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English Journal

Comparative lectinology: Delineating glycan-specificity profiles of the chicken galectins using neoglycoconjugates in a cell assay.

Rapoport EM1, Matveeva VK1, Kaltner H2, André S2, Vokhmyanina OA1, Pazynina GV1, Severov VV1, Ryzhov IM1, Korchagina EY1, Belyanchikov IM1, Gabius HJ2, Bovin NV3.
Glycobiology.Glycobiology.2015 Jul;25(7):726-34. doi: 10.1093/glycob/cwv012. Epub 2015 Feb 13.
A major aspect of carbohydrate-dependent galectin functionality is their cross-linking capacity. Using a cell surface as biorelevant platform for galectin binding and a panel of 40 glycans as sensor part of a fluorescent polyacrylamide neoglycopolymer for profiling galectin reactivity, properties of
PMID 25681326

Galectin 2 (gal-2) expression is downregulated on protein and mRNA level in placentas of preeclamptic (PE) patients.

Hutter S1, Martin N2, von Schönfeldt V3, Messner J1, Kuhn C1, Hofmann S1, Andergassen U1, Knabl J4, Jeschke U5.
Placenta.Placenta.2015 Apr;36(4):438-45. doi: 10.1016/j.placenta.2015.01.198. Epub 2015 Feb 7.
INTRODUCTION: Galectin 2 (gal-2) belongs to the proto type group and consists of two homologous carbohydrate recognition domains (CRDs) resulting in multiple sugar binding sites. The expression of gal-2 has been shown to be involved in processes of angiogenesis and inflammation but was not analyzed
PMID 25707742

S-nitrosylation of mouse galectin-2 prevents oxidative inactivation by hydrogen peroxide.

Tamura M1, Saito M1, Yamamoto K1, Takeuchi T1, Ohtake K2, Tateno H3, Hirabayashi J3, Kobayashi J2, Arata Y4.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Feb 20;457(4):712-7. doi: 10.1016/j.bbrc.2015.01.055. Epub 2015 Jan 22.
Galectins are a group of animal lectins characterized by their specificity for β-galactosides. Galectin-2 (Gal-2) is predominantly expressed in the gastrointestinal tract. A proteomic analysis identified Gal-2 as a protein that was S-nitrosylated when mouse gastric mucosal lysates were reacted with
PMID 25619132

Engineering of a 3'-sulpho-Galβ1-4GlcNAc-specific probe by a single amino acid substitution of a fungal galectin

Prognostic Value of Plasma Galectin-3 Levels in Patients With Coronary Heart Disease and Chronic Heart Failure

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International Heart Journal 56(3), 314-318, 2015
… In this study, we evaluated the prognostic value of plasma galectin-3 levels in patients with coronary heart disease (CHD) and chronic heart failure (HF) and selected 261 CHD patients who were consecutively admitted to our hospital. … Galectin-3 and B-type natriuretic peptide (BNP) levels were determined and the primary endpoint was the composite of all-cause mortality and rehospitalization with 12-month follow-up. …
NAID 130005070018