線維細胞
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/20 18:48:46」(JST)
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Fibrocyte |
Details |
Latin |
fibrocytus |
Identifiers |
Code |
TH H2.00.03.0.01003 |
Anatomical terminology |
A fibrocyte is an inactive mesenchymal cell, that is, a cell showing minimal cytoplasm, limited amounts of rough endoplasmic reticulum and lacks biochemical evidence of protein synthesis.
The term fibrocyte contrasts with the term fibroblast. Fibroblasts are activated connective tissue cells characterized by synthesis of proteins of the fibrous matrix, particularly the collagens. When tissue is injured, the predominant mesenchymal cells, the fibroblast, have been believed to be derived from the fibrocyte or possibly from smooth muscle cells lining vessels and glands. Commonly, fibroblasts express smooth muscle actin, a form of actin first found in smooth muscle cells and not found in resting fibrocytes. Fibroblasts expressing this form of actin are usually called "myo-fibroblasts."
Recently, the term "fibrocyte" has also been applied to a bloodborne cell able to leave the blood, enter tissue and become a fibroblast. As part of the more general topic of stem cell biology, a number of studies have suggested that the blood contains marrow derived cells that can differentiate into fibroblasts. These cells have been reported to express the hematopoietic cell surface markers CD34+, CD45+, as well as collagen. These cells can migrate to wound sites, suggesting a role in wound healing. There are several studies suggesting that fibrocytes mediate wound healing and fibrotic tissue repair.[1][2][3]
References
- ^ Yang L, et al., Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest. 2002 Sep;82(9):1183-92.
- ^ Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol. 2003 Jul 1;171(1):380-9.
- ^ Moore BB, Kolodsick JE, Thannickal VJ, Cooke K, Moore TA, Hogaboam C, Wilke CA, Toews GB. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol. 2005 Mar;166(3):675-84.
Cells in humans derived from mesoderm
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Paraxial |
Cartilage/bone/
muscle
(MSC) |
OCP |
bone: |
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cartilage: |
- Chondroblast → Chondrocyte
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Myofibroblast |
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muscle: |
- Myoblast → Myocyte
- Myosatellite cell
- Tendon cell
- Cardiac muscle cell
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adipose: |
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Digestive system |
- Interstitial cell of Cajal
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Intermediate |
Urinary system (RSC) |
- Angioblast → Endothelial cell
- Mesangial cell
- Intraglomerular
- Extraglomerular
- Juxtaglomerular cell
- Macula densa cell
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- Stromal cell → Interstitial cell → Telocytes
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- Simple epithelial cell → Podocyte
- Kidney proximal tubule brush border cell
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Reproductive system |
- Sertoli cell
- Leydig cell
- Granulosa cell
- Peg cell
- germ cells
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Lateral plate/
hemangioblast |
Blood/immune
(HSC) |
Lymphoid (CFU-L) |
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Myeloid (CFU-GEMM) |
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Circulatory system |
- Endothelial progenitor cell
- Endothelial colony forming cell
- Endothelial stem cell
- Angioblast/Mesoangioblast
- Pericyte
- Mural cell
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Index of developmental medicine
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Description |
- Embryology
- Cell lines
- endoderm
- mesoderm
- ectoderm
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Disease |
- Due to toxins
- Syndromes
- Chromosomal
- Neonate
- Twins
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UpToDate Contents
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- 1. 特発性肺線維症の病因 pathogenesis of idiopathic pulmonary fibrosis
English Journal
- Bone marrow contributions to fibrosis.
- Mackinnon A, Forbes S.SourceMRC Centre for Regenerative Medicine, University of Edinburgh, Scotland, UK.
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jul;1832(7):955-61. doi: 10.1016/j.bbadis.2013.01.022. Epub 2013 Feb 4.
- Bone marrow transplant experiments in mice using labelled donor bone marrow have indicated that following injury bone marrow derived cells can circulate and home to the injured organs. In particular fibrocytes and myofibroblasts are capable of contributing to the wound healing response, including co
- PMID 23385196
- Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model.
- Gillen JR, Zhao Y, Harris DA, Lapar DJ, Stone ML, Fernandez LG, Kron IL, Lau CL.SourceDepartment of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia.
- The Annals of thoracic surgery.Ann Thorac Surg.2013 May;95(5):1768-75. doi: 10.1016/j.athoracsur.2013.02.021. Epub 2013 Apr 2.
- BACKGROUND: Fibrocytes are integral in the development of fibroproliferative disease. The CXCL12/CXCR4 chemokine axis has been shown to play a central role in fibrocyte migration and the development of bronchiolitis obliterans (BO) after lung transplantation. Inhibition of the mammalian target of ra
- PMID 23561805
Japanese Journal
- 西岡 安彦,阿部 秀一,佐藤 正大 [他]
- Respiratory medical research 3(2), 128-131, 2015-04
- NAID 40020456861
- IL-33とアレルギー (特集 アレルギーの発症とサイトカイン)
- 肺線維症における線維芽細胞の由来 (特集 注目される呼吸器疾患の病態・診断・治療)
Related Links
- A fibrocyte is an inactive mesenchymal cell, that is, a cell showing minimal cytoplasm, limited amounts of rough endoplasmic reticulum and lacks biochemical evidence of protein synthesis. The term fibrocyte contrasts with the term fibroblast
- この学会には4日目(7月9日)まで参加してきました。学会では、血液中のfibrocyteという細胞についての講演がありました。 体の中には、組織中にコラーゲン線維(collagen fiber)を合成する線維芽細胞というものがあります。
Related Pictures
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- 英
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- 線維芽細胞