formoterol

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/03/02 11:11:20」(JST)

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英文文献

  • Formoterol, a Long-Acting β2 Adrenergic Agonist, Improves Cognitive Function and Promotes Dendritic Complexity in a Mouse Model of Down Syndrome.
  • Dang V1, Medina B2, Das D2, Moghadam S2, Martin KJ2, Lin B2, Naik P2, Patel D2, Nosheny R3, Wesson Ashford J1, Salehi A4.Author information 1Department of Psychiatry and Behavioral Sciences (VD, JWA, AS); Veterans Administration Palo Alto Health Care System (VD, BM, DD, SM, KJM, BL, PN, DP, JWA, AS), Palo Alto, California.2Veterans Administration Palo Alto Health Care System (VD, BM, DD, SM, KJM, BL, PN, DP, JWA, AS), Palo Alto, California.3Department of Molecular and Cellular Physiology (RN), Stanford University School of Medicine, Stanford.4Department of Psychiatry and Behavioral Sciences (VD, JWA, AS); Veterans Administration Palo Alto Health Care System (VD, BM, DD, SM, KJM, BL, PN, DP, JWA, AS), Palo Alto, California. Electronic address: asalehi@stanford.edu.AbstractBACKGROUND: Down syndrome is associated with significant failure in cognitive function. Our previous investigation revealed age-dependent degeneration of locus coeruleus, a major player in contextual learning, in the Ts65Dn mouse model of Down syndrome. We studied whether drugs already available for use in humans can be used to improve cognitive function in these mice.
  • Biological psychiatry.Biol Psychiatry.2014 Feb 1;75(3):179-88. doi: 10.1016/j.biopsych.2013.05.024. Epub 2013 Jul 1.
  • BACKGROUND: Down syndrome is associated with significant failure in cognitive function. Our previous investigation revealed age-dependent degeneration of locus coeruleus, a major player in contextual learning, in the Ts65Dn mouse model of Down syndrome. We studied whether drugs already available for
  • PMID 23827853
  • Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors.
  • Huang L1, Shan W2, Zhou Q1, Xie J3, Lai K3, Li X4.Author information 1Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.2Jiangsu Hansoh Pharmaceutical Research Institute Co., Ltd, Lianyungang 222000, China.3State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.4Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: lixs@mail.sysu.edu.cn.AbstractA novel series of formoterol-phthalazinone hybrids were synthesised and evaluated as dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Most of the hybrids displayed high β2-adrenoceptor agonist and moderate PDE4 inhibitory activities. The most potent compound, (R,R)-11c, exhibited agonist (EC50=1.05nM, pEC50=9.0) and potent PDE4B2 inhibitory activities (IC50=0.092μM).
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Jan 1;24(1):249-53. doi: 10.1016/j.bmcl.2013.11.028. Epub 2013 Nov 21.
  • A novel series of formoterol-phthalazinone hybrids were synthesised and evaluated as dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Most of the hybrids displayed high β2-adrenoceptor agonist and moderate PDE4 inhibitory activities. The most potent compound, (R,R)-11c, exhibited ag
  • PMID 24300734
  • Safety of formoterol in asthma clinical trials: an update.
  • Sears MR, Radner F.Author information St Joseph's Healthcare and McMaster University, Hamilton, ON, Canada.AbstractUse of long-acting β-agonists (LABAs) in asthma remains controversial, and large safety trials are in progress. We have previously reported safety outcomes with formoterol in 117 AstraZeneca asthma trials (78 339 patients, 92% using inhaled corticosteroids) completed by December 2006, and have now added 32 trials with formoterol (26 124 patients, 100% using inhaled corticosteroids) completed by December 2011. The primary dataset of 79 randomised controlled trials includes 94 684 patients, 67 380 of whom were exposed to formoterol, while the complete dataset comprises 149 trials and 104 463 patients. There were no new asthma-related deaths in the expanded primary dataset, with eight asthma-related deaths among formoterol-randomised patients and two among non-LABA-randomised patients (relative risk 1.13, 95% CI 0.23-10.9), and 15 versus nine cardiac-related deaths (relative risk 0.47, 95% CI 0.19-1.22). Nonfatal asthma-related serious adverse events were significantly reduced with formoterol (relative risk 0.63, 95% CI 0.53-0.75), as were discontinuations due to adverse events. Examining 40 trials with direct formoterol versus non-LABA comparisons, Mantel-Haenszel relative risk for asthma-related death was 2.75 (95% CI 0.52-14.4) and for serious adverse events 0.83 (95% CI 0.68-1.02). We conclude that this enlarged dataset indicates no increased risk of asthma-related deaths among patients exposed to formoterol compared with non-LABA treatments, although the wide confidence interval precludes certainty.
  • The European respiratory journal.Eur Respir J.2014 Jan;43(1):103-14. doi: 10.1183/09031936.00004713. Epub 2013 May 30.
  • Use of long-acting β-agonists (LABAs) in asthma remains controversial, and large safety trials are in progress. We have previously reported safety outcomes with formoterol in 117 AstraZeneca asthma trials (78 339 patients, 92% using inhaled corticosteroids) completed by December 2006, and have now
  • PMID 23722615

和文文献

  • 好酸球性炎症残存末梢気道病変を有する喘息患者に対するフルチカゾン/ホルモテロールエアゾールとフルチカゾン/サルメテロールディスカスとの治療効果の比較
  • 気管支喘息の維持療法におけるブデソニド/ホルモテロールフマル酸塩水和物吸入剤(シムビコート タービュヘイラー)の長期使用の安全性と有効性の検討 : 特定使用成績調査の報告
  • 気管支喘息におけるブデソニド/ホルモテロール配合剤とフルチカゾン/サルメテロール配合剤のアドヒアランスの検討

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Foradil Aerolizer (formoterol fumarate)Formoterol BayvitFormoterol Fumarate/ Budesonide Inhaler File:Formoterol skeletal.svg - Wikimedia fostair.jpgHome > Respiratory System > Formoterol


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