活性化第XIII因子
- 関
- activated factor XIII
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/24 09:40:23」(JST)
[Wiki en表示]
Factor XIII crosslinks fibrin
coagulation factor XIII,
A1 polypeptide |
| Identifiers |
| Symbol |
F13A1 |
| Alt. symbols |
F13A |
| Entrez |
2162 |
| HUGO |
3531 |
| OMIM |
134570 |
| RefSeq |
NM_000129 |
| UniProt |
P00488 |
| Other data |
| Locus |
Chr. 6 p24.2-p23 |
coagulation factor XIII,
B polypeptide |
| Identifiers |
| Symbol |
F13B |
| Entrez |
2165 |
| HUGO |
3534 |
| OMIM |
134580 |
| RefSeq |
NM_001994 |
| UniProt |
P05160 |
| Other data |
| Locus |
Chr. 1 q31-q32.1 |
Factor XIII or fibrin stabilizing factor is an enzyme (EC 2.3.2.13) of the blood coagulation system that crosslinks fibrin.
Contents
- 1 Function
- 2 Discovery
- 3 Genetics
- 4 Physiology
- 5 Diagnostic use
- 6 See also
- 7 References
- 8 External links
Function
Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. A cleavage by thrombin between residue Arg37 and Gly38 on the N-terminus of the A subunit, leads to the release of the activation peptide (MW 4000 da). In the presence of calcium the carrier subunits dissociate from the catalytic subunits, leading to a 3D change in conformation of factor XIII and hence the exposure of catalytic cysteine residue. Upon activation by thrombin, factor XIIIa acts on fibrin to form γ-glutamyl-Є-lysyl amide cross links between fibrin molecules to form an insoluble clot.[citation needed]
Discovery
FXIII is known also as Laki-Lorand factor, after the scientists who first proposed its existence in 1948.[1] A 2005 conference recommended standardization of nomenclature.[2]
Genetics
Zymogen factor XIII is a 320kDa glycoprotein tetramer consisting of twice two subunits (2 A and 2 B),[2] the genes for which are on different chromosomes:
- A subunit (6p25-p24). The transglutaminase part; this adds an alkyl group to the nitrogen on a glutamine residue, which binds in turn with a lysine on the other chain. The molecular weight of the A chain is approximately 83kDa.
- B subunit (1q31-q32.1). This has no clear enzymatic activity, and may serve as a carrier for the A subunit. The molecular weight of the B chain is approximately 76.5kDa.
Physiology
Typical concentrations of FXIII in plasma is 10 μg/ml (2A2B heterodimer), while the concentration of free B chain is 22 μg/ml. FXIII has a long half life, ranging from 5–9 days. It is present in plasma, platelets, and monocytes, as well as macrophages and bone marrow precursors of these cell types.[2]
A clot that has not been stabilized by FXIIIa is soluble in 5 mol/L urea, while a stabilized clot is resistant to this phenomenon.[1]
Diagnostic use
Factor XIII levels are not measured routinely, but may be considered in patients with an unexplained bleeding tendency. As the enzyme is quite specific for monocytes and macrophages, determination of the presence of factor XIII may be used to identify and classify malignant diseases involving these cells.[2]
See also
- Factor XIII deficiency
- D-dimer
- Coagulation
References
- ^ a b Laki K, Lóránd L (September 1948). "On the Solubility of Fibrin Clots". Science 108 (2802): 280. doi:10.1126/science.108.2802.280. PMID 17842715.
- ^ a b c d Muszbek L, Ariëns RA, Ichinose A (January 2007). "Factor XIII: recommended terms and abbreviations". J. Thromb. Haemost. 5 (1): 181–3. doi:10.1111/j.1538-7836.2006.02182.x. PMID 16938124.
External links
- Factor XIII deficiency at hemophilia.org
- med/3491 at eMedicine
|
Proteins: coagulation
|
|
| Coagulation factors |
| Primary hemostasis |
- vWF
- platelet membrane glycoproteins: Ib (A
- B
- IX)
- IIb/IIIa (IIb
- IIIa)
- VI
|
|
| Intrinsic pathway |
- HMWK/Bradykinin
- Prekallikrein/Kallikrein
- XII "Hageman"
- XI
- IX
- VIII
|
|
| Extrinsic pathway |
|
|
| Common pathway |
- X
- V
- II "(Pro)thrombin"
- I "Fibrin"
- Fibrinogen (FGA, FGG)
- XIII
|
|
|
| Coagulation inhibitors |
- Antithrombin (inhibits II, IX, X, XI, XII)
- Protein C (inhibits V, VIII)/Protein S (cofactor for protein C)
- Protein Z (inhibits X)
- ZPI (inhibits X, XI)
- TFPI (inhibits III)
|
|
| Thrombolysis/fibrinolysis |
- Plasmin
- tPA/urokinase
- PAI-1/2
- α2-AP
- α2-macroglobulin
- TAFI
|
|
|
Index of cells from bone marrow
|
|
| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
|
|
|
|
Transferases: acyltransferases (EC 2.3)
|
|
| 2.3.1: other than amino-acyl groups |
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Serotonin N-acetyl transferase
- HGSNAT
- ARD1A
- Histone acetyltransferase
- palmitoyltransferases: Carnitine O-palmitoyltransferase
- Serine C-palmitoyltransferase
- other: Acyltransferase like 2
- Aminolevulinic acid synthase
- Beta-ketoacyl-ACP synthase
- Glyceronephosphate O-acyltransferase
- Lecithin—cholesterol acyltransferase
- Glycerol-3-phosphate O-acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- ABHD5
|
|
| 2.3.2: Aminoacyltransferases |
- Gamma-glutamyl transpeptidase
- Peptidyl transferase
- Transglutaminase
- Tissue transglutaminase
- Keratinocyte transglutaminase
- Factor XIII
|
|
| 2.3.3: converted into alkyl on transfer |
- Citrate synthase
- ATP citrate lyase
- HMG-CoA synthase
- Malate synthase
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
UpToDate Contents
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English Journal
- Chronic Rhinosinusitis and the Coagulation System.
- Kim DY1, Cho SH2, Takabayashi T3, Schleimer RP4.
- Allergy, asthma & immunology research.Allergy Asthma Immunol Res.2015 Sep;7(5):421-30. doi: 10.4168/aair.2015.7.5.421. Epub 2015 May 12.
- Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults and severely affects quality of life in patients. Although various etiologic and pathogenic mechanisms of CRS have been proposed, the causes of CRS remain uncertain. Abnormalities in the coagulation cascade may play an
- PMID 26122502
- Endosulfan activates the extrinsic coagulation pathway by inducing endothelial cell injury in rats.
- Zhang L1, Wei J, Guo F, Duan J, Li Y, Shi Z, Yang Y, Zhou X, Sun Z.
- Environmental science and pollution research international.Environ Sci Pollut Res Int.2015 Jun 2. [Epub ahead of print]
- Endosulfan, a persistent organic pollutant, is widely used in agriculture as a pesticide. The aim of the present study was to evaluate the blood toxicity of different doses of endosulfan in Wistar rats. The experimental sample was composed of four groups, a control group that did not receive endosul
- PMID 26028348
- Myxoid onychomatricoma: an unusual variant of a rare nail unit tumor.
- Stewart CL1, Sobanko JF, Rubin AI.
- The American Journal of dermatopathology.Am J Dermatopathol.2015 Jun;37(6):473-6. doi: 10.1097/DAD.0000000000000270.
- A 57-year-old woman presented with a 3-year history of a thickened, yellowed, over-curved nail plate of the left second toe. The proximal nail fold had an associated nodule. When observed head-on, the distal nail plate demonstrated multiple circular perforations. Avulsion of the nail plate revealed
- PMID 25830718
Japanese Journal
- Recombinant gamma T305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'a' and calcium binding sites
- 毛包成分に富む Fibrous Papule of the Nose の１例
Related Links
- factor [fak´ter] an agent or element that contributes to the production of a result. accelerator factor factor V, one of the coagulation factors. factor I see ... They are then covalently cross-linked by factor XIIIa at the outer D domains of ...
- Haematologic Technologies, Inc is a primary manufacturer of high-quality coagulation proteins and research reagents including factor XIIIa. ... * inferred from the zymogen, factor XIII References 1. McDonaugh, J., in ...
Related Pictures
★リンクテーブル★
[★]
活性化第XIII因子
- 関
- factor XIIIa
[★]
- 英
- factor XIIIa、activated factor XIII
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter