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English Journal

Neurological improvement following intravenous high-dose folinic acid for cerebral folate transporter deficiency caused by FOLR-1 mutation.

Delmelle F1, Thöny B2, Clapuyt P1, Blau N3, Nassogne MC4.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.Eur J Paediatr Neurol.2016 Jun 13. pii: S1090-3798(16)30078-2. doi: 10.1016/j.ejpn.2016.05.021. [Epub ahead of print]
BACKGROUND: Cerebral folate transporter deficiency caused by FOLR-1 mutations has been described in 2009. This condition is characterized by a 5MTHF level <5 nmol/l in the CSF, along with regression of acquisition in the second year of life, ataxia, and refractory myoclonic epilepsy. Oral or int
PMID 27328863

Ruiz-Rico M1, Daubenschüz H2, Pérez-Esteve É2, Marcos MD3, Amorós P4, Martínez-Máñez R3, Barat JM2.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2016 May 25. pii: S0939-6411(16)30181-3. doi: 10.1016/j.ejpb.2016.05.016. [Epub ahead of print]
Mesoporous silica particles (MSPs) are considered suitable supports to design gated materials for the encapsulation of bioactive molecules. Folates are essential micronutrients which are sensitive to external agents that provoke nutritional deficiencies. Folates encapsulation in MSPs to prevent degr
PMID 27235728

Holden HM1, Thoden JB2, Gilbert M3.
Current opinion in structural biology.Curr Opin Struct Biol.2016 May 19;41:1-9. doi: 10.1016/j.sbi.2016.04.003. [Epub ahead of print]
The N-formyltransferases, also known as transformylases, play key roles in de novo purine biosynthesis where they catalyze the transfer of formyl groups to primary amine acceptors. These enzymes require N10-formyltetrahydrofolate for activity. Due to their biological importance they have been extens
PMID 27209114