gene-directed enzyme prodrug therapy

出典: meddic

遺伝子指向性酵素プロドラッグ療法遺伝子指向性酵素プロドラッグ治療

GDEPT

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英文文献

  • Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
  • Amara I1, Touati W1, Beaune P1, de Waziers I2.
  • Biochimie.Biochimie.2014 Jun 27. pii: S0300-9084(14)00169-2. doi: 10.1016/j.biochi.2014.06.016. [Epub ahead of print]
  • Gene-directed enzyme prodrug therapy (GDEPT) consists of targeted delivery to tumor cells of a suicide gene responsible for the in situ conversion of a prodrug into cytotoxic metabolites. One of the major impediments of GDEPT is to target specifically the tumor cells with the suicide gene. Among gen
  • PMID 24977933
  • Percutaneous bone cement refixation of aseptically loose hip prostheses: the effect of interface tissue removal on injected cement volumes.
  • Malan DF1, Valstar ER, Nelissen RG.
  • Skeletal radiology.Skeletal Radiol.2014 Jun 7. [Epub ahead of print]
  • OBJECTIVE: To quantify whether injected cement volumes differed between two groups of patients who underwent experimental minimally invasive percutaneous cement injection procedures to stabilize aseptically loose hip prostheses. One patient group was preoperatively treated using gene-directed enzyme
  • PMID 24906460
  • Targeted delivery of CYP2E1 recombinant adenovirus to malignant melanoma by bone marrow-derived mesenchymal stem cells as vehicles.
  • Wang J1, Ma D, Li Y, Yang Y, Hu X, Zhang W, Fang Q.
  • Anti-cancer drugs.Anticancer Drugs.2014 Mar;25(3):303-14. doi: 10.1097/CAD.0000000000000046.
  • The aim of this study was to explore the effects of bone marrow-derived mesenchymal stem cells (BMSCs) as intermediate carriers on targeting of P450 gene recombinant adenovirus to malignant melanoma in vitro and in vivo. BMSCs were transduced with pAd5-CMV-CYP2E1 recombinant adenovirus. BMSC migrati
  • PMID 24413391

和文文献

  • (4)変異型単純ヘルペスウイルス(HSV)を用いた卵巣癌に対する治療戦略 : 新規がんウイルス療法の開発と構築を目指して(<特集>第61回学術講演会シンポジウム3「卵巣癌の新たな治療戦略-基礎から,そして臨床から-」)
  • 那波 明宏
  • 日本産科婦人科學會雜誌 61(11), 2054-2070, 2009-11-01
  • … After cytoreductive surgery, advanced-stage epithelialovarian carcinoma (EOC) initially appears chemotherapy sensitive, as response rates to platinum-based therapy exceed 80%. … To achieve success in cancer therapy for solid tumors, a maximal oncolytic effect is required; … The survival of mice treated with a high titer hrR3 (5×10^7pfu), which has replaced the gene of UL39 with the lac Z, was significant prolonged as compared with the group given paclitaxel (p<0.0001, log lank test). …
  • NAID 110007467576
  • Gene directed enzyme/prodrug therapy of cancer : historical appraisal and future prospectives

関連リンク

Gene-directed enzyme prodrug therapy (GDEPT) is a two step gene therapy approach where the gene for a non-endogenous enzyme is directed to target tissues. The e ... Gene-directed enzyme prodrug therapy (GDEPT): choice of ...
As one targeting strategy of prodrug delivery, gene-directed enzyme prodrug therapy (GDEPT) promises to realize the targeting through its three key features in cancer therapy—cell-specific gene delive

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★リンクテーブル★
リンク元遺伝子指向性酵素プロドラッグ療法」「遺伝子指向性酵素プロドラッグ治療」「GDEPT
関連記事direct」「therapy」「gene」「directed」「enzyme

遺伝子指向性酵素プロドラッグ療法」

  [★]

gene-directed enzyme prodrug therapyGDEPT
遺伝子指向性酵素プロドラッグ治療


遺伝子指向性酵素プロドラッグ治療」

  [★]

gene-directed enzyme prodrug therapy
遺伝子指向性酵素プロドラッグ療法

GDEPT」

  [★]

gene-directed enzyme prodrug therapy

direct」

  [★]

  • adj.
  • 直接の、直接的な、直接型の、ダイレクトな
  • v.
  • 指示する、向ける、指揮する、方向づける、指導する、配向する
coachconductdictatedirectiondirectlyguidanceguideimmediateindicateindicationinstructinstructionorientorientationpointstraightforwardtutorial

WordNet   license wordnet

「straightforward in means or manner or behavior or language or action; "a direct question"; "a direct response"; "a direct approach"」

PrepTutorEJDIC   license prepejdic

「『まっすぐな』,一直線の(straight),直進する / (列車などが途中駅に寄らずに)直行 / 直系の / 『直接の』,じかの / 『率直な』,単刀直入の / 全くの,絶対の / 原典どおりの / 『まっすぐに』,直行で / 〈事〉‘を'『指揮する』,監督する / 《文》〈人〉‘に'『命令する』,指図する / 〈人〉‘に'(…への)『道を教える』《+『名』〈人〉+『to』+『名』》 / (…に)〈目・注意・努力など〉‘を'『向ける』《+『名』+『to』(『at, toward』)+『名』(do『ing』)》 / 〈音楽・演劇・映画など〉‘を'『指揮する』,演出する,監督する / (…に)〈手紙など〉‘を'あてる《+『名』+『to』+『名』》」

WordNet   license wordnet

「having no intervening persons, agents, conditions; "in direct sunlight"; "in direct contact with the voters"; "direct exposure to the disease"; "a direct link"; "the direct cause of the accident"; "direct vote"」
unmediated

WordNet   license wordnet

「in precisely the same words used by a writer or speaker; "a direct quotation"; "repeated their dialog verbatim"」
verbatim

WordNet   license wordnet

「(of a current) flowing in one direction only; "direct current"」

WordNet   license wordnet

「be in charge of」

WordNet   license wordnet

「being an immediate result or consequence; "a direct result of the accident"」

WordNet   license wordnet

「command with authority; "He directed the children to do their homework"」

WordNet   license wordnet

「direct in spatial dimensions; proceeding without deviation or interruption; straight and short; "a direct route"; "a direct flight"; "a direct hit"」

WordNet   license wordnet

「give directions to; point somebody into a certain direction; "I directed them towards the town hall"」

WordNet   license wordnet

「guide the actors in (plays and films)」

WordNet   license wordnet

「lacking compromising or mitigating elements; exact; "the direct opposite"」

WordNet   license wordnet

「moving from west to east on the celestial sphere; or--for planets--around the sun in the same direction as the Earth」

WordNet   license wordnet

「similar in nature or effect or relation to another quantity; "a term is in direct proportion to another term if it increases (or decreases) as the other increases (or decreases)"」

therapy」

  [★]

  • n.
carecurecuringpracticepsychotherapyregimenremediationremedytherapeutictreattreatmenttreatment protocol

WordNet   license wordnet

「(medicine) the act of caring for someone (as by medication or remedial training etc.); "the quarterback is undergoing treatment for a knee injury"; "he tried every treatment the doctors suggested"; "heat therapy gave the best relief"」

PrepTutorEJDIC   license prepejdic

「(病気の)治療,療法 / =psychotherapy」


gene」

  [★] 遺伝子

WordNet   license wordnet

「(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"」
cistron, factor

PrepTutorEJDIC   license prepejdic

「遺伝子」

directed」

  [★]

  • n.

WordNet   license wordnet

「manageable by a supervising agent; "a directed program of study"」

WordNet   license wordnet

「(often used in combination) having a specified direction; "a positively directed vector"; "goal-directed"」

enzyme」

  [★] 酵素

WordNet   license wordnet

「any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions」

PrepTutorEJDIC   license prepejdic

「酵素」



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