English Journal

Synthesis of (11)C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography.

Doi H1, Mawatari A1, Kanazawa M1, Nozaki S1, Nomura Y2, Kitayoshi T2, Akimoto K2, Suzuki M3, Ninomiya S2, Watanabe Y1.
The Journal of organic chemistry.J Org Chem.2015 Jun 19;80(12):6250-8. doi: 10.1021/acs.joc.5b00685. Epub 2015 Jun 1.
To enable in vivo analysis of the kinetics of vitamin B1 (thiamine) and its derivatives by positron emission tomography (PET), (11)C-labeled thiamine ([(11)C]-1) has been synthesized. This was carried out via a rapid, multistep synthesis consisting of Pd(0)-mediated C-[(11)C]methylation of a thiazol
PMID 25984933

Fung E1, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E.
Molecular pharmacology.Mol Pharmacol.2013 Mar;83(3):681-90. doi: 10.1124/mol.112.083428. Epub 2013 Jan 4.
Anemia of inflammation (AI) is common in patients with infection, autoimmune diseases, cancer, and chronic kidney disease. Unless the underlying condition can be reversed, treatment options are limited to erythropoiesis-stimulating agents with or without intravenous iron therapy, modalities that are
PMID 23292796

The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice.

Hills JI1, Golub MS, Bettendorff L, Keen CL.
Neurotoxicology and teratology.Neurotoxicol Teratol.2012 Mar;34(2):242-52. doi: 10.1016/j.ntt.2011.07.006. Epub 2011 Jul 24.
Due to genetic defects or illness some individuals require higher amounts of thiamin than are typically provided by the diet. Lipid-soluble thiamin precursors can achieve high blood levels of thiamin and result in increased concentrations in the central nervous system. High intakes of thiamin have b
PMID 21816221