fomepizole

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4-methylprazole, Antizole

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/11 20:23:03」(JST)

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英文文献

  • False hyperlactatemia in life-threatening ethylene glycol poisoning.
  • Riquier T1, Geri G2, Mongardon N3, Bourgogne E4, Pène F2.Author information 1Pharmacy department, Cochin Hospital, groupe hospitalier Paris Centre, assistance publique des hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France.2Medical Intensive Care Unit, Cochin Hospital, groupe hospitalier Paris Centre, assistance publique des hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, faculté de médecine, 15, rue de l'Ecole-de-Médecine, 75006 Paris, France.3Medical Intensive Care Unit, Cochin Hospital, groupe hospitalier Paris Centre, assistance publique des hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, faculté de médecine, 15, rue de l'Ecole-de-Médecine, 75006 Paris, France. Electronic address: nicolas.mongardon@cch.aphp.fr.4Toxicology department, Lariboisière Hospital, assistance publique des hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France.AbstractEthylene glycol poisoning is rare, but prompt diagnosis is crucial, in order to initiate specific treatments. Herein, we report the case of a patient who was admitted to ICU for coma and extreme metabolic acidosis with unexpected hyperlactatemia on initial ICU blood gas analyzer. Ethylene glycol poisoning was diagnosed, and hyperlactatemia was ruled out on a blood sample sent to the biochemistry department. Interference of blood gas analyzers lactate electrodes with metabolites of ethylene glycol were the source of this apparent hyperlactatemia. Symptoms gradually improved and false hyperlactatemia resolved after renal replacement therapy and fomepizole administration. Time course of ethylene glycol concentration showed similar evolution. After initial confirmation of ethylene glycol presence, this biological interference could thus be used as a surrogate of costly and highly specialised dosages.
  • Annales francaises d'anesthesie et de reanimation.Ann Fr Anesth Reanim.2014 Mar 11. pii: S0750-7658(14)00081-1. doi: 10.1016/j.annfar.2014.02.010. [Epub ahead of print]
  • Ethylene glycol poisoning is rare, but prompt diagnosis is crucial, in order to initiate specific treatments. Herein, we report the case of a patient who was admitted to ICU for coma and extreme metabolic acidosis with unexpected hyperlactatemia on initial ICU blood gas analyzer. Ethylene glycol poi
  • PMID 24630168
  • Librium for bed 1, a bottle of scotch for bed 2.
  • Welman T1, Wong JM, Le Vay R, Kader P.Author information 1Faculty of Medicine, Imperial College London, London, UK.AbstractA 47-year-old ex-nurse presented to the emergency department having consumed an unknown quantity of antifreeze. She was found to have a high level of ethylene glycol (the toxic component of antifreeze) in her bloodstream. Treatment is with either fomepizole or ethanol. She was treated with a loading dose of 2.5 mL/kg followed by 0.58 mL/kg/h of oral ethanol, equating to a maintenance dose of 35 mL of whisky every hour. She was placed on the gastroenterology ward next to two alcoholics recovering from acute withdrawal. It is important to appreciate the potential difficulties posed by scenarios of this type in order to provide optimum care both for the patient and those situated on the ward in the immediate vicinity. There is a requirement to compare the efficacies of fomepizole and ethanol therapy in the UK in order for a decision to be made on the most cost-effective first-line treatment.
  • BMJ case reports.BMJ Case Rep.2014 Mar 11;2014. pii: bcr2013202809. doi: 10.1136/bcr-2013-202809.
  • A 47-year-old ex-nurse presented to the emergency department having consumed an unknown quantity of antifreeze. She was found to have a high level of ethylene glycol (the toxic component of antifreeze) in her bloodstream. Treatment is with either fomepizole or ethanol. She was treated with a loading
  • PMID 24618869
  • Massive ethylene glycol poisoning triggers osmotic demyelination syndrome.
  • Ahmed A1, Tschetter PA1, Krasowski MD2, Engelman A1.Author information 1Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.2Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa.AbstractBACKGROUND: Ethylene glycol is a toxic organic solvent implicated in thousands of accidental and intentional poisonings each year. Osmotic demyelination syndrome (ODS) is traditionally known as a complication of the rapid correction of hyponatremia.
  • The Journal of emergency medicine.J Emerg Med.2014 Mar;46(3):e69-74. doi: 10.1016/j.jemermed.2013.08.068. Epub 2013 Nov 5.
  • BACKGROUND: Ethylene glycol is a toxic organic solvent implicated in thousands of accidental and intentional poisonings each year. Osmotic demyelination syndrome (ODS) is traditionally known as a complication of the rapid correction of hyponatremia.OBJECTIVE: Our aim was to describe how patients wit
  • PMID 24199725

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  • The Japanese journal of clinical toxicology 28(1), 31-36, 2015
  • NAID 40020391582
  • Fomepizole for the treatment of methanol poisoning

関連リンク

Fomepizole or 4-methylpyrazole is indicated for use as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. It may be used alone or in combination with hemodialysis. Apart from medical uses, the role of ...

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