fluorodeoxyuridylate

English Journal

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico models.

Honorat M1, Terreux R, Falson P, Di Pietro A, Dumontet C, Payen L.
BMC structural biology.BMC Struct Biol.2013 May 6;13:7. doi: 10.1186/1472-6807-13-7.
BACKGROUND: The Multidrug Resistance Protein ABCC11/MRP8 is expressed in physiological barriers and tumor breast tissues in which it secretes various substrates including cGMP (cyclic guanosine monophosphate) and 5FdUMP (5-fluoro-2'-deoxyuridine-5'-monophosphate), the active metabolite of the antica
PMID 23641929

Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.

Jennings-Gee J1, Pardee TS, Gmeiner WH.
Experimental hematology.Exp Hematol.2013 Feb;41(2):180-188.e4. doi: 10.1016/j.exphem.2012.10.007. Epub 2012 Oct 17.
Previous studies have indicated that 5-Fluoro-2'-deoxyuridine-5'-O-monophosphate 10mer (FdUMP[10]) displays strong antileukemic activity through the dual targeting of thymidylate synthase (TS) and DNA topoisomerase 1 (Top1). The present studies were undertaken to clarify the relationship between the
PMID 23085462

Effect of duplex drugs linking 2'-deoxy-5-fluorouridine (5-FdU) with 3'-C-ethynylcytidine (ECyd) on hepatoblastoma cell lines.

Eicher C1, Dewerth A, Ellerkamp V, Fuchs J, Schott S, Armeanu-Ebinger S.
Pediatric surgery international.Pediatr Surg Int.2013 Feb;29(2):121-7. doi: 10.1007/s00383-012-3192-5.
PURPOSE: Duplex drugs are promising anticancer agents. After in vivo cleavage into active nucleoside analogues, they exert their anti-tumour activity with reduced toxicity and side effects. Here we evaluated the impact of two duplex drugs on the viability of hepatoblastoma (HB) cells lines and their
PMID 23187893

5-fluorouracil-methotrexate synergy : Enhancement of 5-fluorodeoxyuridylate binding to thymidylate synthase by dihydropteroylpolyglutamates