関: fMLP、N-formyl-methionyl-leucyl-phenylalanine、N-formylmethionine leucyl-phenylalanine

English Journal

Polesskaya O1, Wong C2, Lebron L3, Chamberlain JM3, Gelbard HA4, Goodfellow V5, Kim M6, Daiss JL7, Dewhurst S8.
Molecular immunology.Mol Immunol.2014 Apr;58(2):214-22. doi: 10.1016/j.molimm.2013.11.016. Epub 2014 Jan 3.
INTRODUCTION: Mixed lineage kinase 3 (MLK3) is part of the intracellular regulatory system that connects extracellular cytokine or mitogen signals received through G-protein coupled receptors to changes in gene expression. MLK3 activation stimulates motility of epithelial cells and epithelial-derive
PMID 24389043

IL-5 induces suspended eosinophils to undergo unique global reorganization associated with priming.

Han ST1, Mosher DF.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2014 Mar;50(3):654-64. doi: 10.1165/rcmb.2013-0181OC.
The experiments described herein define a unique program of polarization of suspended human eosinophils stimulated with IL-5 family cytokines. We found that eosinophil granules and the nucleus move in opposite directions to form, respectively, a granular compartment and the nucleopod, a specialized
PMID 24156300

Shear-sensitive regulation of neutrophil flow behavior and its potential impact on microvascular blood flow dysregulation in hypercholesterolemia.

Zhang X1, Cheng R, Rowe D, Sethu P, Daugherty A, Yu G, Shin HY.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 Mar;34(3):587-93. doi: 10.1161/ATVBAHA.113.302868. Epub 2014 Jan 23.
OBJECTIVE: Shear stress-induced pseudopod retraction is an anti-inflammatory measure that minimizes neutrophil activity and is regulated by membrane cholesterol. We tested the hypothesis that a hypercholesterolemic impairment of shear mechanotransduction alters the neutrophil flow behavior leading t
PMID 24458712

Japanese Journal

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Journal of Clinical Biochemistry and Nutrition 13(1), 31-43, 1992
… On the contrary, it inhibited O2- formation by PMNs induced by N-formylmethionylleucylphenylalanine, concanavalin A plus cytocalasin B, or phorbol 12-myristate 13-acetate. …
NAID 130003670232

Inhibitory effect of antibiotic cerulenin on the respiratory burst in phagocytes. II. Inhibition by cerulenin of intracellular calcium mobilization in human neutrophils.:II. INHIBITION BY CERULENIN OF INTRACELLULAR CALCIUM MOBILIZATION IN HUMAN NEUTROPHILS

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The Journal of Antibiotics 42(7), 1178-1183, 1989
… Generation of superoxide anion (O2-) and mobilization of intracellular Ca2+ in human neutrophils upon exposure to stimuli such as N-formylmethionylleucylphenylalanine (fMLP) were inhibited by the antibiotic cerulenin, which inhibits fatty acid and cholesterol biosynthesis. …
NAID 130003409900

Inhibitory effect of antibiotic cerulenin on the respiratory burst in phagocytes. I. Effects of cerulenin on active oxygen-generation and lipid metabolism in phagocytes.:I. EFFECTS OF CERULENIN ON ACTIVE OXYGEN-GENERATION AND LIPID METABOLISM IN PHAGOCYTES

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The Journal of Antibiotics 42(7), 1171-1177, 1989
… The antibiotic also inhibited the CL response of human neutrophils upon exposure to various stimuli such as chemotactic pep tide N-formylmethionylleucylphenylalanine (fMLP), calcium ionophore A23187 and Staphylococcal delta toxin. …
NAID 130003409894