gene dosage

WordNet

1. (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
2. informal term for information; "give me the gen on your new line of computers"

PrepTutorEJDIC

1. 遺伝子
2. 〈C〉《通例a~》1回分の投薬量 / 〈U〉《まれ》投薬

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/09 05:35:56」(JST)

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[Wiki en表示]

Gene dosage is the number of copies of a particular gene present in a genome. Gene dosage is known to be related to the amount of gene product the cell is able to express, however, amount of gene product produced in a cell is more commonly dependent on regulation of gene expression. Nonetheless, changes in gene dosage (copy number variations) due to gene insertions or deletions can have significant phenotypic consequences.

Most genes found in the cell are expressed as autosomal genes (see autosome) and are found in two copies, alterations to this two-copy gene dosage is significantly associated with quantitative or qualitative phenotype traits and is linked to many genetic health problems such as those associated with Down Syndrome. In Down Syndrome, the gene expression on chromosome 21 has increased 50%, and this results in significant health and mental disabilities (1 in 800 human live births have Down Syndrome).

See also

• Copy-number variation
• Dosage compensation
• Genetic association
• Polyploidy, Aneuploidy

References

UpToDate Contents

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English Journal

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• Topical dura mater application of CFA induces enhanced expression of c-fos and glutamate in rat trigeminal nucleus caudalis: attenuated by KYNA derivate (SZR72).

• Lukács M1,2, Warfvinge K3,4, Tajti J5, Fülöp F6, Toldi J7,8, Vécsei L5,8, Edvinsson L3,4.
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Japanese Journal

• 琉球石灰岩帯水層における脱窒に係わる微生物相解析

• 安元 純,廣瀬（安元） 美奈,久手堅 剛 [他],宮城 雄次,大城 要平,聖川 健斗,細野 高啓,嶋田 純,中野 拓治
• 地下水学会誌 57(2), 153-169, 2015
• 本研究では，沖縄本島南部地域の琉球石灰岩帯水層において，地下水水質データと硝酸中の窒素及び酸素同位体比（δ15NNO3，δ18ONO3）を測定することで脱窒ポイントを推定し，PCR法を組み合わせた変性剤濃度勾配ゲル電気泳動法（以下，PCR-DGGE法）及びリアルタイムPCR等を用いた微生物相解析等を実施して，帯水層中の優占種および分離菌株の分子系統解析と脱窒関連遺伝子の検出と定量を試みると共に，そ …
• NAID 130005083920

• Cytotoxic Effects and Androgen Receptor Expression According to Concentrations of Genistein with Silencing Cyclooxygenase–2 Gene Expression in Prostate Cancer Cells

• Kim Jin Woo,Gotoh Takafumi,Lim Hyoun–Sub,Song Ki Hak,Sul Chong Koo
• Journal of the Faculty of Agriculture, Kyushu University 59(2), 289-296, 2014-08-29
• … The mRNA expression of AR was down–regulated in DU–145 cell line according to concentration of genistein, but caspase–3 expression showed up–regulated pattern in increasing the dosage of genistein. …
• NAID 120005472175

Related Links

• gene dosage - 日本語翻訳 – Linguee辞書

"gene dosage"の翻訳を提案する コピーする Lingueeについて Linguee in English ログイン フィードバック JA-EN 辞書 英語-日本語 gene — 遺伝子 · ジーン · いでんいんし · ゲン · いでんし ...

• Gene dosage effects: nonlinearities, genetic interactions, and ...

1. Trends Genet. 2013 Jul;29(7):385-93. doi: 10.1016/j.tig.2013.04.004. Epub 2013 May 17. Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation. Veitia RA(1), Bottani S, Birchler JA. Author ...

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★リンクテーブル★

リンク元	「遺伝子量」「gene copy number」
関連記事	「dosage」

「遺伝子量」

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英

gene dosage

関

遺伝子コピー数

「gene copy number」

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• 遺伝子コピー数

関

gene dosage

「dosage」

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• 薬用量、投与量、服用量、用量、投薬量、製剤

関

dose、drug product、formulation、ID、injected dose、input、preparation、therapeutic dose