第XIII因子, factor XIII。フィブリン安定化因子
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- a white insoluble fibrous protein formed by the action of thrombin on fibrinogen when blood clots; it forms a network that traps red cells and platelets
- causing to become stable; "the family is one of the great stabilizing elements in society" (同)stabilising
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- (凝固血液中の)線維素,フィブリン
UpToDate Contents
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- 1. 稀な遺伝性凝固異常 rare inherited coagulation disorders
- 2. 後天性の凝固因子阻害物質 acquired inhibitors of coagulation
- 3. 止血の概要 overview of hemostasis
- 4. 出血症状を有する小児に対するアプローチ approach to the child with bleeding symptoms
- 5. 血漿成分の臨床使用 clinical use of plasma components
English Journal
- A common F13A1 intron 1 variant IVS1+12(A) is associated with mild FXIII deficiency in Caucasian population.
- Ivaskevicius V, Biswas A, Thomas A, Lyonga S, Rott H, Halimeh S, Kappert G, Klammroth R, Scholz U, Eberl W, Harbrecht U, Gnida C, Hertfelder HJ, Marquardt N, Oldenburg J.SourceInstitute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany, vytautas.ivaskevicius@ukb.uni-bonn.de.
- Annals of hematology.Ann Hematol.2013 Jul;92(7):975-9. doi: 10.1007/s00277-013-1724-2. Epub 2013 Mar 19.
- Mild factor XIII deficiency is an underdiagnosed coagulation disorder. Considering the large number of coding and non-coding polymorphisms identified in the F13A1 gene, there is a possibility that some of these might result in alterations of plasma FXIII levels and cause mild FXIII deficiency. Recen
- PMID 23508224
- Acquired FXIII inhibitors: a systematic review.
- Franchini M, Frattini F, Crestani S, Bonfanti C.SourceDepartment of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, Italy, massimo.franchini@aopoma.it.
- Journal of thrombosis and thrombolysis.J Thromb Thrombolysis.2013 Jul;36(1):109-14. doi: 10.1007/s11239-012-0818-3.
- Coagulation factor XIII (FXIII) is a protein that promotes fibrin stabilization by forming multiple covalent cross-links between fibrin monomers. Beside congenital FXIII deficiency, due to FXIII gene mutations, severe acquired FXIII deficiency has been described in association with autoantibodies ag
- PMID 23065324
Japanese Journal
- Factor XIII is a key molecule at the intersection of coagulation and fibrinolysis as well as inflammation and infection control
- ICHINOSE Akitada
- International journal of hematology 95(4), 362-370, 2012-04-01
- NAID 10030632320
- 臍出血に対し外科的処置を繰り返した先天性XIII因子欠損症の1新生児例
- 秋吉 潤子,水田 祥代,田口 智章 [他],山内 健,菅 尚浩,野村 明彦,大賀 正一,原 寿郎
- 日本小児外科学会雑誌 41(1), 18-22, 2005-02-20
- 症例は8生日の女児.7生日より臍出血を認め, 硝酸銀治療にて止血困難であった.一般凝固系検査は正常であり, 外科的処置を施行したが, 術後3日目より再出血を来し, Hbは7.8 g/dlまで低下した.血液凝固XIII因子が測定感度以下であり, XIII因子の補充により止血しえた.臍出血はXIII因子欠損症の初発症状として80%の症例に認めているとの報告があるが, 小児外科領域での報告は少ない.診断 …
- NAID 10015591545
- 臨床室 血液凝固第ⅩⅢ因子の低下による大腿部筋肉内血腫の1例
- 野本 智永,大坪 隆,山﨑 祐二 [他]
- 整形外科 = Orthopedic surgery 55(12), 1583-1586, 2004-11
- NAID 40019862390
Related Links
- Factor XIII or fibrin stabilizing factor is an enzyme (EC 2.3.2.13) of the blood coagulation system that crosslinks fibrin. ... Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier ...
- factor /fac·tor/ (fak´ter) an agent or element that contributes to the production of a result. accelerator factor coagulation f. V. angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic ...
Related Pictures
![Fibrin-stabilizing] deficiency of factor](https://1mg.info/0/7/a/1299.jpg)
★リンクテーブル★
| リンク元 | 「血液凝固因子」「第XIII因子」「FSF」「factor XIII」「フィブリン安定因子」 |
| 拡張検索 | 「fibrin-stabilizing factor」 |
| 関連記事 | 「fact」「factor」 |
「血液凝固因子」
- 英
- coagulation factor (Z), clotting factor, blood coagulation factor, blood coagulation factors
- 関
- ビタミンK
血液凝固因子
表
- PT.261
| 型 | 名称 | 同義語 | 分子量
(kDa) |
血漿中濃度
(μg/ml) |
半減期
(day) |
| 内因系のプロ酵素 | XII | Hageman因子 | 80 | 29 | 2 |
| プレカリクレイン | Fletcher因子 | 88 | 45 | ||
| XI | PTA | 160 | 4 | 2.5 | |
| ビタミンK依存 | VII | proconvertin | 50 | 0.5 | 0.2 |
| 凝固プロ酵素 | IX | Christmas因子 | 57 | 4 | 1 |
| X | Stuart因子 | 57 | 8 | 1.5 | |
| II | プロトロンビン | 70 | 150 | 3 | |
| 補助因子 | III | 組織因子 | 0 | ||
| 血小板ホスホリピド | |||||
| 高分子量キニノゲン | 120 | 70 | |||
| V | proaccelerin | 330 | 7 | 1.5 | |
| VIII | 抗血友病因子 | 0.5 | |||
| フィブリン堆積因子 | I | フィブリノゲン | 340 | 2500 | 4.5 |
| XIII | フィブリン安定因子 | 320 | 8 | 7 | |
| 抑制物質 | アンチトロンビンIII | 58 | 150 | 2.5 |
- 標準血液病学 p.217
- 15種類ある
| 凝固因子 | 慣用語・同義語 | ビタミンK依存 | 血液中半減期(hr) | 産生器官 | 染色体座乗部位 |
| I | fibrinogen | 100-150 | 肝臓 | 4q26 | |
| II | prothronbin | ○ | 50-80 | 肝臓 | 11p141-q12 |
| III | tissue thromboplastin | 体の各組織 | 1pter-p21 | ||
| IV | calcium ion | 肝臓 | |||
| V | labile factor/proaccelerin | 24 | 肝臓 | 1q21-q25 | |
| VII | stable factor/proconvertin | ○ | 6 | 肝臓 | 13q34 |
| VIII | antihemophilic factor | 12 | 細網系? | xq28 | |
| IX | Christmas factor | ○ | 24 | 肝臓 | xq26.3-q27.2 |
| X | Stuart factor | ○ | 25-60 | 肝臓 | 13q34 |
| XI | plasma thromboplastin antecedent | 40-80 | 肝臓 | 4q35 | |
| XII | Hageman factor | 50-70 | 肝臓 | 5q33-qter | |
| XIII | fibrin stabilizing factor | 150 | 肝臓 | 6p24-p21.3 | |
| prekallikrein | Fletcher factor | 35 | 肝臓 | 4q35 | |
| hight molecular weight kininogen | Fitzgerold factor | 150 | 肝臓 | 3q26-qter | |
| von Willebrand factor | 24 | 血管内皮
血小板 糸球体 |
12pter-p12 |
産生部位
- ほとんどが肝臓
- 例外：
臨床関連
-凝固因子
「第XIII因子」
- 英
- factor XIII, F XIII
- 同
- フィブリン安定化因子, fibrin-stabilizing factor, fibrin stabilizing factor, FSF、血漿トランスグルタミナーゼ, plasma transglutaminase、血液凝固第XIII因子、凝固第XIII因子
- 商
- フィブロガミンP
- 関
- 血液凝固因子
- トロンビンにより活性化され、フィブリン線維を架橋してフィブリン網を安定化させる血液凝固因子の一つ。
臨床関連
低下
- 先天性第XIII因子欠乏症、先天性血液凝固第XIII因子欠乏症
- ヘノッホ・シェーンライン紫斑病, Henoch-Schonlein purpura, HSP ← 要調査。乾燥濃縮ヒト血液凝固第XIII因子製剤でHSPの腹部・関節症状が改善するらしい。
- 播種性血管内凝固 DIC
- 術後縫合不全
- 潰瘍性大腸炎
- 第XIII因子インヒビター
「FSF」
[★] 第XIII因子。フィブリン安定化因子 fibrin stabilizing factor
「factor XIII」
[★] 第XIII因子。フィブリン安定化因子 fibrin stabilizing factor
「フィブリン安定因子」
「fibrin-stabilizing factor」
「fact」
- n.
「factor」
- n.