flunitrazepam

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/18 04:51:40」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/08 11:13:17」(JST)

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英文文献

  • Tobacco use among 10th grade students in Istanbul and related variables.
  • Evren C1, Evren B2, Bozkurt M3.Author information 1Research, Treatment and Training Center for Alcohol and Substance Dependence (AMATEM), Bakirkoy State Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey. Electronic address: cuneytevren@yahoo.com.2Baltalimani State Hospital for Muskuloskeletal Disorders, Department of Psychiatry, Istanbul, Turkey.3Research, Treatment and Training Center for Alcohol and Substance Dependence (AMATEM), Bakirkoy State Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey.AbstractAim of this study was to determine prevalence of cigarette smoking and hookah use among 10th grade students in Istanbul, Turkey, and to compare sociodemographic, psychological and behavioral variables according to frequency of tobacco use. Cross-sectional online self-report survey conducted in 45 schools from the 15 districts in Istanbul/Turkey. The questionnaire included sections about demographic data, family characteristics, school life, psychological symptoms and use of substances including tobacco, hookah, alcohol, marijuana, volatiles, heroin, cocaine, non-prescribed legal tranquillizers (benzodiazepines, alprazolam etc.) and illegal tranquillizers (flunitrazepam). The analyses were conducted based on the 4957 subjects. Trial at least once in life is observed as 45.4% for hookah use and as 24.4% for cigarette use. Risk of hookah and cigarette use was significantly higher in male students than in female students. Frequency of tobacco use is related with various sociodemographic, psychological and behavioral variables. Our data also shows that using tobacco and alcohol increases the risk of all the other substances use and these effects are interrelated. The data suggest that there is a link between tobacco use and substance use, psychological, behavioral and social factors. There is also a strong association between tobacco use and suicidal behavior as well as self-mutilative, impulsive, hyperactive, delinquent, aggressive and behavioral problems. The illumination of these relationships may be relevant in prevention and management of tobacco use as well as important problems, such as substance use, impulsivity, hyperactivity, delinquent, aggressive self-mutilative and suicidal behavior among 10th grade students in Istanbul.
  • Asian journal of psychiatry.Asian J Psychiatr.2014 Apr;8:69-75. doi: 10.1016/j.ajp.2013.11.016. Epub 2013 Dec 1.
  • Aim of this study was to determine prevalence of cigarette smoking and hookah use among 10th grade students in Istanbul, Turkey, and to compare sociodemographic, psychological and behavioral variables according to frequency of tobacco use. Cross-sectional online self-report survey conducted in 45 sc
  • PMID 24655632
  • Effects of Genetic Polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the Steady-State Plasma Concentrations of Aripiprazole and Its Active Metabolite, Dehydroaripiprazole, in Japanese Patients with Schizophrenia.
  • Suzuki T1, Mihara K, Nakamura A, Kagawa S, Nagai G, Nemoto K, Kondo T.Author information 1Departments of *Neuropsychiatry and †Pharmacy, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.AbstractBACKGROUND:: We studied the effects of various factors, including genetic polymorphisms of the cytochrome P450 (CYP) 2D6, CYP3A5, and ABCB1, age, gender, and smoking habit on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in 89 patients with schizophrenia (46 males, 43 females).
  • Therapeutic drug monitoring.Ther Drug Monit.2014 Mar 27. [Epub ahead of print]
  • BACKGROUND:: We studied the effects of various factors, including genetic polymorphisms of the cytochrome P450 (CYP) 2D6, CYP3A5, and ABCB1, age, gender, and smoking habit on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in 89 patients with sc
  • PMID 24682161
  • Central α- and β-thujone: similar anxiogenic-like effects and differential modulation on GABAA receptors in neonatal chicks.
  • Rivera EM1, Cid MP1, Zunino P2, Baiardi G1, Salvatierra NA3.Author information 1Instituto de Investigaciones Biológicas y Tecnológicas (IIByT-CONICET), Departamento de Química, Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, Cordoba 5000, Argentina.2Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Departamento de Química, Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, 5016 Córdoba, Argentina.3Instituto de Investigaciones Biológicas y Tecnológicas (IIByT-CONICET), Departamento de Química, Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, Cordoba 5000, Argentina. Electronic address: nsalvatierra@efn.uncor.edu.AbstractThe convulsant effects of α-thujone are attributed to inhibitory actions on the GABAA receptor. We investigated, for the first time, the effects of α-thujone or β-thujone administrated centrally on the fear/anxiety behaviour of 3-day-old chicks in an Open Field and their modulation on the GABAA receptor. Higher doses were convulsant by eliciting a toxic and excitatory action, with the results showing that a dose of 78 nmol of either of the two diastereoisomers had an anxiogenic-like effect observed as an increased latency to ambulate and a reduced locomotor activity in an Open Field. Nevertheless, only the central administration of α-thujone reversed the increase induced by acute stress in the flunitrazepam-sensitive GABAA receptor recruitment. These findings demonstrated that α-thujone, when intracerebroventricularly administered, suppressed the GABAA receptor recruitment induced by acute stress, maybe due to α-thujone blocking the benzodiazepine binding site or another site of the GABAA complex. However, it should not be discarded that acute stress associated with novelty may have induced the recruitment of a subpopulation of GABAA receptors more sensitive to α-thujone than to the constitutive receptors, or that this monoterpene could have inhibited any protein or enzyme trafficking that modulated the phosphorylation of the receptor involved in the turnover of GABAA receptor. β-Thujone showed behavioural effects similar to its diastereoisomer α-thujone. However, its action mechanism may have been mediated by other neurotransmitter systems, such as the serotonergic one or by a different biological effectiveness due to a distinct stereochemistry at the specific site of the GABAA receptor.
  • Brain research.Brain Res.2014 Mar 25;1555:28-35. doi: 10.1016/j.brainres.2014.01.039. Epub 2014 Jan 30.
  • The convulsant effects of α-thujone are attributed to inhibitory actions on the GABAA receptor. We investigated, for the first time, the effects of α-thujone or β-thujone administrated centrally on the fear/anxiety behaviour of 3-day-old chicks in an Open Field and their modulation on the GABAA r
  • PMID 24486357

和文文献

  • GC/MSとLC/MSによりフルニトラゼパムおよびその代謝物が検出された2剖検例
  • USUMOTO Yosuke,KUDO Keiko,SAMESHIMA Naomi [他]
  • 犯罪学雑誌 80(2), 33-38, 2014-04
  • NAID 40020075033
  • 遅発性呼吸抑制を呈したベンゾジアゼピン大量服薬患者の1例
  • 荻野 隆史,福江 靖,岸 大次郎 [他],小平 明弘,山田 拓郎,萩原 周一,大嶋 清宏,飯野 佑一
  • 北関東医学 63(4), 365-368, 2013
  • 症例は37歳, 男性. 主訴は意識障害. 既往歴は双極性うつ病で精神科通院中であった. 家族との会話中に突然興奮状態となりベンゾジアゼピン系薬剤を大量服薬したため当院に救急搬送された. 内服した薬剤は, ロヒプノール (1) 60錠, レンドルミン (0.25) 30錠, デパス (0.5) 14錠, レスリン (25) 14錠であった. 来院時所見ではバイタル等は問題なかったが, 入院後経過は服 …
  • NAID 130003384360
  • 松本歯科大学病院歯科麻酔科における精神鎮静法症例の検討
  • 村田 賢司,谷山 貴一,丹羽 萌,大野 忠男,隅田 佐知,石田 麻依子,澁谷 徹
  • 松本歯学 38(1), 36-43, 2012-04-30
  • … The agents used for intravenous sedation were midazolam in 887 and flunitrazepam in 856 patients. …
  • NAID 120004631694

関連リンク

flunitrazepam | C16H12FN3O3 | CID 3380 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. ... NIH NLM U.S. National Library of Medicine ...
provided proper footnote in short intro ... Flunitrazepam comes in 1mg or 2mg tablets. It's oral availability is moderately high, at 64-77%, and swallowing is the most common route of administration.

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  • 睡眠薬;中程度時間作用型;ベンゾジアゼピン系
  • ベンゾジアゼピン系睡眠薬(中間型)


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