung epithelial cells show that the dose rate effects of agglomeration can be substantial, varying by over an order of magnitude difference in cellular dose in some cases. Quantification by magnetic particle detection showed that small agglomerates of carboxylated IONPs induced greater cytotoxicity and redox-regulated gene expression when compared with large agglomerates on an equivalent total cellular IONP mass dose basis, whereas agglomerates of amine-modified IONPs failed to induce cytotoxicity or redox-regulated gene expression despite delivery of similar cellular doses. Dosimetry modelling and experimental measurements reveal that on a delivered surface area basis, large and small agglomerates of carboxylated IONPs have similar inherent potency for the generation of ROS, induction of stress-related genes and eventual cytotoxicity. The results suggest that reactive moieties on the agglomerate surface are more efficient in catalysing cellular ROS production than molecules buried within the agglomerate core. Because of the dynamic, size and density-dependent nature of ENP delivery to cells in vitro, the biological consequences of agglomeration are not discernible from static measures of exposure concentration (μg/ml) alone, highlighting the central importance of integrated physical characterisation and quantitative dosimetry for in vitro studies. The combined experimental and computational approach provides a quantitative framework for evaluating relationships between the biocompatibility of nanoparticles and their physical and chemical characteristics.
  • Nanotoxicology.Nanotoxicology.2014 Sep;8:663-75. doi: 10.3109/17435390.2013.822115. Epub 2013 Jul 31.
  • Abstract Spontaneous agglomeration of engineered nanoparticles (ENPs) is a common problem in cell culture media which can confound interpretation of in vitro nanotoxicity studies. The authors created stable agglomerates of iron oxide nanoparticles (IONPs) in conventional culture medium, which varied
  • PMID 23837572

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Gene Expression By Razib Khan ~~set title~~ By ~~raw authors~~ ~~set abstract~~ Read Full | ~~{render.allowRemove~~ Remove | ~~}~~ Published ~~set pub~~ | ~~set comments~~ No articles in this publication To add ...
Gene expression profiling simultaneously compares the expression levels of many genes between two or more sample types. This analysis can help scientists identify the molecular basis for phenotypic differences and ...

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リンク元遺伝子発現
拡張検索gene expression profiling
関連記事expression」「gene」「gen

遺伝子発現」

  [★]

gene expression
遺伝情報発現 genetic information expression形質発現 manifestation表現型発現 phenotypic expression
転写後調節発現調節



gene expression profiling」

  [★]

gene expression profiletranscriptome


expression」

  [★]

  • n.
Eq.equationexertexpressfacial expressionformulaformulaelevel of expressionmanifestationrepresentrepresentationrepresentational

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「(genetics) the process of expressing a gene」

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「the feelings expressed on a person''s face; "a sad expression"; "a look of triumph"; "an angry face"」
look, aspect, facial expression, face

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「the act of forcing something out by squeezing or pressing; "the expression of milk from her breast"」

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「expression without words; "tears are an expression of grief"; "the pulse is a reflection of the heart''s condition"」
manifestation, reflection, reflexion

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「the communication (in speech or writing) of your beliefs or opinions; "expressions of good will"; "he helped me find verbal expression for my ideas"; "the idea was immediate but the verbalism took hours"」
verbal expression, verbalism

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「〈U〉〈C〉(思想・意見・考えなどを)『言葉で表すこと』,(…の)『表現』《+『of』+『名』》 / 〈C〉(考え・気持ちなどの)『現れ』,印《+『of』+『名』》 / 〈C〉(考え・気持ちなどを表す)『顔つき』,表情《+『of』+『名』》 / 〈U〉(考え・気持ちなどを表す)声の調子 / 〈C〉語句,言い回し,表現法 / 〈C〉(数量・運算などを示す)式」


gene」

  [★] 遺伝子

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「(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"」
cistron, factor

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「遺伝子」

gen」

  [★]

WordNet   license wordnet

「informal term for information; "give me the gen on your new line of computers"」




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