関: fenoprofen calcium

WordNet

a nonsteroidal anti-inflammatory drug (trade name Nalfon) used in the treatment of arthritis and other painful inflammatory disorders (同)fenoprofen_calcium, Nalfon

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/23 13:36:09」(JST)

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Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon.

As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD.^[1]

Pharmacology

Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Contraindications

History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Drug interactions

Aminoglycosides (e.g. gentamicin): Plasma aminoglycoside levels may be elevated.
Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
Anticoagulants: Coadministration may prolong prothrombin time.
Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
Methotrexate: May increase methotrexate levels.
Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
SSRIs (e.g. fluoxetine, citalopram): The risk of GI effects may be increased.

Laboratory test interactions

False elevation in free and total serum T 3 as measured by Amerlex-M kit.

Brand names

UK - Fenopron (Typharm Limited)

References

^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 8X. ISBN 9781284057560.

External links

Fenoprofen info from Drugs.com

UpToDate Contents

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1. 非ステロイド性抗炎症剤（NSAIDs）：急性腎障害（急性腎不全）とネフローゼ
症候群 nsaids acute kidney injury acute renal failure and nephrotic syndrome
2. 成人における片頭痛の予防的治療 preventive treatment of migraine in adults
3. 微小変化群やその他のネフローゼ症候群における急性腎障害（急性腎不全） acute kidney injury acute renal failure in minimal change disease and other forms of nephrotic syndrome
4. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：胃十二指腸障害の
一次予防 nsaids including aspirin primary prevention of gastroduodenal toxicity
5. 急性間質性腎炎の臨床症状および診断 clinical manifestations and diagnosis of acute interstitial nephritis

English Journal

Separation and On-line Preconcentration of Nonsteroidal Anti-inflammatory Drugs by Microemulsion Electrokinetic Chromatography.

Chang CW1, Chen YC1, Liu CY1.
Electrophoresis.Electrophoresis.2015 Aug 8. doi: 10.1002/elps.201500160. [Epub ahead of print]
The MEEKC separation and on-line preconcentration of nonsteroidal anti- inflammatory drugs (NSAIDs) were investigated. In this work, two microemulsion (ME) systems were employed. Complete separation could be achieved at a pH of 5.5 with octane as the oil phase (ME I). The LODs for the determination
PMID 26257197

Albumin Supplement Affects the Metabolism and Metabolism-Related Drug-Drug Interaction of Fenoprofen Enantiomers.

Wang N1, Wang F2, Meng Y1, Yang GH1, Chen JW1, Wang JX3.
Chirality.Chirality.2015 Jul;27(7):436-40. doi: 10.1002/chir.22462. Epub 2015 Jun 3.
The influence of albumin towards the metabolism behavior of fenoprofen enantiomers and relevant drug-drug interaction was investigated in the present study. The metabolic behavior of fenoprofen enantiomers was compared in a phase II metabolic incubation system with and without bovine serum albumin (
PMID 26037509

Combined use of L-Alanine Tert Butyl Ester Lactate and Trimethyl-β-Cyclodextrin for the enantiomeric separations of 2-arylpropionic acids non-steroidal anti-inflammatory drugs.

Mavroudi MC1, Kapnissi-Christodoulou CP1.
Electrophoresis.Electrophoresis.2015 Jun 17. doi: 10.1002/elps.201500143. [Epub ahead of print]
In this study, a new CE method, employing a binary system of trimethyl-β-CD (TM-β-CD) and a chiral amino acid ester-based ionic liquid (AAIL), was developed for the chiral separation of seven 2-arylpropionic acid non-steroidal anti-inflammatory drugs (NSAIDs). In particular, the enantioseparation
PMID 26080944

Japanese Journal

不斉エステル化反応によるキラルな非ステロイド性抗炎症剤（NSAIDs）の新規供給法の開発

YAKUGAKU ZASSHI 132(9), 993-1000, 2012
NAID 130001888734

Biodegradation Characteristics of Pharmaceutical Substances by Whole Fungal Culture Trametes versicolor and its Laccase

Journal of Water and Environment Technology 8(2), 125-140, 2010
NAID 130000307735

Automated Analysis of Non-steroidal Anti-inflammatory Drugs in Environmental Water by On-line In-tube Solid-phase Microextraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry

環境化学 : journal of environmental chemistry 18(4), 511-520, 2008-12-16
NAID 10023990940

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リンク元	「フェノプロフェン」
拡張検索	「fenoprofen calcium」

「フェノプロフェン」

Fenoprofen
Systematic (IUPAC) name
	2-(3-phenoxyphenyl)propanoic acid
Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a681026
Pregnancy; category	US: D (Evidence of risk); C;
Routes of; administration	Oral
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Metabolism	Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Biological half-life	3 hours
Excretion	Renal (~90%)
Identifiers
CAS Number	29679-58-1
ATC code	M01AE04 (WHO)
PubChem	CID 3342
IUPHAR/BPS	4820
DrugBank	DB00573
ChemSpider	3225
UNII	RA33EAC7KY
KEGG	D02350
ChEBI	CHEBI:5004
ChEMBL	CHEMBL1297
Chemical data
Formula	C15H14O3
Molar mass	242.26986 g/mol
	SMILES O=C(O)C(c2cc(Oc1ccccc1)ccc2)C ;
	InChI InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17) ; Key:RDJGLLICXDHJDY-UHFFFAOYSA-N ;
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英: fenoprofen、fenoprofen calcium
関: フェノプロフェンカルシウム

「fenoprofen calcium」

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フェノプロフェンカルシウム

関: fenoprofen

[Ric2015-1] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 8X. ISBN 9781284057560.

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)

Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡

Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate

Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indomethacin Indomethacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†

Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam

Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ COX-inhibiting nitric oxide donator: Naproxcinod

N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin

Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†

Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap

Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

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fenoprofen