WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the 4th letter of the Roman alphabet (同)d

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
deuteriumの化学記号
(おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/26 18:10:24」(JST)

wiki en

Factor D also known as complement factor D(CFD) or adipsin a protein which in humans is encoded by the CFD gene.^[2] Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.

Function

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.^[2]

Alternative pathway. ( 4. Is factor D cleaving B to Bb and Ba)

Factor D is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis.^[3]

Clinical significance

The level of Factor D is elevated in the obese, this elevation may be due to high activity or resistance but exact cause is not totally known.

Structure

All members of the chymotrypsin family of serine proteases have very similar structures. In all cases, including factor D, there is two antiparallel β-barrel domains with each barrel containing six β-strands with the same typology in all enzymes. The major difference in backbone structure between Factor D and the other serine proteases of the chymotrpsin family is in the surface loops connecting the secondary structural elements. Factor D displays different conformations of major catalytic and substrate-binding residues typically found in the chrotrypsin family. These features suggest the catalytic activity of factor D is prohibited unless conformational changes are induced by a realignment.^[4]

References

^ PDB 1HFD; Narayana SV, Carson M, el-Kabbani O, et al. (January 1994). "Structure of human factor D. A complement system protein at 2.0 A resolution". J. Mol. Biol. 235 (2): 695–708. doi:10.1006/jmbi.1994.1021. PMID 8289289.
^ ^a ^b "Entrez Gene: CFD". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1675.
^ Ronti T, Lupattelli G, Mannarino E (April 2006). "The endocrine function of adipose tissue: an update". Clin. Endocrinol. (Oxf) 64 (4): 355–65. doi:10.1111/j.1365-2265.2006.02474.x. PMID 16584505. Lay summary – medscape.com.
^ Volanakis JE, Narayana SV (April 1996). "Complement factor D, a novel serine protease". Protein Sci. 5 (4): 553–64. doi:10.1002/pro.5560050401. PMC 2143395. PMID 8845746. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2143395/.

External links

Complement+Factor+D at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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English Journal

Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration.

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Anti-factor D (AFD; FCFD4514S, lampalizumab) is a humanized IgG Fab fragment directed against factor D (fD), a rate-limiting serine protease in the alternative complement pathway (AP). Evaluation of AFD as a potential intravitreal (IVT) therapeutic for dry age-related macular degeneration patients w
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Platelet-derived growth factor-D (PDGF-D) was recently identified, and acts as potent mitogen for mesenchymal cells. PDGF-D also induces cellular transformation and promotes tumor growth. However, the functional role of PDGF-D in adipose-derived stem cells (ASCs) has not been identified. Therefore,
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Circulating Angiogenesis Biomarkers Are Associated With Disease Progression in Lung Adenocarcinoma.

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PMID 25301368

Japanese Journal

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Related Pictures

★リンクテーブル★

リンク元	「D因子」「補体D因子」
拡張検索	「vascular endothelial growth factor D」「complement factor D」
関連記事	「D」「fact」「factor」

「D因子」

complement factor D (adipsin)
	Factor D in Homo sapiens
Identifiers
Symbol	CFD
Alt. symbols	DF, PFD
Entrez	1675
HUGO	2771
OMIM	134350
RefSeq	NM_001928
UniProt	P00746
Other data
Locus	Chr. 19 p13.3

　　[★]

英: factor D, D
同: C3プロアクチベーター転換酵素、活性化D因子
関: 第二経路、C3, C3b, B, C3bBb, C3a

「補体D因子」

　　[★]

英: complement factor D、factor D
関: D因子、補体因子D

「vascular endothelial growth factor D」

　　[★]

血管内皮増殖因子D、血管内皮細胞増殖因子D

関: VEGF-D

「complement factor D」

　　[★]

補体D因子、補体因子D

関: factor D

「D」

　　[★]

アスパラギン酸
ジヒドロウリジン
遠位の distal,
うつ病 depression
下行結腸 descending colon(大腸内視鏡検査の結果を記載するときに用いる)

「fact」

　　[★]

n.

事実、現状、実際、実態

関: actual、actually、in fact、in practice、indeed、practically

「factor」

　　[★]

n.

因子、要因、要素、ファクター

関: element、elementary、factorial、parameter

[pmid8289289-1] PDB 1HFD; Narayana SV, Carson M, el-Kabbani O, et al. (January 1994). "Structure of human factor D. A complement system protein at 2.0 A resolution". J. Mol. Biol. 235 (2): 695–708. doi:10.1006/jmbi.1994.1021. PMID 8289289.

[entrez-2] "Entrez Gene: CFD". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1675.

[pmid16584505-3] Ronti T, Lupattelli G, Mannarino E (April 2006). "The endocrine function of adipose tissue: an update". Clin. Endocrinol. (Oxf) 64 (4): 355–65. doi:10.1111/j.1365-2265.2006.02474.x. PMID 16584505. Lay summary – medscape.com.

[pmid8845746-4] Volanakis JE, Narayana SV (April 1996). "Complement factor D, a novel serine protease". Protein Sci. 5 (4): 553–64. doi:10.1002/pro.5560050401. PMC 2143395. PMID 8845746. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2143395/.

匿名

検索

案内

案内

factor D