English Journal

Kamei J, Hosokawa T, Yanaura S, Hukuhara T.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.Nihon Yakurigaku Zasshi.1986 Jun;87(6):641-8.
Effects of naloxone on the cough depressant action of antitussive drugs were investigated in pentobarbital anesthetized male and female cats. Respiration and cough reflex were measured using a pneumotachograph via a cannula inserted into the trachea. The cough reflex was elicited by electrical stimu
PMID 2943646

Pretorius HW.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.S Afr Med J.1985 Oct 26;Suppl:30-2.
Other methods for the treatment of anxiety are discussed--psychotherapeutic, behavioural and pharmacological. Among the psychotherapeutic methods are psychoanalytical and supportive therapy, psycho-education, cognitive therapy and paradoxical intention. Behaviour- modifying methods include systemati
PMID 2865824

Effects of the antitussive fominoben (PB89) on hypoxia in chronic obstructive lung disease: comparison with dextromethorphan using a double-blind method.

Sasaki T, Sugiyama M, Sasaki H, Suzuki S, Takishima T.
The Journal of international medical research.J Int Med Res.1985;13(2):96-101.
We studied the effects of a non-narcotic, centrally acting antitussive, fominoben (PB89), on hypoxia in sixty patients suffering from chronic obstructive lung diseases (COLD), utilizing a double-blind method and using the antitussive dextromethorphan as a reference drug. By the oral administration o
PMID 3158563

Japanese Journal

亀井淳三 [他],細川友和,柳浦才三,福原武彦
日本薬理学雑誌 87(6), 641-648, 1986
… り誘発した．morphine lmg/kg の静脈内投与により咳嗽反射は5～60分後まで約90%抑制され，呼吸数は5分後より約40%抑制され，その後徐々に回復した．これらの抑制作用は, naloxone 400μg/kg 前処置により拮抗された．fominoben 5mg/kg 静脈内投与により，咳嗽反射は5分後から約80%抑制され，この抑制は15分後まで有意で30分後には回復し，呼吸数はわずかに増大した．これらの作用は，naloxone 前処置により拮抗された．dextromethorphan …
NAID 130000759694

柳浦才三 [他],北川晴美,細川友和,三澤美和
日本薬理学雑誌 82(3), 213-222, 1983
… 呼吸のRRはcodcineによって用量依存的に減少し，fominoben，dextromethorphanによって用量依存的に増加した．RAに対してcodeine，dextromethorphanはほとんど彩響を与えずfominobenはRRの場合と同様に用量依存的に興奮作用を示しeptazocineは用量依存的に抑制した．咳噺のNCに対してはcoddneは用量依存的に抑制的に作用し，fominoben，dextromethorphanは高用量で抑制的，dextromethorphanの低用量興 …
NAID 130000760833