WordNet
- agent that induces milk secretion
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/18 17:35:09」(JST)
[Wiki en表示]
Goat's rue (
Galega officinalis) is one plant that is thought to promote lactation
|
Look up galactagogue in Wiktionary, the free dictionary. |
A galactagogue, or galactogogue, (from Greek: γάλα [γαλακτ-], milk, + ἀγωγός, leading) is a substance that promotes lactation in humans and other animals.[1][2] It may be synthetic, plant-derived, or endogenous.
Contents
- 1 Pharmaceutical
- 2 Herbal
- 3 References
- 4 Further reading
- 5 See also
- 6 External links
Pharmaceutical
Synthetic galactagogues such as domperidone and metoclopramide interact with the dopamine system in such a way to increase the production of prolactin.[3] There is some evidence to suggest that mothers who are unable to meet their infants' breastfeeding needs may benefit from galactogogues.[4][5] Galactagogues may be considered when non-pharmacologic interventions are found to be insufficient.[6][7] For example, domperidone may be an option for mothers of preterm babies who at over 14 days from delivery and after full lactation support still have difficulty expressing breast milk in sufficient quantity for their child's needs.[8]
Domperidone (like metoclopramide, a dopamine-receptor antagonist) is not approved for enhanced lactation in the USA.[9][10] By contrast, Australian guidelines consider domperidone to be the preferred galactagogue when non-pharmacological approaches have proved insufficient.[6] Unlike metoclopramide, domperidone does not cross the blood-brain barrier and does not tend to have adverse effects such as drowsiness or depression.[6]
Other drugs which may increase lactation include:
- some types of antipsychotics such as risperidone, chlorpromazine and sulpiride[11]
- some hormones such as oxytocin, growth hormone, thyrotrophin releasing hormone and medroxyprogesterone acetate[11]
Herbal
Herbals and foods used as galactogogues have little or no scientific evidence of efficacy and the identity and purity of herbals are concerns because of inadequate testing requirements.[12][13] The herbals most commonly cited as galactagogues are:[13]
- shatavari (Asparagus racemosus)[13]
- fenugreek (Trigonella foenumgraecum)[13][14]
- torbangun (Coleus amboinicus), which has been used by the Bataknese people of Indonesia as a galactogogue for hundreds of years.[13][15]
- fennel (Foeniculum vulgare)[13]
- milk thistle (Silybum marianum)[13]
- chasteberry (Vitex agnus castus)[13]
- goat’s rue (Galega officinalis)[13]
Other herbals that have been claimed to be galactagogues include:
- blessed thistle[16][17]
- alfalfa[17]
- anise[17]
- nettle[17]
- oatmeal[17]
- vervain[17]
- red raspberry leaf[17]
- marshmallow (althaea) root[17]
Herbal galactogogues are divided into those believed to also have a sedating action on the nursing infant due to their volatile constituents, which can be carried through the breast milk itself, and those seen as promoting milk production without directly affecting the content. This often seems to be linked to anethol content.[18]
References
- ^ Gabay, M. P. (2002). "Galactogogues: Medications that induce lactation". Journal of human lactation : official journal of International Lactation Consultant Association 18 (3): 274–279. PMID 12192964. edit
- ^ Merriam-Webster: galactogogue
- ^ Forinash AB, Yancey AM, Barnes KN, Myles TD (2012). "The use of galactogogues in the breastfeeding mother". Ann Pharmacother 46 (10): 1392–404. doi:10.1345/aph.1R167. PMID 23012383.
- ^ McInnes RJ, Chambers J (2008). "Infants admitted to neonatal units—interventions to improve breastfeeding outcomes: a systematic review 1990-2007". Matern Child Nutr 4 (4): 235–63. doi:10.1111/j.1740-8709.2008.00150.x. PMID 18811790.
- ^ Osadchy A, Moretti ME, Koren G (2012). "Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials". Obstet Gynecol Int 2012: 642893. doi:10.1155/2012/642893. PMC 3306907. PMID 22461793.
- ^ a b c Amir LH, Pirotta MV, Raval M (2011). "Breastfeeding—evidence based guidelines for the use of medicines". Aust Fam Physician 40 (9): 684–90. PMID 21894275.
- ^ Forinash AB, Yancey AM, Barnes KN, Myles TD (October 2012). "The use of galactogogues in the breastfeeding mother". Ann Pharmacother 46 (10): 1392–404. doi:10.1345/aph.1R167. PMID 23012383.
- ^ Donovan TJ, Buchanan K (2012). "Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants". Cochrane Database Syst Rev 3: CD005544. doi:10.1002/14651858.CD005544.pub2. PMID 22419310.
- ^ Da Silva, O. P.; Knoppert, D. C. (2004). "Domperidone for lactating women". Canadian Medical Association Journal 171 (7): 725–726. doi:10.1503/cmaj.1041054. PMC 517853. PMID 15451832. edit
- ^ The Academy Of Breastfeeding Medici (2011). "ABM Clinical Protocol #9: Use of Galactogogues in Initiating or Augmenting the Rate of Maternal Milk Secretion (First Revision January 2011)". Breastfeeding Medicine 6 (1): 41–49. doi:10.1089/bfm.2011.9998. PMID 21332371. edit
- ^ a b Zuppa, Antonio; Paola Sindico, Claudia Orchi, Chiara Carducci, Valentina Cardiello, Costantino Romagnoli, Piero Catenazzi. (2010). "Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production". Journal of Pharmacy & Pharmaceutical Sciences 13 (2): 162–174.
- ^ Anderson, P. O. (31 December 2012). "The Galactogogue Bandwagon". Journal of Human Lactation 29 (1): 7–10. doi:10.1177/0890334412469300. PMID 23277457.
- ^ a b c d e f g h i Mortel M, Mehta SD (May 2013). "Systematic review of the efficacy of herbal galactogogues". J Hum Lact 29 (2): 154–62. doi:10.1177/0890334413477243. PMID 23468043.
- ^ Chantry, Caroline J.; Howard, Cynthia R; Montgomery, Anne; Wight, Nancy (2004). "Use of galactogogues in initiating or augmenting maternal milk supply" (PDF). ABM protocols, Protocol#9. The Academy Of Breastfeeding Medicine. Archived from the original on 28 June 2007.
Supported in part by a grant from the Maternal and Child Health Bureau, Department of Health and Human Services.
- ^ Damanik R, Wahlqvist ML, Wattanapenpaiboon N (2006). "Lactagogue effects of Torbangun, a Bataknese traditional cuisine". Asia Pac J Clin Nutr 15 (2): 267–74. PMID 16672214.
- ^ http://canadianbreastfeedingfoundation.org/induced/herbs.shtml
- ^ a b c d e f g h Nice, F. J. (19 May 2011). "Common Herbs and Foods Used as Galactogogues". ICAN: Infant, Child, & Adolescent Nutrition 3 (3): 129–132. doi:10.1177/1941406411406118.
- ^ McIntyre, Anne (1992). The herbal for mother and child. Shaftesbury: Element. ISBN 1-85230-244-5.
Further reading
- Diana West and L. Marasco, The Breastfeeding Mother's Guide to Making More Milk. New York: McGraw-Hill, 2008.
See also
External links
- New Zealand government website on Domperidone (Motilium) as a Galactogogue
|
Look up galactogogue in Wiktionary, the free dictionary. |
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 授乳および離乳の一般的問題 common problems of breastfeeding and weaning
- 2. 早産児のための搾乳 breast milk expression for the preterm infant
English Journal
- The Use, Perceived Effectiveness and Safety of Herbal Galactagogues During Breastfeeding: A Qualitative Study.
- Sim TF1, Hattingh HL2, Sherriff J3, Tee LB4.
- International journal of environmental research and public health.Int J Environ Res Public Health.2015 Sep 7;12(9):11050-71. doi: 10.3390/ijerph120911050.
- The World Health Organization recommends breastfeeding as the normal infant feeding method and that infants being breastfed should be regarded as the control group or norm reference in all instances. There are many factors which could contribute to a new mother ceasing breastfeeding early, with the
- PMID 26371019
- Evaluation of a lactogenic activity of an aqueous extract of Cyperus rotundus Linn.
- Badgujar SB1, Bandivdekar AH2.
- Journal of ethnopharmacology.J Ethnopharmacol.2015 Apr 2;163:39-42. doi: 10.1016/j.jep.2015.01.019. Epub 2015 Jan 24.
- ETHNOPHARMACOLOGICAL RELEVANCE: In Ayurveda, the rhizome of Cyperus rotundus Linn has been reported for wide spectrum of biological activities including lactational therapy for increasing milk quantity. However, not a single report is available on validation of its herbal galactagogue potentiality i
- PMID 25625349
- Effects of maternal exposure to the galactagogue Sulpiride on reproductive parameters in female rats.
- de Azevedo Camin N1, Vieira ML1, Montagnini BG1, Kiss AC2, Gerardin DC3.
- Physiology & behavior.Physiol Behav.2015 Mar 1;140:247-53. doi: 10.1016/j.physbeh.2014.12.047. Epub 2014 Dec 30.
- The antipsychotic Sulpiride has been documented as an effective galactagogue that acts blocking dopamine receptors, increasing prolactin concentrations. However, this drug passes through the milk exposing neonates during postnatal development, which may result in functional and morphological alterat
- PMID 25554483
Japanese Journal
- Angelica keiskei Ameliorates Scopolamine-Induced Memory Impairments in Mice
- Oh Sa Rang,Kim Su-Jin,Kim Dong Hyun,Ryu Jong Hoon,Ahn Eun-Mi,Jung Ji Wook
- Biological and Pharmaceutical Bulletin 36(1), 82-88, 2013
- … Angelica keiskei (AK) has traditionally been used as a diuretic, laxative, analeptic and galactagogue. …
- NAID 130001869765
Related Links
- A galactagogue is an herb that is used to help increase breastmilk production in nursing mothers. Below is a list of some of the more effective and popular ones and some important information about each:
- Galactagogues Quick Page Links What are galactagogues? When is a Galactagogue Necessary? Safe Galactagogue Herbs Include Galactagogue Foods A Lactation Cookie Recipe Galactogue Drugs A simulated pregnancy/birth ...
Related Pictures
★リンクテーブル★
[★]
- 英
- lactagogue, galactagogue