fomivirsen sodium

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fomivirsen

WordNet

1. a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

PrepTutorEJDIC

1. ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/28 23:05:24」(JST)

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Fomivirsen

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	AU: B2
Routes of administration	Intravitreal injection
Identifiers
CAS Registry Number	160369-77-7 Y
ATC code	S01AD08
KEGG	D02736 Y
ChEMBL	CHEMBL1201688 N
Chemical data
Formula	C204H263N63O114P20S20
Molecular mass	6682.4 g/mol
N (what is this?)  (verify)

Fomivirsen (brand name Vitravene) is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. It was licenced by the FDA for CMV in Aug 1998.

It is a synthetic 21 member oligonucleotide with phosphorothioate linkages (which are resistant to degradation by nucleases) and has the sequence:

• 5'-GCG TTT GCT CTT CTT CTT GCG-3'

Mechanism

It is an oligonucleotide that blocks translation of viral mRNA by binding to the complementary sequence of the mRNA transcribed from the template segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.

Administration

It is available as an intraocular injection in a concentration of 6.6 mg/mL.

See also

• retinitis

References

Further reading

• Grillone, LR; Lanz, R (2001). "Fomivirsen". Drugs Today (Barc) 37 (4): 245–255. PMID 12768225. 
• Geary R, Henry S, Grillone L (2002). "Fomivirsen: clinical pharmacology and potential drug interactions". Clin Pharmacokinet 41 (4): 255–60. doi:10.2165/00003088-200241040-00002. PMID 11978144. 
• Vitravene Study, Group (2002). "Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS". Am J Ophthalmol 133 (4): 475–83. doi:10.1016/S0002-9394(02)01326-0. PMID 11931781. 
• Roehr B (1998). "Fomivirsen approved for CMV retinitis". J Int Assoc Physicians AIDS Care 4 (10): 14–6. PMID 11365956. 

External links

• MedlinePlus DrugInfo uspdi-203675
• DDB 31313

• "Vitravene (Fomivirsen) Drug Information: Uses, Side Effects, Drug Interactions and Warning". RxList. 2004-12-08. Retrieved 2009-05-20. 

UpToDate Contents

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• 1. AIDS関連サイトメガロウイルス網膜炎の治療 treatment of aids related cytomegalovirus retinitis
• 2. AIDS関連サイトメガロウイルス網膜炎の病因、臨床症状、および診断 pathogenesis clinical manifestations and diagnosis of aids related cytomegalovirus retinitis
• 3. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
• 4. 急性腎障害（急性腎不全）におけるナトリウム（FENa）、尿素（FEUrea）、およびその他分子の排泄率 fractional excretion of sodium urea and other molecules in acute kidney injury acute renal failure
• 5. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1

English Journal

• Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development.

• Del Amo EM1, Vellonen KS2, Kidron H3, Urtti A4.
• European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2015 Sep;95(Pt B):215-26. doi: 10.1016/j.ejpb.2015.01.003. Epub 2015 Jan 17.
• The aims of this research were to (1) create a curated universal database of intravitreal volumes of distribution (Vss, ivt) and clearances (CLivt) of small molecular weight compounds and macromolecules and (2) to develop quantitative structure property relationship (QSPR) and pharmacokinetic models
• PMID 25603198

• Therapeutic antisense oligonucleotides against cancer: hurdling to the clinic.

• Moreno PM1, Pêgo AP2.
• Frontiers in chemistry.Front Chem.2014 Oct 14;2:87. doi: 10.3389/fchem.2014.00087. eCollection 2014.
• Under clinical development since the early 90's and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics has not yet delivered a clinical drug to the market in the cancer field. Whilst many pre-clinical data has been generated, a lack of understanding
• PMID 25353019

• Relieving bottlenecks in RNA drug discovery for retinal diseases.

• Sullivan JM1, Yau EH, Taggart RT, Butler MC, Kolniak TA.
• Advances in experimental medicine and biology.Adv Exp Med Biol.2012;723:145-53. doi: 10.1007/978-1-4614-0631-0_20.
• PMID 22183327

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fomivirsen、fomivirsen sodium

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fomivirsen sodium

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