fludroxycortide

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/10 08:58:36」(JST)

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Fludroxycortide

Systematic (IUPAC) name
6-Fluoro-11,21-dihydroxy-16,17-[(l-methylethylidene)bis(oxy)]-(6α,11β,16α)-pregn-4-ene-3,20-dione
Clinical data
Trade names	Cordran, Haelan
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical
Legal status
Legal status	UK: POM (Prescription only)
Identifiers
CAS Number	1524-88-5 Y
ATC code	D07AC07 (WHO)
PubChem	CID 15209
IUPHAR/BPS	7606
DrugBank	DB00846 Y
ChemSpider	14475 Y
UNII	8EUL29XUQT Y
KEGG	D00328 Y
ChEMBL	CHEMBL1201012 N
Chemical data
Formula	C24H33FO6
Molar mass	436.514 g/mol
SMILES O=C1\C=C5/[C@](C)(CC1)[C@@H]2[C@H]([C@H]3[C@](C[C@@H]2O)([C@@]4(OC(O[C@@H]4C3)(C)C)C(=O)CO)C)C[C@@H]5F
InChI InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1 Y Key:POPFMWWJOGLOIF-XWCQMRHXSA-N Y
NY (what is this?)  (verify)

Fludroxycortide (INN, also known as flurandrenolone or flurandrenolide) is a synthetic topical steroid and is used as an anti-inflammatory treatment for use on skin irritations. Trade names include Haelan (Typharm, UK) and Cordran (by Watson Pharmaceuticals, US).

Fludroxycortide is available in ointment, cream and as an impregnated tape (Haelan tape, Cordran tape). Licensed indications in the United Kingdom include recalcitrant dermatoses.

References

English Journal

• A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.

• Antczak C1, Mahida JP, Bhinder B, Calder PA, Djaballah H.
• Journal of biomolecular screening.J Biomol Screen.2012 Aug;17(7):885-99. doi: 10.1177/1087057112446174. Epub 2012 May 9.
• Early success of kinase inhibitors has validated their use as drugs. However, discovery efforts have also suffered from high attrition rates due to lack of cellular activity. We reasoned that screening for such candidates in live cells would identify novel cell-permeable modulators for development.
• PMID 22573732

• Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen.

• Peal DS1, Mills RW, Lynch SN, Mosley JM, Lim E, Ellinor PT, January CT, Peterson RT, Milan DJ.
• Circulation.Circulation.2011 Jan 4;123(1):23-30. doi: 10.1161/CIRCULATIONAHA.110.003731. Epub 2010 Nov 15.
• BACKGROUND: Genetic long QT (LQT) syndrome is a life-threatening disorder caused by mutations that result in prolongation of cardiac repolarization. Recent work has demonstrated that a zebrafish model of LQT syndrome faithfully recapitulates several features of human disease, including prolongation
• PMID 21098441

• Flesh-colored, rubbery nodules in a young girl.

• Aboutalebi A1, Kearney DL, Metry DW.
• Pediatric dermatology.Pediatr Dermatol.2010 May-Jun;27(3):299-300. doi: 10.1111/j.1525-1470.2010.01156.x.
• PMID 20609150

Japanese Journal

• 基礎と臨床 亜急性甲状腺炎にフルドロキシコルチドテープを使用し軽快を認めた1例

• ホルモンと臨床 55(5), 497-501, 2007-05
• NAID 40015491076

• 搬痕浸潤と筋病変を伴ったサルコイドーシスの１例

• 皮膚 38(3), 347-351, 1996
• NAID 130003844038

• Betamethasone 17-Valerate含有テープ剤(ST-35)の至適濃度設定に関する比較臨床試験

• 西日本皮膚科 45(2), 235-244, 1983
• NAID 130004830587

Related Links

• Fludroxycortide: Uses, Side Effects, Interactions, Pictures ...

Find medical information for Fludroxycortide including its uses, side effects and safety, interactions, pictures, and warnings ... FLUDROXYCORTIDE INTERACTIONS Your doctor or pharmacist may already be aware of any ...

• Fludroxycortide for inflammatory skin conditions | Patient

Fludroxycortide is a moderately potent topical corticosteroid (also referred to as a topical steroid). Fludroxycortide for inflammatory skin conditions . ... Before using fludroxycortide To make sure this is the right treatment for you ...

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