WordNet
- use a shift key on a keyboard; "She could not shift so all her letters are written in lower case"
- the time period during which you are at work (同)work shift, duty period
- the act of moving from one place to another; "his constant shifting disrupted the class" (同)shifting
- an event in which something is displaced without rotation (同)displacement
- a crew of workers who work for a specific period of time
- change place or direction; "Shift ones position" (同)dislodge, reposition
- change gears; "you have to shift when you go down a steep hill"
- change in quality; "His tone shifted"
- change phonetically as part of a systematic historical change; "Grimm showed how the consonants shifted"
- move and exchange for another; "shift the date for our class reunion"
- move from one setting or context to another; "shift the emphasis"; "shift ones attention"
- continuously varying; "taffeta with shifting colors"
- changing position or direction; "he drifted into the shifting crowd"; "their nervous shifting glances"; "shifty winds" (同)shifty
- (of soil) unstable; "shifting sands"; "unfirm earth" (同)unfirm
- the quality of moving freely
- a colloid in a more solid form than a sol (同)colloidal gel
- become a gel; "The solid, when heated, gelled"
- cut off the testicles (of male animals such as horses); "the vet gelded the young horse" (同)cut
PrepTutorEJDIC
- 〈人・場所・位置など〉‘を'『移し替える』,置き換える / …‘を'変える,取り替える / 〈自動車のギヤ〉‘を'入れ変える / (…へ)『変わる』,移る《+『to』+『名』》 / 車のギヤを変える;〈車が〉ギヤが入れ変わる・『変換』,転換;移動 / (仕事、作業の)『交替』,交替製;交替の組(人);交替時間 / (特に,自動車)変速装置 / やりくり[算段],一時しのぎの手段,便法;ずるい手段,策略 / シフトドレス(肩から腰までまっすぐした線のゆったりしたワンピース);スリップ
- 可動性,流動性,変わりやすさ;(軍隊の)機動力
- ゲル(コロイド溶液の凝固した状態;ゼラチン・寒天など) / =jell
- 〈動物,特に馬〉‘を'去勢する
UpToDate Contents
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- 1. 熱傷後のケロイドおよび肥厚性瘢痕のマネージメント management of keloid and hypertrophic scars following burn injuries
- 2. 高齢者における転倒：危険因子および患者評価 falls in older persons risk factors and patient evaluation
- 3. 褥瘡の予防 prevention of pressure ulcers
- 4. 成人における術後の腹膜癒着とその予防 postoperative peritoneal adhesions in adults and their prevention
- 5. 糖尿病における関節可動域の制限 limited joint mobility in diabetes mellitus
English Journal
- A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins.
- Berndsen CE, Wolberger C.SourceDepartment of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute and the Johns Hopkins University School of Medicine, Baltimore, MD 21202, USA.
- Analytical biochemistry.Anal Biochem.2011 Nov 1;418(1):102-10. Epub 2011 Jul 2.
- Ubiquitination is a widely studied regulatory modification involved in protein degradation, DNA damage repair, and the immune response. Ubiquitin is conjugated to a substrate lysine in an enzymatic cascade involving an E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and an E3 ubi
- PMID 21771579
- In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules.
- Jindal E, Goswami SK.AbstractDepending on the dose, norepineprine (NE) can induce hypertrophy or apoptosis in cardiac myocytes. Reactive oxygen species (ROS) play a key role in mediating both responses, but the mechanisms are not understood as yet. Earlier we demonstrated that the two pathways are marked by the differential induction of FosB and Fra-1, two members of the AP-1 family of transcription factors. We now demonstrate that NE induces both fosB and fra-1 at the transcriptional level. Catalase and MnTMPyP (a superoxide dismutase mimetic) suppress their activation by NE. In contrast, in cells without NE treatment, MnTMPyP upregulates their expression, whereas catalase inhibits it. Thus, regulation of fosB and fra-1 by ROS is context specific. To delineate the mechanisms, the 1493- and 2689-bp upstream regions of the fosB and fra-1 genes were cloned into the luciferase vector and assayed for transient expression. Catalase and MnTMPyP regulated both promoters the same as their endogenous counterparts in NE-treated and untreated cells. Deletion, mutation, and ChIP analyses suggested that multiple cis-elements including SP-1, CEBP, and AP-1 in the fosB promoter make discrete contributions to mediating the redox response. A gel mobility-shift-based oxidation-reduction assay suggested that, whereas SP-1 is a direct sensor of cellular redox state, CEBP is not. This study suggests that multiple redox signals generate gene-specific modules affecting their expression.
- Free radical biology & medicine.Free Radic Biol Med.2011 Oct 15;51(8):1512-21. Epub 2011 Jul 19.
- Depending on the dose, norepineprine (NE) can induce hypertrophy or apoptosis in cardiac myocytes. Reactive oxygen species (ROS) play a key role in mediating both responses, but the mechanisms are not understood as yet. Earlier we demonstrated that the two pathways are marked by the differential ind
- PMID 21820506
Japanese Journal
- Oligomerization and DNA-Binding Capacity of Pmr, a Histone-Like Protein H1 (H-NS) Family Protein Encoded on IncP-7 Carbazole-Degradative Plasmid pCAR1
- SUZUKI Chiho,YUN Choong-Soo,UMEDA Takashi,TERABAYASHI Tsuguno,WATANABE Kazuya,YAMANE Hisakazu,NOJIRI Hideaki
- Bioscience, Biotechnology, and Biochemistry 75(4), 711-717, 2011
- … To clarify the mode of function of Pmr, we performed gel filtration chromatography analysis and protein-protein cross-linking, and found that Pmr forms homo-oligomers, consisting of its homodimers. … Additionally, evaluating protein-DNA affinity is important to clarify the mode of function of Pmr, and hence we performed an electrophoretic mobility shift assay. …
- NAID 130000645292
- X-Ray Crystal Structure of the DNA-Binding Domain of Response Regulator WalR Essential to the Cell Viability of Staphylococcus aureus and Interaction with Target DNA
- DOI Akihiro,OKAJIMA Toshihide,GOTOH Yasuhiro,TANIZAWA Katsuyuki,UTSUMI Ryutaro
- Bioscience, biotechnology, and biochemistry 74(9), 1901-1907, 2010-09-23
- … Gel mobility shift assays with mutant WalRs revealed specific interactions of WalR with the target DNA, as elaborated by in silico modeling of the WalRc-DNA complex. …
- NAID 10027559722
Related Links
- An electrophoretic mobility shift assay (EMSA) or mobility shift electrophoresis, also referred as a gel shift assay, gel mobility shift assay, band shift assay, or gel retardation assay, is a common affinity electrophoresis technique used to study ...
Related Pictures
★リンクテーブル★
| リンク元 | 「gel shift」「ゲルシフト」「ゲル移動度シフト」 |
| 拡張検索 | 「gel mobility shift assay」 |
| 関連記事 | 「shift」「mobility」「g」 |
「gel shift」
「ゲルシフト」
「ゲル移動度シフト」
「gel mobility shift assay」
「shift」
- n.
- v.
- 変化する、移動する、変わる
- 関
- alter、alteration、alternate、change、changeover、conversion、convert、diversion、entry、immigration、interconversion、migrate、move、movement、replacement、run、switch、switching、transfer、transit、transition、transitional、translocate、translocation、travel、turn、turn to、variation、variational、vary
「mobility」
- n.
「g」
- 関
- gram