fetal hydantoin syndrome

胎児ヒダントイン症候群

WordNet

1. a pattern of symptoms indicative of some disease
2. a complex of concurrent things; "every word has a syndrome of meanings"
3. of or relating to a fetus; "fetal development" (同)foetal
4. any of a group of anticonvulsant drugs used in treating epilepsy

PrepTutorEJDIC

1. (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/10 00:17:59」(JST)

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[Wiki en表示]

Fetal hydantoin syndrome
Phenytoin
Classification and external resources
ICD-10	Q86.1
ICD-9-CM	760.77
OMIM	132810
DiseasesDB	33179

Fetal hydantoin syndrome, also called fetal dilantin syndrome is a group of defects caused to the developing fetus by exposure to the teratogenic effects of phenytoin or carbamazepine. Dilantin is the brand name of the drug phenytoin sodium in the United States, commonly used in the treatment of epilepsy.

It may also be called congenital hydantoin syndrome, Fetal Hydantoin Syndrome, Dilantin Embryopathy, or Phenytoin Embryopathy.

Association with EPHX1 has been suggested.

Signs and symptoms

About one third of children whose mothers are taking this drug during pregnancy typically have intrauterine growth restriction with a small head and develop minor dysmorphic craniofacial features and limb defects including hypoplastic nails and distal phalanges (birth defects). A smaller population will have growth problems and developmental delay, or mental retardation. Methemoglobinemia is a rarely seen side effect.

Heart defects and cleft lip may also be featured.

References

UpToDate Contents

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English Journal

• Is Neurofibromatosis Type 1-Noonan Syndrome a Phenotypic Result of Combined Genetic and Epigenetic Factors?

• Yapijakis C1, Pachis N2, Natsis S2, Voumvourakis C2.
• In vivo (Athens, Greece).In Vivo.2016 May-Jun;30(3):315-20.
• BACKGROUND/AIM: Neurofibromatosis 1-Noonan syndrome (NFNS) presents combined characteristics of both autosomal dominant disorders: NF1 and Noonan syndrome (NS). The genes causing NF1 and NS are located on different chromosomes, making it uncertain whether NFNS is a separate entity as previously sugg
• PMID 27107091

• Fetal hydantoin syndrome: A case report.

• Singh A1, Bhatia HP, Mohan A, Sharma N.
• Journal of the Indian Society of Pedodontics and Preventive Dentistry.J Indian Soc Pedod Prev Dent.2016 Jan-Mar;34(1):92-5. doi: 10.4103/0970-4388.175526.
• Fetal hydantoin syndrome (FHS) is a spectrum of defects caused to the developing fetus by exposure to the teratogenic effects of antiepileptic drug (AED) phenytoin during pregnancy. Its clinical manifestations include limb abnormalities, ocular defects, central nervous system anomalies, intrauterine
• PMID 26838156

• Fetal hydantoin syndrome and its anaesthetic implications: a case report.

• Singh R1, Kumar N, Arora S, Bhandari R, Jain A.
• Case reports in anesthesiology.Case Rep Anesthesiol.2012;2012:370412. doi: 10.1155/2012/370412. Epub 2012 Oct 2.
• Fetal hydantoin syndrome is a rare disorder that is believed to be caused by exposure of a fetus to the anticonvulsant drug phenytoin. The classic features of fetal hydantoin syndrome include craniofacial anomalies, prenatal and postnatal growth deficiencies, underdeveloped nails of the fingers and
• PMID 23082254

Japanese Journal

• Phenytoin-mediated oxidative stress in seum of female epileptics : a possible pathogenesis in fetal hydantoin syndrome

• LIU CS
• Hum Exp Toxicol 31, 61-65, 1997
• NAID 10014974867

• A case of fetal hydantoin syndrome delivered from a patient of epilepsy treated with various anti-epileptic drugs : Papers Presented from Platform

• NODA H.,NAKAMURA Y.,ITOH S.,YUHARA C.,HIRAMA T.,USUI N.,YOSHIDA K.,MITSUHASHI N.,KUWABARA Y.
• Congenital anomalies 36(3), 165, 1996-09-30
• NAID 110002787805

• Fetal hydantoin syndrome associated with congenital optic nerve hypoplasia and hypothalamic growth hormone deficiency : Abstracts of Papers Presented at the Thirty-Third Annual Meeting of the Japanese Teratology Society Nagoya, Japan, July 21-23, 1993

• SUZUKI K.,IZUMI T.,KUYAMA N.,IMAI K.,IMAIZUMI T.,FUKUYAMA Y.
• Congenital anomalies 33(3), 278, 1993-09-30
• NAID 110002787279

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★リンクテーブル★

リンク元	「胎児ヒダントイン症候群」
関連記事	「fetal」「syndrome」

「胎児ヒダントイン症候群」

　　[★]

英

fetal hydantoin syndrome

関

ヒダントイン

「fetal」

　　[★]

• adj.

• 胎生期の、胎性の、(人間)胎児の、胎児性の、(動物)胎仔の、胎仔型の

関

embryo、embryonal、embryonic、embryonic day、embryonic form、embryonic stage、fetal stage、feto、fetus、foetal、foetus

　

「syndrome」

　　[★]

• n.

• 症候群