出典: meddic


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「a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade names Prozac or Sarafem); it is thought to work by increasing the activity of serotonin in the brain」
fluoxetine hydrocholoride, Prozac, Sarafem

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/22 12:16:26」(JST)

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  • Corticosterone exposure augments sensitivity to the behavioral and neuroplastic effects of fluoxetine in C57BL/6 mice.
  • Robinson SA1, Brookshire BR1, Lucki I2.
  • Neurobiology of stress.Neurobiol Stress.2016 Jan 11;3:34-42. doi: 10.1016/j.ynstr.2015.12.005. eCollection 2016.
  • Both genetic background and pre-existing stress play critical roles in the effects of antidepressant drugs. The current studies showed this principal by demonstrating that exposure to the stress hormone corticosterone (CORT) allowed behavioral and neurogenic effects to emerge following chronic treat
  • PMID 26844246
  • Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells.
  • Shang W1, Liu J1, Chen R1, Ning R1, Xiong J1, Liu W1, Mao Z2, Hu G1, Yang J1.
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 May;46(5):393-405. doi: 10.3109/00498254.2015.1082209. Epub 2015 Sep 4.
  • 1. This study investigated the mechanisms of the decreases of carboxylesterases (CES) and cytochrome P4503A4 (CYP3A4) and the enzymatic activities induced by fluoxetine (FLX) in HepG2 cells. We found that FLX decreased the carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) expression and the
  • PMID 26340669
  • Interactive effects of selected pharmaceutical mixtures on bioaccumulation and biochemical status in crucian carp (Carassius auratus).
  • Ding J1, Lu G2, Li Y1.
  • Chemosphere.Chemosphere.2016 Apr;148:21-31. doi: 10.1016/j.chemosphere.2016.01.017. Epub 2016 Jan 19.
  • The aim of this study was to evaluate the interactive effects of fluoxetine (FLU), roxithromycin (ROX) and propranolol (PRP) on the bioaccumulation and biochemical responses in the crucian carp Carassius auratus. After 7 days of binary exposure (ROX + FLU and PRP + FLU), the addition of waterbor
  • PMID 26800487
  • Brain-inspired cheminformatics of drug-target brain interactome, synthesis, and assay of TVP1022 derivatives.
  • Romero-Durán FJ1, Alonso N2, Yañez M3, Caamaño O2, García-Mera X4, González-Díaz H5.
  • Neuropharmacology.Neuropharmacology.2016 Apr;103:270-8. doi: 10.1016/j.neuropharm.2015.12.019. Epub 2015 Dec 23.
  • The use of Cheminformatics tools is gaining importance in the field of translational research from Medicinal Chemistry to Neuropharmacology. In particular, we need it for the analysis of chemical information on large datasets of bioactive compounds. These compounds form large multi-target complex ne
  • PMID 26721628


  • Pharmacological Interaction With the Sigma1 (σ1)-Receptor in the Acute Behavioral Effects of Antidepressants
  • Villard Vanessa,Meunier Johann,Chevallier Nathalie,Maurice Tangui
  • Journal of Pharmacological Sciences 115(3), 279-292, 2011
  • … The SSRI fluoxetine and sertraline, but not fluvoxamine, and the tricyclic antidepressants imipramine, desipramine, and amitriptyline were also effective. …
  • NAID 130000663391
  • Simplified Heterocyclic Analogues of Fluoxetine Inhibit Inducible Nitric Oxide Production in Lipopolysaccharide-Induced BV2 Cells
  • Park Ju-Young,Kim Seung-Woo,Lee Ja-Kyeong,Im Weon Bin,Jin Byung Kwan,Yoon Sung-Hwa
  • Biological & Pharmaceutical Bulletin 34(4), 538-544, 2011
  • … A series of fluoxetine, where the N-methylamino group was replaced and then simplified, were synthesized and their inhibitory effect was tested for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells. …
  • NAID 130000657844
  • Serotonergic Modulation of Absence-Like Seizures in Groggy Rats: a Novel Rat Model of Absence Epilepsy
  • Ohno Yukihiro,Sofue Nobumasa,Imaoku Takuji,Morishita Eri,Kumafuji Kenta,Sasa Masashi,Serikawa Tadao
  • Journal of Pharmacological Sciences advpub(0), 1008200444, 2010
  • … The 5-HT reuptake inhibitors, fluoxetine and clomipramine, also inhibited the SWD generation. …
  • NAID 130000302186


Fluoxetine is approved for the treatment of major depression (including pediatric depression), obsessive-compulsive disorder (in both adult and pediatric populations), bulimia nervosa, panic disorder and premenstrual dysphoric disorder.
Fluoxetine (Floo-ox-et-een hi-droh-clor-ride) is a medicine which is used in depression, obsessive compulsive disorder and bulimia nervosa. The information in this Medicine Guide for fluoxetine varies according to the condition being treated ...
3880 円で安心の個人輸入!!SSRI抗うつ剤!副作用を抑えた第3世代 超有名ブランド ! 世界中で2000万人以上が使用していると言われるが日本未認可! 依存性が低く 軽度のうつ病によく利用!



拡張検索fluoxetine hydrochloride」「norfluoxetine



antidepressant, antidepressants


三環系抗うつ薬 tricyclic antidepressant

  • 2つの説がある。
  • 1. (急性作用)シナプス前膜におけるノルアドレナリン、セロトニンの再取り込み↓→シナプス間隙における薬剤濃度↑
  • 2. (慢性作用)(2週間後)シナプス後膜における受容体の数↓
  • 慢性作用はシナプス間隙のノルアドレナリン、セロトニン濃度が上昇した結果、シナプス後膜の受容体が減少したために出現すると考えられる。


  • 三環系
  • 四環系
ミルナシプラン milnacipran
  • 非定型抗うつ薬 atypical agent



塩酸フルオキセチン fluoxetine hydrochloride
プロザック Prozac

fluoxetine hydrochloride」

  [★] フルオキセチン塩酸フルオキセチン