English Journal

Vaspin attenuates high glucose-induced vascular smooth muscle cells proliferation and chemokinesis by inhibiting the MAPK, PI3K/Akt, and NF-κB signaling pathways.

Li H, Peng W, Zhuang J, Lu Y, Jian W, Wei Y, Li W, Xu Y.SourceDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai 200072, China.
Atherosclerosis.Atherosclerosis.2013 May;228(1):61-8. doi: 10.1016/j.atherosclerosis.2013.02.013. Epub 2013 Feb 27.
BACKGROUND: Vaspin has insulin-sensitizing effects, as well as additional beneficial effects on metabolic diseases. However, little is known about the direct effects of vaspin on vascular complications mediated by diabetes. The objective of this study is to determine the efficacy and mechanism of va
PMID 23497782

Hervás M, Bashir Q, Leferink NG, Ferreira P, Moreno-Beltrán B, Westphal AH, Dίaz-Moreno I, Medina M, de la Rosa MA, Ubbink M, Navarro JA, van Berkel WJ.SourceInstituto de Bioquímica Vegetal y Fotosíntesis, CSIC and University of Sevilla, Spain.
The FEBS journal.FEBS J.2013 Apr;280(8):1830-40. doi: 10.1111/febs.12207. Epub 2013 Mar 25.
l-galactono-1,4-lactone dehydrogenase (GALDH) catalyzes the terminal step of vitamin C biosynthesis in plant mitochondria. Here we investigated the communication between Arabidopsis thaliana GALDH and its natural electron acceptor cytochrome c (Cc). Using laser-generated radicals we observed the fo
PMID 23438074

Mechanistic insights into the superoxide-cytochrome c reaction by lysine surface scanning.

Wegerich F, Giachetti A, Allegrozzi M, Lisdat F, Turano P.SourceBiosystems Technology, Wildau University of Applied Sciences, Wildau, Germany.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.J Biol Inorg Chem.2013 Apr;18(4):429-40. doi: 10.1007/s00775-013-0987-3. Epub 2013 Mar 3.
This study summarizes results which have been obtained by a mutational study of human cytochrome c. The protein can be used as a recognition element in analytical assays and biosensors for superoxide radicals since ferricytochrome c reacts with superoxide to form ferrocytochrome c and oxygen. Her
PMID 23455484

Japanese Journal

Structural and mechanistic roles of three consecutive Pro residues of porcine NADH-cytochrome b_5 reductase for the binding of β-NADH(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Nishimura Yuka,Shibuya Maiko,Muraki Aya [他],Takeuchi Fusako,Park Sam-Yong,Tsubaki Motonari
Journal of bioscience and bioengineering 108(4), 286-292, 2009-10-00
… These results suggested that Pro247 among the three consecutive Pro residues has the most important role for the formation of a binding site cavity and that only a slight change in the side-chain volume at this residue from Ala to Leu residue affected the electron transfer reaction from NADH and, further, on the recognition of ferricytochrome b_5. …
NAID 110007465821