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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/20 23:34:51」(JST)

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Vitamin D compounds for people with chronic kidney disease not requiring dialysis.

Palmer SC1, McGregor DO, Craig JC, Elder G, Macaskill P, Strippoli GF.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2009 Oct 7;(4):CD008175. doi: 10.1002/14651858.CD008175.
BACKGROUND: Vitamin D compounds are used to suppress elevated serum parathyroid hormone (PTH) in people with chronic kidney disease (CKD).OBJECTIVES: To assess the efficacy of vitamin D therapy on biochemical, bone, cardiovascular, and mortality outcomes in people with CKD and not requiring dialysis
PMID 19821446

Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial.

Ito H1, Ogata H, Yamamoto M, Takahashi K, Shishido K, Takahashi J, Taguchi S, Kinugasa E.
Clinical nephrology.Clin Nephrol.2009 Jun;71(6):660-8.
BACKGROUND: Falecalcitriol is a novel vitamin D analog, which has a greater potential to suppress parathyroid hormone (PTH) and a longer half-life. There are few studies to compare clinical effects of oral falecalcitriol treatment with those of intravenous calcitriol treatment.METHODS: Twenty-one pa
PMID 19473635

Mazzaferro S1, Pasquali M, Conte C, Mandanici G, Muci M, Lavini R.
The International journal of artificial organs.Int J Artif Organs.2009 Feb;32(2):101-7.
The fields for clinical employment of vitamin D analogs are growing and under active evaluation in different medical specialties, ranging from dermatology to immunology and oncology. In this review we provide a brief description of the drugs that have been developed more specifically for the treatme
PMID 19363782

塚谷才明,道岸隆敏,横山邦彦,中西庸介,吉崎智一
頭頸部癌 38(4), 437-441, 2012
甲状腺癌に対して甲状腺全摘出，副甲状腺自家移植を行った20症例を対象にファレカルシトリオールを組み込んだプロトコルにて管理した。16例（80%）はプロトコル通り管理可能であった。低カルシウム血症の症状が出現した為，プロトコルを逸脱した症例は4例（20%）であったが速やかにカルシウムを投与することによってテタニーをおこした症例はなかった。全20症例で術後1週間までに血清カルシウム値の良好なコントロー …
NAID 130004510162

久保寺登
有機合成化学協会誌 68(9), 904-910, 2010-09-01
… Six active vitamin D derivatives (maxacalcitol, calcipotriol, tacalcitol, paricalcitol, doxercalciferol, and falecalcitriol) based on the findings during the third milestone are now commercially available and contributing to current clinical practice. …
NAID 10026870556

リンク元	「ファレカルシトリオール」

Falecalcitriol
Systematic (IUPAC) name
	(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Registry Number	83805-11-2
ATC code	None
PubChem	CID: 5282190
IUPHAR/BPS	2781
ChemSpider	4445383
UNII	G70A8514T8
KEGG	D01662
Chemical data
Formula	C27H38F6O3
Molecular mass	524.57 g/mol
	SMILES C[C@H](CCCC(C(F)(F)F)(C(F)(F)F)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C ;
	InChI InChI=1S/C27H38F6O3/c1-16(6-4-13-25(36,26(28,29)30)27(31,32)33)21-10-11-22-18(7-5-12-24(21,22)3)8-9-19-14-20(34)15-23(35)17(19)2/h8-9,16,20-23,34-36H,2,4-7,10-15H2,1,3H3/b18-8+,19-9-/t16-,20-,21-,22+,23+,24-/m1/s1 ; Key:XPYGGHVSFMUHLH-UUSULHAXSA-N ;
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