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English Journal

New findings in the pathogenesis of leprosy and implications for the management of leprosy.

Polycarpou A, Walker SL, Lockwood DN.SourceaDepartment of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine bThe Hospital of Tropical Diseases, London, UK.
Current opinion in infectious diseases.Curr Opin Infect Dis.2013 Oct;26(5):413-9. doi: 10.1097/QCO.0b013e3283638b04.
PURPOSE OF REVIEW: This review focuses on recent work in leprosy pathogenesis. New research of both innate and adaptive immune responses to Mycobacterium leprae is described. The proposition that Mycobacterium lepromatosis is a new species causing leprosy is discussed.RECENT FINDINGS: Modulation of
PMID 23982232

Secreted galectin-3 as a possible biomarker for the immunomodulatory potential of human umbilical cord mesenchymal stromal cells.

Liu GY, Xu Y, Li Y, Wang LH, Liu YJ, Zhu D.SourceKey Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China; Alliancells Institute of Stem Cells and Translational Regenerative Medicine, Tianjin, China.
Cytotherapy.Cytotherapy.2013 Oct;15(10):1208-17. doi: 10.1016/j.jcyt.2013.05.011. Epub 2013 Jul 11.
BACKGROUND AIMS: Human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) possess broad and potent immunomodulatory activities and have shown great potential in anti-inflammatory therapies. However, a biomarker that can be used to assess quickly and efficiently the immunomodulatory function
PMID 23850421

C-Reactive Protein (CRP) Is Essential for Efficient Systemic Transduction of Recombinant Adeno-Associated Virus Vector 1 (rAAV-1) and rAAV-6 in Mice.

Denard J, Marolleau B, Jenny C, Rao TN, Fehling HJ, Voit T, Svinartchouk F.SourceGenethon, Evry, France.
Journal of virology.J Virol.2013 Oct;87(19):10784-91. doi: 10.1128/JVI.01813-13. Epub 2013 Jul 31.
The clinical relevance of gene therapy using the recombinant adeno-associated virus (rAAV) vectors often requires widespread distribution of the vector, and in this case, systemic delivery is the optimal route of administration. Humoral blood factors, such as antibodies or complement, are the first
PMID 23903832