WordNet

unconstrained or not chemically bound in a molecule or not fixed and capable of relatively unrestricted motion; "free expansion"; "free oxygen"; "a free electron"
people who are free; "the home of the free and the brave" (同)free people
free from obligations or duties (同)discharge
free or remove obstruction from; "free a path across the cluttered floor" (同)disengage
grant freedom to; free from confinement (同)liberate, release, unloose, unloosen, loose
not literal; "a loose interpretation of what she had been told"; "a free translation of the poem" (同)loose, liberal
make (information) available for publication; "release the list with the names of the prisoners" (同)release
able to act at will; not hampered; not under compulsion or restraint; "free enterprise"; "a free port"; "a free country"; "I have an hour free"; "free will"; "free of racism"; "feel free to stay as long as you wish"; "a free choice"
not held in servitude; "after the Civil War he was a free man"
not occupied or in use; "a free locker"; "a free lane"

PrepTutorEJDIC

(束縛された状態になく)『自由な』,自由の身の / (国家・国民などが)『独立している』 / (思想・行為などが)強制されない,自発的な / (動作が)拘束されない,無理のない / 《補語にのみ用いて》(苦痛・制約などを)『免れている』,(誤り・偏見などの)ない《+『from』(『of』)+『名』》 / 《補語にのみ用いて》《『be free to』do》『自由に』…『できる』 / (仕事から)解放された,暇になった;(部屋などが)使用されていない,空いた / 『無料の』;無税の / 出し惜しみしない / 遠慮のない,慎みがない / (道路などが)障害のない,自由に通れる / 固定していない,離れた / 無料で / 自由に,妨げられずに(freely) / (…から)〈人・国など〉‘を'『自由にする』,解放する《+『名』+『from』+『名』》 / (困難などから)〈人〉‘を'救う《+『名』+『form』+『名』》 / (障害などを)〈人・物〉‘から'取り除く《+『名』+『of』(『from』)+『名』》 / (物を)…‘から'片付ける,外す《+『名』+『of』+『名』》

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Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.

Tripathi S1, Srivastava G1, Sharma A2.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Aug 5;476(4):273-9. doi: 10.1016/j.bbrc.2016.05.112. Epub 2016 May 24.
Drug resistance poses a threatening challenge for mankind, as the development of resistance to already well-established drugs causes serious therapeutic problems. Resistance to paclitaxel (Ptxl), a complex diterpenoid working as microtubule stabilizer, is one such issue in cancer treatment. Microtub
PMID 27233604

Nepali K1, Ojha R1, Lee HY1, Liou JP1.
Expert opinion on investigational drugs.Expert Opin Investig Drugs.2016 Aug;25(8):917-36. doi: 10.1080/13543784.2016.1189901. Epub 2016 May 30.
INTRODUCTION: Microtubules represent one of the most logical and strategic molecular targets amongst the current targets for chemotherapy, alongside DNA. In the past decade, tubulin inhibitors as cancer therapeutics have been an area of focus due to the improved understanding and biological relevanc
PMID 27186892

Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays.

Belair DG1, Schwartz MP1, Knudsen T2, Murphy WL3.
Acta biomaterialia.Acta Biomater.2016 Jul 15;39:12-24. doi: 10.1016/j.actbio.2016.05.020. Epub 2016 May 13.
Activation of vascular endothelial cells (ECs) by growth factors initiates a cascade of events during angiogenesis in vivo consisting of EC tip cell selection, sprout formation, EC stalk cell proliferation, and ultimately vascular stabilization by support cells. Although EC functional assays can rec
PMID 27181878

桜井隆史
宇宙生物科学 = Biological sciences in space 22(4), 158-166, 2008-12-01
… 細胞は細胞骨格の成分であるtubulinと微小管により周囲の機械的環境に反応する。 … 微小管はダイナミックインスタビリティという性質を持ち、その構成成分のtubulin量は微小管と二量体とのバランスにより制御されている。 …
NAID 10025115118

Differentiation of Serum-Free Mouse Embryo Cells into an Astrocytic Lineage is Associated with the Asymmetric Production of Early Neural, Neuronal and Glial Markers(Molecular and Cell Biology)

, , [他],
Biological & pharmaceutical bulletin 31(5), 1008-1012, 2008-05-01
… Serum-free mouse embryo (SFME) cells, the astrocyte progenitor cells in the central nervous system (CNS), were exposed to 10 ng/ml leukemia inhibitory factor (LIF) and 10 ng/ml bone morphogenic protein 2 (BMP2) to induce differentiation, and expression of cell-type specific markers. … Nestin, a marker of early neural lineage, βIII-tubulin, a marker of neuronal lineage, oligodendrocyte marker O4 (O4), a marker of oligodendrocytic lineage and glial fibrillary acidic protein (GFAP), a marker of astrocytic lineage, were analyzed. …
NAID 110006663970

亀山泰永,北村圭司,八代耕児,神谷真子,藤田厚
岐阜歯科学会雑誌 34(3), 99-104, 2008-02-20
… To investigate the significance of cytoskeletal proteins in the exocytotic in vitro interaction system, we observed theeffects of two types of inhibitors, colchicine and cytochalasin D, which depolymerize the microtuble structure consistingof tubulin and microfilament consisting of actins, respectively. … On the other hands, cytochalasin D, an inhibitor of actin polymerization, in the cell-free reconstitution systemdid not affect apical plasma membrane-evoked amylase release. …
NAID 110007405489

関: ad lib、ad libitum、deprive、disengage、free form、free of charge、freedom、freely、liberate、liberation、obviate、omit、release、remove、strip、withdraw