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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/20 10:58:42」(JST)

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Flutazolam^[1] (Coreminal, MS-4101) is a drug which is a benzodiazepine derivative. It was invented in Japan, and this is the main country in which it has been used medically. It has sedative, muscle relaxant, anticonvulsant, and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and though it's around the same potency as diazepam, it produces a more marked sedation and impaired coordination. It is indicated for the treatment of insomnia.^[2]

Flutazolam is closely related in structure to another benzodiazepine, haloxazolam.^[3]^[4]

References

^ DE Patent 1952486
^ Mitsushima T, Ueki S. Psychopharmacological effects of flutazolam (MS-4101). Nippon Yakurigaku Zasshi. 1978 Nov;74(8):959-79. (Japanese).
^ Kuwayama T, Kurono Y, Muramatsu T, Yashiro T, Ikeda K. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution. Chemical and Pharmaceutical Bulletin (Tokyo). 1986 Jan;34(1):320-6.
^ Yashiro T, Kuwayama T, Kawazura H, Suzuki T. The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system. Journal of the Pharmaceutical Society of Japan. 1987 Oct;107(10):830-4. (Japanese).

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English Journal

Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel.

Tanaka E1, Terada M, Misawa S, Wakasugi C.
Journal of chromatography. B, Biomedical applications.J Chromatogr B Biomed Appl.1996 Jun 28;682(1):173-8.
A high-performance liquid chromatographic method has been developed for the simultaneous analysis of twelve frequently used benzodiazepines (BZPs) (bromazepam, clonazepam, chlordiazepoxide, estazolam, etizolam, flutazoram, haloxazolam, lorazepam, nitrazepam, oxazolam, triazolam and diazepam, interna
PMID 8832439

[Studies on the clinical significance concerning the changes in serum pepsinogen-I and gastrin levels in aged patients with chronic gastritis].

Hamada Y1, Kamiya K, Koyama M, Asaka M, Matsushima T, Myazaki T, Kamiya T.
[Hokkaido igaku zasshi] The Hokkaido journal of medical science.Hokkaido Igaku Zasshi.1988 Mar;63(2):178-85.
Of 86 cases of aged patients with chronic gastritis treated with Trimebutine or Flutazolam, we evaluated the changes of serum pepsinogen-I and gastrin levels in their clinical courses from the points of the correlation with severity of chronic gastritis, aging phenomenon and the changes of symptom a
PMID 2898425

[The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system].

Yashiro T, Kuwayama T, Kawazura H, Suzuki T.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.Yakugaku Zasshi.1987 Oct;107(10):830-4.
PMID 2894449

Japanese Journal

Study on Raffenettis P File Format in Conventional Ab Initio Self-Consistent-Field Molecular Orbital Calculations in Parallel Computational Environment

TERAMAE Hiroyuki,OHTAWARA Kazushige
Journal of Computer Chemistry, Japan advpub(0), 0811200032, 2008
… The calculations are performed with the flutoprazepam, triazolam, clotiazepam, etizolam, and flutazolam molecules. …
NAID 130000107432

抗不安薬について(心身症に対する新しい薬物療法)(第35回日本心身医学会総会)

奥瀬哲
心身医学 35(2), 137-142, 1995-02-01
… Flutazolam was the first anti-anxiety agent in Japan that exclusively applied to the treatment of psychosomatic disorders in 1984. … Anti-anxiety agents with selective action on specific organs have been developed and marketed after Flutazolam. …
NAID 110001120432

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「フルタゾラム」

Flutazolam
Systematic (IUPAC) name
	10-chloro- 11b-(2-fluorophenyl)- 7-(2-hydroxyethyl)- 3,5-dihydro- 2H-[1,3]oxazolo [3,2-d][1,4]benzodiazepin- 6-one
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	27060-91-9
ATC code	None
PubChem	CID 3398
ChemSpider	3281
UNII	5G2K7O5D8S
KEGG	D01286
ChEMBL	CHEMBL1697836
Synonyms	13-chloro- 2-(2-fluorophenyl)- 9-(2-hydroxyethyl)- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca-1(10),11,13- trien- 8-one
Chemical data
Formula	C19H18ClFN2O3
Mol. mass	376.809
	SMILES Fc1ccccc1C42OCCN2CC(=O)N(c3c4cc(Cl)cc3)CCO;
	InChI InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2 ; Key:WMFSSTNVXWNLKI-UHFFFAOYSA-N ;
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英: flutazolam
商: コレミナール

[1] DE Patent 1952486

[2] Mitsushima T, Ueki S. Psychopharmacological effects of flutazolam (MS-4101). Nippon Yakurigaku Zasshi. 1978 Nov;74(8):959-79. (Japanese).

[3] Kuwayama T, Kurono Y, Muramatsu T, Yashiro T, Ikeda K. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution. Chemical and Pharmaceutical Bulletin (Tokyo). 1986 Jan;34(1):320-6.

[4] Yashiro T, Kuwayama T, Kawazura H, Suzuki T. The behavior of 1,4-benzodiazepine drugs in acidic media. IX. Effect of hydrolyzate of flutazolam on the central nervous system. Journal of the Pharmaceutical Society of Japan. 1987 Oct;107(10):830-4. (Japanese).

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flutazolam