WordNet

a transparent lubricating mucous membrane that covers the eyeball and the under surface of the eyelid

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1. Bウイルス感染 b virus infection
2. 新生児におけるChlamydia trachomatis感染症 chlamydia trachomatis infections in the newborn
3. 新生児単純ヘルペスウイルス感染：臨床的特徴および診断 neonatal herpes simplex virus infection clinical features and diagnosis
4. 新生児単純ヘルペスウイルス感染：管理および予防 neonatal herpes simplex virus infection management and prevention
5. 免疫能の正常な患者における発熱および発疹 fever and rash in the immunocompetent patient

English Journal

STUDIES ON THE ETIOLOGY OF SPONTANEOUS CONJUNCTIVAL FOLLICULOSIS OF RABBITS : II. BACTERIOLOGICAL INVESTIGATIONS.

Olitsky PK, Syverton JT, Tyler JR.Author information Laboratories of The Rockefeller Institute for Medical Research.AbstractBefore summarizing the experimental results presented herewith, a brief review is indicated of our study on follicular conjunctivitides existing in the different species of animals thus far examined. Spontaneous follicular conjunctivitis of monkeys and chimpanzees, which resembles the early, or follicular, stages of human trachoma, has been shown to be an infectious disease, and to arise from the action of a bacterium and not an ultramicroscopic virus (2, 10). A new species of organism, designated tentatively as Bacterium simiae, n.sp., and capable of reproducing granular lids in normal monkeys and apes, has been recovered from cultures of simian folliculosis tissues. This organism, although of a different species, is of the same genus as Bacterium granulosis which is associated with human trachoma (3). The studies were extended beyond folliculosis in monkeys and apes to a similar disease widespread among stock rabbits. Its clinical appearance and microscopic changes resemble the spontaneous malady in simians with some minor differences (1). Like the latter, rabbit folliculosis was also shown to be infectious and contagious. In the present paper a bacteriological investigation of the rabbit affection is described. In the experiments undertaken we followed the method used by Noguchi in his studies on trachoma, that is, the different organisms recovered from normal and affected conjunctivae were inoculated into the conjunctivae of selected, quarantined rabbits. Among the bacteria thus isolated from folliculosis tissue a new species was disclosed that brought about conjunctival reactions apparently indistinguishable either from the disease seen in nature or from the experimental infection induced by inoculation of folliculosis tissue. The organism was specifically active in rabbits whether injected subconjunctivally or instilled into the conjunctival sac. Furthermore, the special bacterium has thus far been cultivated only from folliculosis cases and not from other forms of conjunctivitis nor from normal tissues. Finally, specifically pathogenic strains of the identical microorganism have been recovered from rabbits experimentally infected with the bacterium. A distinctive feature of this bacterium is that it is of the same genus as the microorganisms heretofore designated as Bacterium granulosis and Bacterium simiae. It is clearly evident then that the three bacteria cultivated to this time form a new genus, for which we propose the name Noguchia. The diagnosis of the genus has already been described in this paper, but as was also shown in a foregoing section, certain specific characters differentiate the three. Accordingly, we suggest a change in the names of the granulosis and simiae species to the proposed binomials, Noguchia granulosis, n.sp., and Noguchia simiae, n.sp. The specific organism, having an evident causal relationship to rabbit folliculosis, can therefore be placed in this classification, with the name of Noguchia cuniculi, n.sp. In conclusion it would appear that in three types, at least, of follicular reactions in the conjunctiva-in man (the primary lesion of trachoma consisting essentially of follicles), in the simian, and in the rabbit-there is an intimate association of microorganisms having the same generic, but different specific properties.
The Journal of experimental medicine.J Exp Med.1934 Aug 31;60(3):375-84.
Before summarizing the experimental results presented herewith, a brief review is indicated of our study on follicular conjunctivitides existing in the different species of animals thus far examined. Spontaneous follicular conjunctivitis of monkeys and chimpanzees, which resembles the early, or foll
PMID 19870308

STUDIES ON THE ETIOLOGY OF SPONTANEOUS CONJUNCTIVAL FOLLICULOSIS OF RABBITS : I. TRANSMISSION AND FILTRATION EXPERIMENTS.

Olitsky PK, Syverton JT, Tyler JR.Author information Laboratories of The Rockefeller Institute for Medical Research.AbstractSpontaneous conjunctival folliculosis is widespread among various species of rabbits. It exists in two forms: Type I, in which the lesions are localized and the disease is relatively inactive, and Type II, in which the follicles are closely distributed over the entire surface of the conjunctivae and the affection is more active and characterized by extensive inflammatory reactions. One type can be converted into the other either by experimental methods or by natural processes. The disease can be transmitted from rabbit to rabbit by means of subconjunctival inoculation of suspensions of the affected tissues or by instillation of such material into the conjunctival sac, or even by mere contact of folliculosis animals with rabbits having smooth conjunctivae. It is plain that the disease is an infection. The causal agent of the infection is not filtrable through Seitz discs that retain Serratia marcescens nor through Berkefeld V candles that permit the passage of this organism. Furthermore, the lesions of the spontaneous or of the experimental disease do not exhibit the cytotropic effects or the inclusion bodies suggestive of the action of an ultramicroscopic virus. They are characterized, on the other hand, by a persistent and progressive chronicity and show certain resemblances to the granulomata. The evidence suggests that the spontaneous conjunctival folliculosis of rabbits is due to a microorganism-one having a low grade pathogenic action. In a paper shortly to be published, a bacterium capable of reproducing folliculosis in normal rabbits will be described.
The Journal of experimental medicine.J Exp Med.1934 Jun 30;60(1):107-18.
Spontaneous conjunctival folliculosis is widespread among various species of rabbits. It exists in two forms: Type I, in which the lesions are localized and the disease is relatively inactive, and Type II, in which the follicles are closely distributed over the entire surface of the conjunctivae and
PMID 19870281

STUDIES ON THE ETIOLOGY OF SPONTANEOUS CONJUNCTIVAL FOLLICULOSIS OF MONKEYS : II. BACTERIOLOGICAL EXPERIMENTS.

Olitsky PK, Syverton JT, Tyler JR.Author information Laboratories of The Rockefeller Institute for Medical Research.AbstractIn the bacteriological study here reported, we undertook an investigation of the flora associated with spontaneous conjunctival folliculosis. Following the plan of Noguchi (2), monkeys and chimpanzees were inoculated with the different organisms recovered from affected tissues. By this means, we disclosed among the bacteria a new species, Bacterium simiae, which was found to be specifically active, in that it induced follicular reactions in the conjunctiva apparently indistinguishable from the disease as it occurs in nature. The specific action of the bacterium in animals is the more striking when it is compared with the innocuousness of other organisms isolated from cases of folliculosis, and also when considered in relation to the behavior of quarantined animals. While the disease arises spontaneously in stock animals, of some 300 normal rhesus monkeys- these being isolated in lots of ten to twenty and quarantined from 6 to 14 weeks-not one has as yet shown folliculosis. With the insignificant exception already mentioned (1), the experimental disease was produced only when the inoculum contained either folliculosis tissue or cultures of the simian organism. Apart from these findings, the experimental results indicate that (a) the bacterium has thus far been recovered only from folliculosis cases and not from other forms of conjunctivitis nor from normal tissues; (b) the microorganism has been isolated not only from affected conjunctivae of stock monkeys but also from the tissue of animals- macaques and apes-experimentally infected with the bacterium, and (c) such recovered cultures have, in turn, been found to be specifically pathogenic in normal rhesus monkeys and chimpanzees. We may therefore postulate from this experimental study that an intimate relation exists between Bacterium simiae and spontaneous conjunctival folliculosis of simians.
The Journal of experimental medicine.J Exp Med.1933 Apr 30;57(5):871-80.
In the bacteriological study here reported, we undertook an investigation of the flora associated with spontaneous conjunctival folliculosis. Following the plan of Noguchi (2), monkeys and chimpanzees were inoculated with the different organisms recovered from affected tissues. By this means, we dis
PMID 19870166