フィシン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/15 10:48:14」(JST)
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Ficain |
Identifiers |
EC number |
3.4.22.3 |
CAS number |
9001-33-6 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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Ficain (EC 3.4.22.3, ficin, debricin, higueroxyl delabarre) is an enzyme that is derived from figs latex.[1][2] It is of a family of proteases known as the cysteine endopeptidases, a group that also includes papain derived from papaya latex, bromelase (bromelain) extracted from pineapple stem, calpain, caspases, cathespisin B, and chymopapain. It is one of the most commonly used for differentiating many blood group antigens: For example, it destroys M, N, S, Duffy a, and Duffy b, and enhances some other antigens.
It is a common occurrence when eating the skins or the white pulp directly inside the skin of a fig to get a burning or itching sensation. This is due to the ficin in the latex (sap) of the fruit, particularly if it is unripened.
References
- ^ Liener, I.E. and Friedenson, B. (1970). "Ficin". Methods Enzymol. 19: 261–273. doi:10.1016/0076-6879(70)19020-3.
- ^ Brocklehurst, K., Willenbrock, F. and Salih, E. (1987). "Cysteine proteinases". In Neuberger, A. and Brocklehurst, K. New Comprehensive Biochemistry: Hydrolytic Enzymes. Amsterdam: Elsevier. pp. 39–158.
External links
- Ficain at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.4.22.3
Proteases: cysteine proteases (EC 3.4.22)
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Caspase |
- Caspase 1
- Caspase 2
- Caspase 3
- Caspase 4
- Caspase 5
- Caspase 6
- Caspase 7
- Caspase 8
- Caspase 9
- Caspase 10
- Caspase 12
- Caspase 13
- Caspase 14
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Fruit-derived |
- Papain
- Ficain
- Bromelain
- Actinidain
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Calpain |
- CAPN1
- CAPN2
- CAPN3
- CAPN5
- CAPN6
- CAPN7
- CAPN8
- CAPN9
- CAPN10
- CAPN11
- CAPN12
- CAPN13
- CAPN14
- CAPNS1
- CAPNS2
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Cathepsin |
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Other |
- Clostripain
- Cancer procoagulant
- Separase
- Autophagin
- Cruzipain
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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- 2. 赤血球抗原および抗体のプライマー a primer of red blood cell antigens and antibodies
English Journal
- Analysis of expression and inhibitory activity of a TrcC-6 phytocystatin present in developing and germinating seeds of triticale (×Triticosecale Wittm.).
- Simińska J1, Orzechowski S2, Bielawski W3.
- Plant physiology and biochemistry : PPB / Société française de physiologie végétale.Plant Physiol Biochem.2015 Nov;96:209-16. doi: 10.1016/j.plaphy.2015.08.005. Epub 2015 Aug 11.
- Storage proteins of cereal seeds are processed during accumulation and degraded during germination primarily by cysteine proteinases. One of the mechanisms controlling the activity of these enzymes is the synthesis of specific inhibitors named phytocystatins. Here we present the complete gene sequen
- PMID 26298807
- Multifunctional amaranth cystatin inhibits endogenous and digestive insect cysteine endopeptidases: A potential tool to prevent proteolysis and for the control of insect pests.
- Valdés-Rodríguez S1, Galván-Ramírez JP1, Guerrero-Rangel A1, Cedro-Tanda A1.
- Biotechnology and applied biochemistry.Biotechnol Appl Biochem.2015 Sep;62(5):634-41. doi: 10.1002/bab.1313. Epub 2015 Feb 6.
- In a previous study, the amaranth cystatin was characterized. This cystatin is believed to provide protection from abiotic stress because its transcription is induced in response to heat, drought, and salinity. It has also been shown that recombinant amaranth cystatin inhibits bromelain, ficin, and
- PMID 25345487
- A novel form of ficin from Ficus carica latex: Purification and characterization.
- Baeyens-Volant D1, Matagne A2, El Mahyaoui R1, Wattiez R3, Azarkan M4.
- Phytochemistry.Phytochemistry.2015 Sep;117:154-67. doi: 10.1016/j.phytochem.2015.05.019. Epub 2015 Jun 12.
- A novel ficin form, named ficin E, was purified from fig tree latex by a combination of cation-exchange chromatography on SP-Sepharose Fast Flow, Thiopropyl Sepharose 4B and fplc-gel filtration chromatography. The new ficin appeared not to be sensitive to thiol derivatization by a polyethylene glyco
- PMID 26083455
Japanese Journal
- Hiro HIRAI, Le concept de semence dans les theories de la matiere a la Renaissance: de Marsile Ficin a Pierre Gassendi (published as Volume 72 of De Diversis Artibus), (Turnhout: Brepols, 2005), 576pp, Bibliography and index
- SAKAMOTO Kuni
- Historia scientiarum. Second series : international journal of the History of Science Society of Japan 18(3), 237-242, 2009-03-31
- NAID 110007160427
- Purification and Characterization of Extracellular Cysteine Protease Inhibitor, ECPI-2, from Chlorella sp.(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Ishihara Masanobu,Shiroma Tomoaki,Taira Toki [他],Tawata Shinkichi
- Journal of bioscience and bioengineering 101(2), 166-171, 2006-02-25
- … ECPI-2 exhibited an inhibitory activity against the proteolytic activity of papain, ficin, or chymopapain, but not against stem bromelain or cathepsin B. …
- NAID 110004656717
- 紹介:エッセイレビュー H. Hirai, Le concept de semence dans les theories de la matiere a la Renaissance: de Marsile Ficin a Pierre Gassendi 平井浩『ルネサンスの物質理論における種子概念』
Related Links
- Definition of FICIN: a protease obtained from the latex of fig trees and used as an anthelmintic and protein digestive ADVERTISEMENT Origin of FICIN ... Medical Definition of FICIN : a protease that is obtained from the latex of fig ...
- Find patient medical information for FICIN on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it. ... Ficin is a latex substance from the trunk of a tree called Ficus ...
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