fenbendazole

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/02 17:46:52」(JST)

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Fenbendazole

Systematic (IUPAC) name
methyl N-(6-phenylsulfanyl-1H-benzoimidazol- 2-yl)carbamate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	43210-67-9
ATC code	P02CA06 QP52AC13
PubChem	CID 3334
ChemSpider	3217 Y
UNII	621BVT9M36 Y
KEGG	D04140 Y
ChEMBL	CHEMBL37161 Y
Chemical data
Formula	C15H13N3O2S
Mol. mass	299.349 g/mol
SMILES O=C(OC)Nc3nc2ccc(Sc1ccccc1)cc2n3
InChI InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) Y Key:HDDSHPAODJUKPD-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including roundworms, hookworms, whipworms, the taenia species of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.

Toxicity

Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing.^{[citation needed]} Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.^{[citation needed]}

Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD₅₀ in laboratory animals exceeds 10 g/kg when administered orally.

References

External links

• PetPlace Drug Library
• 3Dchem.com – Chemical structure

English Journal

• The Efficacy of Trichlorphon and Naphthalophos against Multiple Anthelmintic-Resistant Nematodes of Naturally Infected Sheep in Argentina.

• Fiel C, Guzman M, Steffan P, Rodriguez E, Prieto O, Bhushan C.SourceArea de Parasitologia, Facultad de Ciencias Veterinarias, UNCPBA, Campus Universitario, Tandil, Argentina, cfiel@vet.unicen.edu.ar.
• Parasitology research.Parasitol Res.2011 Aug;109 Suppl 1:139-48.
• An anthelmintic efficacy trial was conducted in sheep harbouring anthelmintic-resistant worms in Argentina. Seventy lambs were selected from a flock that had been grazed on pastures infected with trichostrongyles previously shown to be resistant to the main anthelmintic groups. Lambs were allocated
• PMID 21739383

• Antiparasitic Mebendazole Shows Survival Benefit in 2 Preclinical Models of Glioblastoma Multiforme.

• Bai RY, Staedtke V, Aprhys CM, Gallia GL, Riggins GJ.SourceLudwig Collaborative Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
• Neuro-oncology.Neuro Oncol.2011 Jul 15. [Epub ahead of print]
• Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor. During routine animal studies, we serendipitously observed that fenbendazole, a benzimidazole antihelminthic used to treat pinworm infection, inhibited brain
• PMID 21764822

Japanese Journal

• Aberrant activation of ubiquitin D at G₂ phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats

• The Journal of Toxicological Sciences 37(6), 1093-1111, 2012
• NAID 130004447011

• フェバンテルの養殖トラフグＴａｋｉｆｕｇｕ　ｒｕｂｒｉｐｅｓにおける体内濃度の経時変化

• 水産増殖 55(2), 279-284, 2007
• NAID 130003865959

• トラフグに寄生するエラムシ Heterobothrium okamotoi に対するフェバンテルの駆虫効果

• 魚病研究 41(4), 147-151, 2006-12-15
• NAID 130000065742

Related Links

• Fenbendazole - Wikipedia, the free encyclopedia

Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including roundworms, hookworms, whipworms , ...

• Fenbendazole (Panacur®) - Page 1

Fenbendazole is available over the counter but should not be administered unless under the supervision and guidance of a ... Fenbendazole is used to removal certain gastrointestinal parasites from the stomach and intestines of animals.

Related Pictures

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★リンクテーブル★

リンク元

「駆虫薬」

「駆虫薬」

　　[★]

英

anthelmintic, anthelmintics

ラ

anthelmintica

関

http://en.wikipedia.org/wiki/Anthelmintic

antiplatyhelmintic agents	Antitrematodals (schistosomicides)	binds tubulin	benzimidazole (Triclabendazole#)
		acetylcholinesterase inhibitor	phosphonic acid (metrifonate)
		Other/unknown	quinoline (praziquantel#, oxamniquine#) · phenol (bithionol) · thiazole ([[niridazole]) · arylsulfonate (stibophen)
	anticestodals (taeniacides)	binds tubulin	benzimidazole (albendazole#)
		Other/unknown	salicylanilide (niclosamide)# · aminoacridine (quinacrine) · butyrophenone (desaspidin) · chlorophenol (dichlorophen)
antinematodal agents (macrofilaricides)		binds tubulin	benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ciclobendazole, flubendazole)
		chloride channel	macrolide (ivermectin#)
		NMDA	tetrahydropyrimidine (pyrantel#, pyrantel pamoate, oxantel)
		Other/unknown	piperazine (piperazine · diethylcarbamazine#) · thiazole (levamisole#) · quinolinium (pyrvinium) · benzylammonium (bephenium) · naphthalenesulfonate (suramin#)  · tribendimidine