familial combined hyperlipidemia

家族性混合型高脂血症 FCH

WordNet

1. join for a common purpose or in a common action; "These forces combined with others"
2. harvester that heads and threshes and cleans grain while moving across the field
3. add together from different sources; "combine resources"
4. relating to or having the characteristics of a family; "children of the same familial background"; "familial aggregation"
5. occurring among members of a family usually by heredity; "an inherited disease"; "familial traits"; "genetically transmitted features" (同)genetic, hereditary, inherited, transmitted, transmissible
6. made or joined or united into one

PrepTutorEJDIC

1. …'を'『結合する』,合同する / …'を'兼ね備える;(…と)…'を'兼ね合わさせる《+『名』+『with』+『名』》 / …'を'化合させる;(…と)…'を'化合させる《+『名』+『with』+『名』》 / 『結合する』,連合する,合同する / (…と)化合する《+『with』+『名』》 / 連合,合同;(特に)企業合同,政治連合 / (また『combine harvester』)(刈り取りと脱穀が同時にできる)複式収穫機,コンバイン
2. 家族の,家族特有の / 違伝的な,血統にあらわれる

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/10/26 07:34:50」(JST)

wiki en

[Wiki en表示]

Combined hyperlipidemia
Classification and external resources
Specialty	endocrinology
ICD-10	E78.4
ICD-9-CM	272.4

Combined hyperlipidemia (or -aemia) (also known as multiple-type hyperlipoproteinemia) is a commonly occurring form of hypercholesterolemia (elevated cholesterol levels) characterised by increased LDL and triglyceride concentrations, often accompanied by decreased HDL. On lipoprotein electrophoresis (a test now rarely performed) it shows as a hyperlipoproteinemia type IIB. It is the most commonly inherited lipid disorder, occurring in around one in 200 persons. In fact, almost one in five individuals who develop coronary heart disease before the age of 60 have this disorder.

The elevated triglyceride levels (>5 mmol/l) are generally due to an increase in very low density lipoprotein (VLDL), a class of lipoproteins prone to cause atherosclerosis.

Types

The two forms of this lipid disorder are:

• Familial combined hyperlipidemia (FCH) is the familial occurrence of this disorder, probably caused by decreased LDL receptor and increased ApoB.
• Acquired combined hyperlipidemia is extremely common in patients who suffer from other diseases from the metabolic syndrome ("syndrome X", incorporating diabetes mellitus type II, hypertension, central obesity and CH). Excessive free fatty acid production by various tissues leads to increased VLDL synthesis by the liver. Initially, most VLDL is converted into LDL until this mechanism is saturated, after which VLDL levels elevate.

Treatment

Both conditions are treated with fibrate drugs, which act on the peroxisome proliferator-activated receptors (PPARs), specifically PPARα, to decrease free fatty acid production. Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin), can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor expression.

See also

• Hyperlipidemia

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. LDLコレステロール代謝の遺伝性疾患 inherited disorders of ldl cholesterol metabolism
• 2. 高トリグリセライド血症 hypertriglyceridemia
• 3. 成人の家族性高コレステロール血症：概要 familial hypercholesterolemia in adults overview
• 4. 高トリグリセリド血症による急性膵炎 hypertriglyceridemia induced acute pancreatitis
• 5. 小児における脂質異常症：定義、スクリーニングおよび診断 dyslipidemia in children definition screening and diagnosis

English Journal

• Potential role of upstream stimulatory factor 1 gene variant in familial combined hyperlipidemia and related disorders.

• Auer S, Hahne P, Soyal SM, Felder T, Miller K, Paulmichl M, Krempler F, Oberkofler H, Patsch W.SourceInstitute of Pharmacology, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria. wolfgang.patsch@pmu.ac.at.
• Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2012 Jun;32(6):1535-44. Epub 2012 Mar 29.
• OBJECTIVE: Genetic studies implicated upstream stimulatory factor 1 (USF1) in familial combined hyperlipidemia because the rs2073658 minor allele was associated with reduced risk of familial combined hyperlipidemia and related disorders. The molecular mechanisms whereby rs2073658 influences trait ex
• PMID 22460558

• Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia.

• Solanas-Barca M, de Castro-Orós I, Mateo-Gallego R, Cofán M, Plana N, Puzo J, Burillo E, Martín-Fuentes P, Ros E, Masana L, Pocoví M, Civeira F, Cenarro A.SourceHospital Universitario Miguel Servet, Instituto Aragonés de Ciencias de la Salud (I+CS), Zaragoza, Spain.
• Atherosclerosis.Atherosclerosis.2012 Jun;222(2):449-55. Epub 2012 Mar 16.
• OBJECTIVE: Rare mutations in the APOE gene, undetectable with the usual genotyping technique, are responsible for dominant familial dysbetalipoproteinemia (FD) and therefore could be easily misclassified as familial combined hyperlipidemia (FCHL). We aimed to identify APOE mutations associated with
• PMID 22481068

Japanese Journal

• Retinoid X Receptor Heterodimer Variants and Cardiovascular Risk Factors

• NOHARA Atsushi,KOBAYASHI Junji,MABUCHI Hiroshi
• Journal of atherosclerosis and thrombosis 16(4), 303-318, 2009-08-31
• NAID 10025765899

• Allelic Variants of Upstream Transcription Factor 1 Associate With Carotid Artery Intima-Media Thickness : The Cardiovascular Risk in Young Finns Study

• Collings Auni,Hoyssa Salla,Fan Meng,Kahonen Mika,Hutri-Kahonen Nina,Marniemi Jukka,Juonala Markus,Viikari Jorma S.,Raitakari Olli T.,Lehtimaki Terho J.
• Circulation journal : official journal of the Japanese Circulation Society 72(7), 1158-1164, 2008-06-20
• … Background Polymorphisms of the upstream transcription factor 1 (USF1) have been associated with familial combined hyperlipidemia and coronary heart disease. …
• NAID 110006792072

Related Links

• Familial combined hyperlipidemia: MedlinePlus Medical ...

Familial combined hyperlipidemia is the most common genetic disorder that increases blood fats. It can cause early heart attacks. However, researchers have not yet found which specific genes cause it. Diabetes, alcoholism, and ...

• Familial Combined Hyperlipidemia - Medical Information ...

Familial combined hyperlipidemia is an inherited disorder that causes high cholesterol and high levels of triglycerides in the blood. It is the most common of all genetic disorders that increase blood fats, and it strikes one to two ...

Related Pictures

---

★リンクテーブル★

リンク元	「家族性高リポ蛋白血症IIb型」「家族性複合型高脂血症」「multiple lipoprotein-type hyperlipidemia」「FCHL」
関連記事	「combine」「familial」「combined」

「家族性高リポ蛋白血症IIb型」

　　[★]

同

家族性混合型高脂血症 familial combined hyperlipidemia FCHL、家族性多種リポタンパク型高脂血症 familial multiple lipoprotein-type hyperlipidemia

関

脂質異常症。複合型高脂血症

「家族性複合型高脂血症」

　　[★]

英

familial combined hyperlipidemia, familial combined hyperlipemia

同

家族性多種リポ蛋白型高脂血症 familial multiple lipoprotein type hyperlipemia

• IIb型高脂血症

「multiple lipoprotein-type hyperlipidemia」

　　[★] 多種リポタンパク質型高脂血症、多種リポ蛋白型高脂血症

関

familial combined hyperlipidemia

「FCHL」

　　[★]

同

familial combined hyperlipidemia

「combine」

　　[★]

• v.

• 併用する、組み合わせる、結合する、合併する

関

ally、associate、bind、binding、bond、bonding、combination、combined application、complicate、concomitant、concurrent、conjoin、conjugate、conjugation、conjunction、connect、connection、couple、dock、engage、engagement、join、ligate、linkage、merge、merger、symphysial、union

　 　 　 　

「familial」

　　[★]

• adj.

• 家族性の、家系性の、家族の

関

family、family member、household、kindred

　 　 　

「combined」

　　[★]

• adj.

• 混合性の

関

mixed