follicular lymphoma

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/14 22:24:33」(JST)

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  • The Relationship between RUVBL1 (Pontin, TIP49, NMP238) and BCL6 in Benign and Malignant Human Lymphoid Tissues.
  • Baron BW1, Baron RM2, Baron JM3.
  • Biochemistry and biophysics reports.Biochem Biophys Rep.2016 Jul;6:1-8.
  • The human BCL6 gene, which is involved in the pathogenesis of certain human lymphomas, encodes a transcriptional repressor that is needed for germinal center B cell development and T follicular helper cell differentiation. Our goal was to identify BCL6 target genes using a cell system in which BCL6
  • PMID 27066592
  • Statin use is safe and does not impact prognosis in patient with de novo follicular lymphoma treated with immunochemotherapy: An exploratory analysis of the PRIMA cohort study.
  • Bachy E1, Estell JA2, Van de Neste E3, Bouabdallah R4, Bargay J5, Delmer A6, Gelas-Dore B7, Gomes da Silva M8, Fitoussi O9, Belada D10, Maisonneuve H11, Intragumtornchai T12, Lamy T13, Dartigues P14, Francis Seymour J15, Salles G1.
  • American journal of hematology.Am J Hematol.2016 Jun;91(4):410-5. doi: 10.1002/ajh.24305.
  • An adverse prognostic impact of statin use in lymphoma was first suspected from in vitro data showing an impairment of anti-CD20 antibody binding. However, further clinical studies suggested an improved outcome associated with their use in hematological malignancies. In particular, a survival benefi
  • PMID 26799234
  • Nodal Follicular Lymphomas: A Clinicopathological Study from a Tertiary Care Centre in South India.
  • Supari D1, Ananthamurthy A1.
  • Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2016 Jun;32(2):182-5. doi: 10.1007/s12288-015-0610-6. Epub 2015 Nov 2.
  • The aim of this study was to assess the distribution of nodal follicular lymphomas (FL) among various subtypes of non- Hodgkin lymphoma and to study their clinico-pathological features. Clinical details, histomorphology including grading & patterns and immunoprofile of 44 cases were studied. Maj
  • PMID 27065580


  • Magnified Endoscopic Features of Duodenal Follicular Lymphoma and Other Whitish Lesions
  • Iwamuro Masaya,Okada Hiroyuki,Takata Katsuyoshi,Kawai Yoshinari,Kawano Seiji,Nasu Junichiro,Kawahara Yoshiro,Tanaka Takehiro,Yoshino Tadashi,Yamamoto Kazuhide
  • Acta Medica Okayama 69(1), 37-44, 2015-02
  • … The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. … Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. …
  • NAID 120005549931
  • 濾胞性リンパ腫のhistologic gradingと特殊型,in situ病変認識の意義 (特集 悪性リンパ腫病理分類のDiscussion Pointsと合理的な治療開発)


2007年3月17日 ... 濾胞性リンパ腫は、病気の進行が比較的遅いタイプ(低悪性度)に分類され、年単位で ゆっくりとした経過をたどることが多いリンパ腫です。腫れていたリンパ節が自然に小さく なったり、別なリンパ節が腫(は)れてきたりといった「波」があります。


Follicular lymphoma Follicular Lymphoma; Lymphoma, Giant Follicular Lymphoma; Lymphoma, GiantFollicular lymphoma. The normal nodal Follicular Lymphoma. Causes, symptoms Follicular Lymphoma Histopathology Image

リンク元慢性リンパ性白血病」「bcl-2」「濾胞性リンパ腫」「follicular large-cell lymphoma」「follicular small cleaved-cell lymphoma



chronic lymphocytic leukemia, chronic lymphoid leukemia, CLL
  • first aid step1 2006 p.300,302,303,304,309,310,427,430


  • the accumulation of nonproliferating mature-appearing lymphocytes in the blood, marrow, lymph nodes, and spleen.
  • monoclonal B lymphocytes.
  • CD5+ and CD23+CD5, CD23
  • derived from memory B cell.

細胞表面マーカー WCH.2438

condition smIg CD5 CD10 CD11c CD19 CD20 CD22 CD23 CD25 CD43 CD79b CD103 FMC7
chronic lymphocytic leukemia Dim ++ -/+ ++ Dim -/+ ++ +/- -/+
Waldenstrom macroglobulinemia ++ -/+ ++ ++ -/+ +/-
prolymphocytic leukemia +++ -/+ -/+ -/+ ++ +++ ++ ++ -/+ ++
hairy cell leukemia +++ ++ +++ +++ +++ +++ +++ +++
hairy cell leukemia variant +++ ++ +++ +++ +++ +++ +++
splenic lymphoma with villous lymphocytes ++ -/+ -/+ +/- ++ ++ ++ +/- -/+ ++ -/+ ++
marginal zone B-cell lymphoma ++ +/- ++ ++ +/- +/- -/+ ++
mantle cell lymphoma ++ ++ -/+ ++ ++ ++ ++ ++
follicular lymphoma ++ -/+ ++ ++ ++ ++ -/+ ++ ++


  年齢 子供における頻度 男性(%) ステージI,II vs III,IV(%) B症状(%) 骨髄浸潤(%) 消化管浸潤(%) 5年生存率(%)
B細胞CLL/小リンパ球性リンパ腫 65 まれ 53 9 vs 91 33 72 3 51


  • 全白血病の2-3%
  • 60歳以上に多い。
  • 男女比=2:1


  • 正常な免疫グロブリンの産生が抑制されるばかりでなく、異常な自己抗体を産生 → 続発性免疫不全症、自己免疫性溶血性貧血


  • Q book p.246 42


  • 1. [charged] Epidemiology and clinical manifestations of chronic lymphocytic leukemia - uptodate [1]
  • 2. [charged] Pathologic features, diagnosis, and differential diagnosis of chronic lymphocytic leukemia - uptodate [2]
  • 3. [charged] Pathophysiology and cytogenetics of chronic lymphocytic leukemia - uptodate [3]

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bcl-2 gene, bcl-2遺伝子, bcl2遺伝子
bcl-1, bcl-2, bcl-3, bcl-6
  • IMM. 809
  • B細胞白血病では、染色体の転座により発癌性がもたらされているが、その転座の切断点がbcl-2遺伝子上にある。
  • bclはB-cell lymphoma/B-cell leukemiaの略
  • 癌遺伝子
  • ミトコンドリアの膜に結合してアポトーシスを防ぐ ← ミトコンドリア外膜の透過性亢進抑制


  • ミトコンドリア膜、小胞体

follicular lymphomaとの関連

  • 転座により免疫グロブリン遺伝子がbcl-2遺伝子とつながることでBcl-2の発現が増加。Bcl-2蛋白がB細胞系統のアポトーシスを抑制 (IMM.312)



follicular lymphoma

follicular large-cell lymphoma」



follicular lymphomafollicular mixed-cell lymphomafollicular small cleaved-cell lymphomanodular lymphoma

follicular small cleaved-cell lymphoma」



follicular large-cell lymphomafollicular lymphomafollicular mixed-cell lymphomanodular lymphoma



  • adj.
  • 濾胞性の、濾胞状の、濾胞の、卵胞の
follicleovarian follicle

WordNet   license wordnet

「of or relating to or constituting a follicle」


  [★] リンパ腫

WordNet   license wordnet

「a neoplasm of lymph tissue that is usually malignant; one of the four major types of cancer」