関: dextriferron

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/04/29 20:50:52」(JST)

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Iron(II) gluconate, or ferrous gluconate,^[1] is a black compound often used as an iron supplement. It is the iron(II) salt of gluconic acid. It is marketed under brand names such as Fergon, Ferralet and Simron.^[2]

Uses

Medical

Ferrous gluconate is effectively used in the treatment of hypochromic anemia. The use of this compound compared with other iron preparations results in satisfactory reticulocyte responses, a high percentage utilization of iron, and daily increase in hemoglobin that a normal level occurs in a reasonably short time.^[3]

Food additive

Ferrous gluconate is also used as a food additive when processing black olives. It is represented by the food labeling E number E579 in Europe. It imparts a uniform jet black color to the olives.^[4] Therefore, regular consumption of blackened olives may help to keep a healthy ferritin level in the blood.

Toxicity

Ferrous gluconate may be toxic in case of overdose. Children may show signs of toxicity with ingestions of 10–20 mg/kg of elemental iron. Serious toxicity may result from ingestions of more than 60 mg/kg. Iron exerts both local and systemic effects: it is corrosive to the gastrointestinal mucosa, it can have a negative impact on the heart and blood (dehydration, low blood pressure, fast and weak pulse, shock), lungs, liver, gastrointestinal system (diarrhea, nausea, vomiting blood), nervous system (chills, dizziness, coma, convulsions, headache), and skin (flushing, loss of color, bluish-colored lips and fingernails).^[5]^[6] The symptoms may disappear in a few hours, but then emerge again after 1 or more days.^{[citation needed]}

References

^ SciToys.com ferrous gluconate information page
^ Drugs.com ferrous gluconate summary
^ Reznikoff, Paul; Goebel, Walther F. (1937). "The Use of Ferrous Gluconate in the Treatment of Hypochromic Anemia". Journal of Clinical Investigation. 16 (4): 547–54. doi:10.1172/JCI100881. PMC 424894 . PMID 16694502.
^ CSPI's Guide to Food Additives
^ Toxicity, Iron
^ Iron overdose

UpToDate Contents

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1. 成人における鉄欠乏性貧血の治療 treatment of iron deficiency anemia in adults
2. 急性鉄中毒 acute iron poisoning
3. 供血者スクリーニング：血液のレシピエントとドナーの安全性を高めるための手順とプロセス blood donor screening procedures and processes to enhance safety for the blood recipient and the blood donor
4. 患者教育：鉄不足により成人に生じる貧血（詳細） anemia caused by low iron in adults beyond the basics

English Journal

Sustainable Hydrothermal Carbonization Synthesis of Iron/Nitrogen-Doped Carbon Nanofiber Aerogels as Electrocatalysts for Oxygen Reduction.

Song LT1, Wu ZY1, Zhou F1, Liang HW1, Yu ZY1, Yu SH1.
Small (Weinheim an der Bergstrasse, Germany).Small.2016 Dec;12(46):6398-6406. doi: 10.1002/smll.201602334. Epub 2016 Sep 27.
It is urgent to develop new kinds of low-cost and high-performance nonprecious metal (NPM) catalysts as alternatives to Pt-based catalysts for oxygen reduction reaction (ORR) in fuel cells and metal-air batteries, which have been proved to be efficient to meet the challenge of increase of global ene
PMID 27671842

Effect of iron supplementation on iron stores and total body iron after whole blood donation.

Cable RG1, Brambilla D2, Glynn SA3, Kleinman S4, Mast AE5, Spencer BR6, Stone M7, Kiss JE8; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Transfusion.Transfusion.2016 Aug;56(8):2005-12. doi: 10.1111/trf.13659. Epub 2016 May 27.
BACKGROUND: Understanding the effect of blood donation and iron supplementation on iron balance will inform strategies to manage donor iron status.STUDY DESIGN AND METHODS: A total of 215 donors were randomized to receive ferrous gluconate daily (37.5 mg iron) or no iron for 24 weeks after blood don
PMID 27232535
PMID 26889525

Japanese Journal

無電解ニッケル-鉄合金めっきの浴条件と析出速度

堀田慎一,菅野正治,本間英夫
表面技術 44(3), 217-220, 1993
… The bath was less stable than an electroless nickel bath due to the formation of ferrous or ferric hydroxide precipitates. … Gluconate ion was one of the best complexing agents for stabilizing the bath.L-ascorbic acid is a mild reducing agent and inhibited the formation of ferric ions in the bath. … The deposition rate decreased with increasing ferrous sulfate content but it was possible to increase the rate by adding glycine. …
NAID 130001072456

胃内化生腸上皮細胞の中鎖中性脂肪, 糖, 鉄の吸収機能に関する生検組織学的検討

勝健一,前沢秀憲,小田倉力
日本消化器病学会雑誌 72(7), 838-845, 1975
腸上皮化生を有する原発性萎縮性胃炎患者38例を対象として内視鏡観察下に幽門洞に中鎖中性脂肪, グルコース, グルクロン酸第一鉄の水溶液を散布し10〜15分後に同部位より生検し組織化学的に前記物質の腸上皮化生組織内への取り込みについて検討した. 前記物質はそれぞれ小皮縁や細胞質内に取り込まれる事が明きらかとなつたが, 吸収上皮に酷似しているにもかかわらず吸収の見られない細胞も多く, たとえ吸収がみら …
NAID 130001062189

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リンク元	「グルコン酸第一鉄」「dextriferron」
関連記事	「ferrous」

「グルコン酸第一鉄」

Iron(II) gluconate
Names
	Systematic IUPAC name Iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid
Identifiers
CAS Number	299-29-6 ;
3D model (JSmol)	Interactive image;
ChemSpider	19953133 ;
ECHA InfoCard	100.131.978
E number	E579 (acidity regulators, ...)
PubChem CID	9291;
	InChI InChI=1S/2C6H12O7.Fe/c27-1-2(8)3(9)4(10)5(11)6(12)13;/h22-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t22-,3-,4+,5-;/m11./s1 Key: VRIVJOXICYMTAG-IYEMJOQQSA-L ; InChI=1/2C6H12O7.Fe/c27-1-2(8)3(9)4(10)5(11)6(12)13;/h22-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t22-,3-,4+,5-;/m11./s1 Key: VRIVJOXICYMTAG-QFKJHGNTBV ;
	SMILES [Fe+2].O[C@H]([C@@H](O)C([O-])=O)[C@H](O)[C@H](O)CO.[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO ;
Properties
Chemical formula	C12H22FeO14
Molar mass	446.14 g·mol−1
Appearance	Light yellow to brown powder
Odor	Slight caramel odor
Melting point	188 °C (370 °F; 461 K) dihydrate
Solubility in water	soluble
Solubility	soluble in glycerin; negligible in alcohol
Pharmacology
ATC code	B03AA03 (WHO)
Hazards
Safety data sheet	Oxford MSDS
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references