WordNet

a phagocyte that circulates in the blood
unconstrained or not chemically bound in a molecule or not fixed and capable of relatively unrestricted motion; "free expansion"; "free oxygen"; "a free electron"
people who are free; "the home of the free and the brave" (同)free people
free from obligations or duties (同)discharge
free or remove obstruction from; "free a path across the cluttered floor" (同)disengage
grant freedom to; free from confinement (同)liberate, release, unloose, unloosen, loose
not literal; "a loose interpretation of what she had been told"; "a free translation of the poem" (同)loose, liberal
make (information) available for publication; "release the list with the names of the prisoners" (同)release
able to act at will; not hampered; not under compulsion or restraint; "free enterprise"; "a free port"; "a free country"; "I have an hour free"; "free will"; "free of racism"; "feel free to stay as long as you wish"; "a free choice"
not held in servitude; "after the Civil War he was a free man"
not occupied or in use; "a free locker"; "a free lane"
a cell that engulfs and digests debris and invading microorganisms (同)scavenger cell

PrepTutorEJDIC

(束縛された状態になく)『自由な』,自由の身の / (国家・国民などが)『独立している』 / (思想・行為などが)強制されない,自発的な / (動作が)拘束されない,無理のない / 《補語にのみ用いて》(苦痛・制約などを)『免れている』,(誤り・偏見などの)ない《+『from』(『of』)+『名』》 / 《補語にのみ用いて》《『be free to』do》『自由に』…『できる』 / (仕事から)解放された,暇になった;(部屋などが)使用されていない,空いた / 『無料の』;無税の / 出し惜しみしない / 遠慮のない,慎みがない / (道路などが)障害のない,自由に通れる / 固定していない,離れた / 無料で / 自由に,妨げられずに(freely) / (…から)〈人・国など〉‘を'『自由にする』,解放する《+『名』+『from』+『名』》 / (困難などから)〈人〉‘を'救う《+『名』+『form』+『名』》 / (障害などを)〈人・物〉‘から'取り除く《+『名』+『of』(『from』)+『名』》 / (物を)…‘から'片付ける,外す《+『名』+『of』+『名』》
食細胞(異物・バクテリアなどの細胞を処理する血球)

UpToDate Contents

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1. 胎児の染色体によくみられる異数性を調べるために細胞フリーDNAを用いる異数性スクリーニング prenatal screening for common aneuploidies using cell free dna
2. 多発性骨髄腫の治療に対する奏効性評価 evaluating response to treatment of multiple myeloma
3. 頭頸部癌患者における下顎および口蓋再建 mandibular and palatal reconstruction in patients with head and neck cancer
4. 原発性免疫不全の胃腸症状 gastrointestinal manifestations in primary immunodeficiency
5. 多発性骨髄腫の臨床的特徴、検査所見、および診断 clinical features laboratory manifestations and diagnosis of multiple myeloma

English Journal

Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease.

Streeter J, Thiel W, Brieger K, Miller FJ Jr.SourceDepartments of Anatomy and Cell Biology, Free Radical and Radiation Biology, and Internal Medicine, University of Iowa, Iowa City, IA, USA.
Cardiovascular therapeutics.Cardiovasc Ther.2013 Jun;31(3):125-37. doi: 10.1111/j.1755-5922.2011.00310.x. Epub 2012 Jan 26.
Over 40 years ago, NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 2 (Nox2) was discovered in phagocytes and found to be essential in innate immunity. More than 20 years passed before additional Nox isoforms were discovered; and since then, studies have revealed that several of these iso
PMID 22280098

High mortality of juvenile gilthead sea bream (Sparus aurata) from photobacteriosis is associated with alternative macrophage activation and anti-inflammatory response: Results of gene expression profiling of early responses in the head kidney.

Pellizzari C, Krasnov A, Afanasyev S, Vitulo N, Franch R, Pegolo S, Patarnello T, Bargelloni L.SourceDepartment of Comparative Biomedicine and Food Science, University of Padova, viale dell'Università 16, 35020 Legnaro, Italy.
Fish & shellfish immunology.Fish Shellfish Immunol.2013 May;34(5):1269-78. doi: 10.1016/j.fsi.2013.02.007. Epub 2013 Feb 24.
The halophilic bacterium Photobacterium damselae subsp. piscicida (Phdp) represents a substantial health problem for several fish species in aquaculture. Bacteria that reside free and inside phagocytes cause acute and chronic forms of photobacteriosis. Infections of juveniles rapidly kill up to 90-1
PMID 23485716

Mitochondrial (dys)function and regulation of macrophage cholesterol efflux.

Allen AM, Taylor JM, Graham A.SourceDepartment of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, UK.
Clinical science (London, England : 1979).Clin Sci (Lond).2013 Apr;124(8):509-15. doi: 10.1042/CS20120358.
Cholesterol trafficking from the outer to the cholesterol-poor inner mitochondrial membrane requires energized, polarized and actively respiring mitochondria, mediated by a highly regulated multimeric (140-200 kDa) protein complex comprising StAR (steroidogenic acute regulatory protein), mitochondri
PMID 23298226

Japanese Journal

Evaluation of radical scavenging properties of shikonin

Yoshida Lucia S.,Kohri Shunji,Tsunawaki Shohko,Kakegawa Tomohito,Taniguchi Taizo,Takano-Ohmuro Hiromi,Fujii Hirotada
Journal of Clinical Biochemistry and Nutrition 55(2), 90-96, 2014
… Concerning another source of O2•−, the phagocyte NADPH oxidase (Nox2), shikonin inhibited the Nox2 activity by impairing catalysis when added before enzyme activation (IC50: 1.1 µM; …
NAID 130004678431

食細胞の機能と低酸素環境

大野秀樹,白土健,櫻井拓也 [他]
臨床免疫・アレルギー科 55(2), 239-246, 2011-02
NAID 40018745187

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi FujiiPhysiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme

Katsuyama Masato,Matsuno Kuniharu,Yabe-Nishimura Chihiro
Journal of Clinical Biochemistry and Nutrition 50(1), 9-22, 2011
… In the last decade, several non-phagocyte-type NADPH oxidases have been identified. …
NAID 130004466676

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