fleroxacin

Fleroxacin
Systematic (IUPAC) name
	6,8-Difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	79660-72-3
ATC code	J01MA08
PubChem	CID 3357
DrugBank	DB04576
UNII	N804LDH51K
KEGG	D01716
ChEMBL	CHEMBL6273
Chemical data
Formula	C17H18F3N3O3
Mol. mass	369.34 g/mol
	SMILES CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F;
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Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/17 22:15:15」(JST)

Fleroxacin is a quinolone.^[1] It is sold under the brand names Quinodis and Megalocin.

^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy 47 (Suppl 3): 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783.

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Mjos KD1, Cawthray JF1, Polishchuk E1, Abrams MJ1, Orvig C1.
Dalton transactions (Cambridge, England : 2003).Dalton Trans.2016 Aug 16;45(33):13146-60. doi: 10.1039/c6dt01315e.
Iron is an essential nutrient for many microbes. According to the "Trojan Horse Hypothesis", biological systems have difficulties distinguishing between Fe(3+) and Ga(3+), which constitutes the antimicrobial efficacy of the gallium(iii) ion. Nine novel tris(quinolono)gallium(iii) complexes and their
PMID 27315225

Synthesis, structure, and biological evaluation of a copper(ii) complex with fleroxacin and 1,10-phenanthroline.

Xiao Y1, Wang Q1, Huang Y1, Ma X1, Xiong X1, Li H1.
Dalton transactions (Cambridge, England : 2003).Dalton Trans.2016 Jul 5;45(27):10928-35. doi: 10.1039/c6dt00915h.
A novel mixed-ligand Cu(ii) complex combined with the quinolone drug fleroxacin and 1,10-phenanthroline was synthesized in this work. The crystal structure of the complex was characterized via X-ray crystallography, which was the first reported single crystal complex of fleroxacin. Results showed th
PMID 27301999

Selective extraction and determination of fluoroquinolones in bovine milk samples with montmorillonite magnetic molecularly imprinted polymers and capillary electrophoresis.

Wang H1, Liu Y2, Wei S3, Yao S2, Zhang J4, Huang H2.
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2016 Jan;408(2):589-98. doi: 10.1007/s00216-015-9140-1. Epub 2015 Nov 5.
A sensitive and selective method for separating fluoroquinolones (FQs) from bovine milk samples was successfully developed using montmorillonite magnetic molecularly imprinted polymers (MMMIPs) as adsorbents. MMMIPs were prepared using montmorillonite as carrier, fleroxacin (FLE) as template molecul
PMID 26542835

Solution Equilibria between Aluminum(III) Ion and some Fluoroquinolone Family Members. Spectroscopic and Potentiometric Study

Djurdjevic Predrag,Joksovic Ljubinka,Jelic Ratomir [他],DJURDJEVIC Aleksandra,STANKOV Milena Jelikic
Chemical & pharmaceutical bulletin 55(12), 1689-1699, 2007-12-01
Complex formation between aluminum(III) ion and fluoroquinolone antibacterials-either moxifloxacin (4th generation antibiotic) or fieroxacin (2nd generation antibiotic) were studied in aqueous solutio …
NAID 110006532109

Visible Absorption spectra of the 4f Electron Transitions of Neodymium, Praseodymium, Holmium and Erbium Complexes with Fleroxacin and Their Analytical Application

Wang Naixing,Jiang Wei,Xu Xiuqin [他],SI Zhikun,BAI Haitao,TIAN Cong
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 18(5), 591-594, 2002-05-10
NAID 10011313227

Protective Effect of Fleroxacin against the Nephrotoxicity of Isepamicin in Rats

Yazaki Tomoko,Yoshiyama Yuji,Wong Paul [他],BEAUCHAMP Denis,KANKE Motoko
Biological & pharmaceutical bulletin 25(4), 516-519, 2002-04-01
… The protective effect of fleroxacin on isepamicin-induced nephrotoxicity was investigated. … Wistar rats were administered either fleroxacin 100 mg/kg orally, isepamicin 300 mg/kg subcutaneously, or fleroxacin and isepamicin in combination for 14 d. … However, the increase in NAG level was markedly less when isepamicin was administered in combination with fleroxacin (p<0.01). … Fleroxacin alone had no effect on urine NAG activity. …
NAID 110003638813