WordNet

relating to or having the characteristics of a family; "children of the same familial background"; "familial aggregation"
occurring among members of a family usually by heredity; "an inherited disease"; "familial traits"; "genetically transmitted features" (同)genetic, hereditary, inherited, transmitted, transmissible
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"

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Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.

Valkenburg KC1, Hostetter G2, Williams BO1.
The Prostate.Prostate.2015 Oct;75(14):1579-85. doi: 10.1002/pros.23032. Epub 2015 Jul 2.
BACKGROUND: A clinical need to better categorize patients with prostate cancer exists. The Wnt/β-catenin signaling pathway plays important roles in human prostate cancer progression. Deletion of the endogenous Wnt antagonist adenomatous polyposis coli (Apc) in mice causes high grade prostate intrae
PMID 26139199

Brosens LA1, Offerhaus GJ2, Giardiello FM3.
The Surgical clinics of North America.Surg Clin North Am.2015 Oct;95(5):1067-80. doi: 10.1016/j.suc.2015.05.004. Epub 2015 Jun 16.
Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder.
PMID 26315524

Genetic Variants That Presdispose to DNA Double-strand Breaks in Lymphocytes from a Subset of Patients With Familial Colorectal Carcinomas.

Arora S1, Yan H2, Cho I3, Fan HY3, Luo B4, Gai X5, Bodian DL6, Vockley JG6, Zhou Y7, Handorf E7, Egleston BL8, Andrake M9, Nicolas E10, Serebriiskii I11, Yen TJ2, Hall MJ12, Golemis EA13, Enders GH14.
Gastroenterology.Gastroenterology.2015 Sep 4. pii: S0016-5085(15)01259-7. doi: 10.1053/j.gastro.2015.08.052. [Epub ahead of print]
BACKROUND & AIMS: DNA structural lesions are prevalent in sporadic colorectal cancer, so we proposed that gene variants that predispose to DNA double-strand breaks (DSBs) would be found in patients with familial colorectal carcinomas of an undefined genetic basis (UFCRC).METHODS: We collected pr
PMID 26344056

佐藤将之,宮森正,服部ゆかり,小柳純子,坂祥平,村瀬樹太郎,石井信朗,西智弘,山岸正
Palliative Care Research 8(1), 511-514, 2013
【症例】40歳代, 男性. 既往に家族性大腸ポリポーシスによる大腸全摘術と腹腔内デスモイド腫瘍に対する腫瘍摘出術, 小腸大量切除の既往がある. 当院受診前まではデスモイド遺残腫瘍による腹痛と短腸症候群による下痢を自覚. 前医でフェンタニル貼付剤100 μg/時を1日5枚同時に使用しても疼痛管理は不良となり, その後はモルヒネ徐放製剤270 mg/日を中心に治療を受けていたが疼痛の訴えは続いた. 当 …
NAID 130003367227

Birt-Hogg-Dubé Syndrome and Familial Adenomatous Polyposis: An Association or a Coincidence?

Kashiwada Takeru,Shimizu Hidefumi,Tamura Kazuo,Seyama Kuniaki,Horie Yoshimasa,Mizoo Akira
Internal Medicine 51(13), 1789-1792, 2012
… An association between Birt-Hogg-Dubé syndrome (BHDS) and colon cancer remains conjectural, but herein we describe a case who may illustrate a significant link between them. … The 60-year-old woman was diagnosed at 28 years of age with colon carcinoma and familial adenomatous polyposis (FAP). … We confirmed the presence of germline mutations in both her folliculin (FLCN) and adenomatous polyposis coli (APC) genes. …
NAID 130002062197