ガングリオシドガラクトシル転移酵素、ガングリオシドガラクトシルトランスフェラーゼ
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/28 22:57:05」(JST)
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| ganglioside galactosyltransferase |
| Identifiers |
| EC number |
2.4.1.62 |
| CAS number |
37217-28-0 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a ganglioside galactosyltransferase (EC 2.4.1.62) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
The 2 substrates of this enzyme are UDP-galactose and N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine, whereas its 2 products are UDP and D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galac tosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase. Other names in common use include UDP-galactose-ceramide galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl), galactosyl-glucosyl-ceramide galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, and GM1-synthase. This enzyme participates in glycosphingolipid biosynthesis - ganglioseries and glycan structures - biosynthesis 2.
References
- Basu S, Kaufman B, Roseman S (1965). "Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase". J. Biol. Chem. 240 (10): 4115–7. PMID 5842076.
- Yip GB, Dain JA (1970). "The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceram ide galactosyltransferase in rat brain". Biochim. Biophys. Acta 206 (2): 252–60. doi:10.1016/0005-2744(70)90108-7. PMID 4987145.
- Yip MC, Dain JA (1970). "Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosy lceram ide galactosyltransferase". Biochem. J. 118 (2): 247–52. PMC 1179110. PMID 5484669.
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Transferases: glycosyltransferases (EC 2.4)
|
|
2.4.1: Hexosyl-
transferases |
| Glucosyl- |
- Phosphorylase
- Glycogen synthase
- Debranching enzyme
- Branching enzyme
- 1,3-Beta-glucan synthase
- Ceramide glucosyltransferase
|
|
| Galactosyl- |
- Lactose synthase
- B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
- Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1)
|
|
| Glucuronosyl- |
- UGT1A1
- UGT1A3
- UGT1A4
- UGT1A5
- UGT1A6
- UGT1A7
- UGT1A8
- UGT1A9
- UGT1A10
- UGT2A1
- UGT2A2
- UGT2A3
- UGT2B4
- UGT2B7
- UGT2B10
- UGT2B11
- UGT2B15
- UGT2B17
- UGT2B28
- Hyaluronan synthase: HAS1
- HAS2
- HAS3
|
|
| Fucosyl- |
- POFUT1
- POFUT2
- FUT1
- FUT2
- FUT3
- FUT4
- FUT5
- FUT6
- FUT7
- FUT8
- FUT9
- FUT10
- FUT11
|
|
| Mannosyl- |
- Dolichyl-phosphate-mannose-protein mannosyltransferase
- DPM1
- DPM3
- ALG1
- ALG2
- ALG3
- ALG6
- ALG8
- ALG9
- ALG12
|
|
|
2.4.2: Pentosyl-
transferases |
| Ribose |
| ADP-ribosyltransferase |
- NAD+:diphthamide ADP-ribosyltransferase
- NAD(P)+:arginine ADP-ribosyltransferase
- Pertussis toxin
- Cholera toxin
- Poly ADP ribose polymerase
|
|
| Phosphoribosyltransferase |
- Adenine phosphoribosyltransferase
- Hypoxanthine-guanine phosphoribosyltransferase
- Uracil phosphoribosyltransferase
- Amidophosphoribosyltransferase
|
|
| Other |
- Purine nucleoside phosphorylase: Thymidine phosphorylase
|
|
|
| Other |
- Xylosyltransferase
- Arabinosyltransferase
- Indolylacetylinositol arabinosyltransferase
|
|
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2.4.99: Sialyl
transferases |
- Beta-galactoside alpha-2,6-sialyltransferase
- Monosialoganglioside sialyltransferase
- ST8SIA4
|
|
Enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
UpToDate Contents
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- 1. ギラン・バレー症候群：発症機序guillain barre syndrome pathogenesis [show details]
…specific gangliosides, including GM1, GD1a, GalNac-GD1a, and GD1b, which are strongly associated with AMAN or AMSAN . Similarly, C. jejuni infection can generate antibodies to GQ1b ganglioside, a component …
- 2. カンピロバクター感染症の臨床症状、診断、および治療clinical manifestations diagnosis and treatment of campylobacter infection [show details]
…response to epitopes expressed by the infecting Campylobacter strain that are cross-reactive to GM1 ganglioside (present in high concentrations in peripheral nerve myelin) . Many Campylobacter strains isolated …
- 3. ワルデンストレームマクログロブリン血症の疫学、発症機序、臨床症状、診断epidemiology pathogenesis clinical manifestations and diagnosis of waldenstrom macroglobulinemia [show details]
…pathogenetic significance have also been described, including those directed against GM1 ganglioside and asialo-GM1 ganglioside . Other neurologic manifestations can occur but are less common. These include cranial…
- 4. 異種移植および腎臓xenotransplantation and the kidney [show details]
…expresses hCD46, hCD55, and hCD59 . Eradicating Gal(alpha)1-3Gal by knocking out (alpha)1,3 galactosyltransferase, the enzyme that catalyzes synthesis of that sugar, in cloned pigs . The transplantation of…
- 5. 免疫誘導性神経障害immune mediated neuropathies [show details]
…pathogenetic significance have also been described, including those directed against GM1 ganglioside and asialo-GM1 ganglioside. Among patients with Waldenstrom macroglobulinemia and peripheral neuropathy, sural …
English Journal
- A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.
- Meech R1, Mubarokah N2, Shivasami A2, Rogers A2, Nair PC2, Hu DG2, McKinnon RA2, Mackenzie PI2.
- Molecular pharmacology.Mol Pharmacol.2015;87(3):442-50. doi: 10.1124/mol.114.093823. Epub 2014 Dec 17.
- The human UDP glycosyltransferase (UGT) superfamily comprises four families of enzymes that catalyze the addition of sugar residues to small lipophilic chemicals. The UGT1 and UGT2 enzymes use UDP-glucuronic acid, and UGT3 enzymes use UDP-N-acetylglucosamine, UDP-glucose, and UDP-xylose to conjugate
- PMID 25519837
- Gene expression levels of β4-galactosyltransferase 5 correlate with the tumorigenic potentials of B16-F10 mouse melanoma cells.
- Shirane K1, Kuji R, Tareyanagi C, Sato T, Kobayashi Y, Furukawa S, Murata T, Kubota S, Ishikawa Y, Segawa K, Furukawa K.
- Glycobiology.Glycobiology.2014 Jun;24(6):532-41. doi: 10.1093/glycob/cwu021. Epub 2014 Mar 20.
- Our previous studies showed that mouse β4-galactosyltransferase 5 (β4GalT5) is a lactosylceramide (Lac-Cer) synthase, and that its gene expression increases by 2- to 3-fold upon malignant transformation of cells. In the present study, we examined whether or not the tumorigenic and metastatic poten
- PMID 24653215
- Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice.
- Kanbe H1, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Wang L, Fang ZZ, Hara A, Gonzalez FJ, Aoyama T.
- Archives of toxicology.Arch Toxicol.2014 Feb;88(2):367-79. doi: 10.1007/s00204-013-1132-3. Epub 2013 Sep 25.
- Epidemiological studies demonstrate a possible relationship between chronic ethanol drinking and thrombotic diseases, such as myocardial infarction and stroke. However, the precise mechanism for this association remains unclear. Sulfatides are endogenous glycosphingolipids composed of ceramide, gala
- PMID 24065054
★リンクテーブル★
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- 英
- ganglioside galactosyltransferase
- 関
- ガングリオシドガラクトシルトランスフェラーゼ
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- 英
- ganglioside galactosyltransferase
- 関
- ガングリオシドガラクトシル転移酵素
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ガラクトース転移酵素、ガラクトシルトランスフェラーゼ、ガラクトシル基転移酵素