WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the 2nd letter of the Roman alphabet (同)b
- the blood group whose red cells carry the B antigen (同)type_B, group B
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/03/01 04:43:37」(JST)
[Wiki en表示]
| CFB |
|
| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
|
3HS0, 1DLE, 1Q0P, 1RRK, 1RS0, 1RTK, 2OK5, 2WIN, 2XWB, 2XWJ, 3HRZ
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| Identifiers |
| Aliases |
CFB, Cfb, AI195813, AI255840, B, Bf, C2, Fb, H2-Bf, AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, PBF2, complement factor B |
| External IDs |
MGI: 105975 HomoloGene: 1292 GeneCards: CFB |
| Gene location (Human) |
|
| Chr. |
Chromosome 6 (human)[1] |
|
|
| Band |
6p21.33 |
Start |
31,945,650 bp[1] |
| End |
31,952,084 bp[1] |
|
| Gene location (Mouse) |
|
| Chr. |
Chromosome 17 (mouse)[2] |
|
|
| Band |
17 B1|17 18.41 cM |
Start |
34,856,374 bp[2] |
| End |
34,862,518 bp[2] |
|
| RNA expression pattern |
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| More reference expression data |
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| Gene ontology |
| Molecular function |
• peptidase activity
• serine-type peptidase activity
• serine-type endopeptidase activity
• hydrolase activity
• complement binding
• protein binding
|
| Cellular component |
• extracellular region
• plasma membrane
• blood microparticle
• extracellular exosome
• extracellular space
|
| Biological process |
• complement activation
• regulation of complement activation
• proteolysis
• immune system process
• complement activation, alternative pathway
• innate immune response
|
| Sources:Amigo / QuickGO |
|
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
|
|
| Ensembl |
ENSG00000243570
ENSG00000239754
ENSG00000243649
ENSG00000241253
ENSG00000242335
|
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ENSG00000241534
ENSG00000204359
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
|
|
| Location (UCSC) |
Chr 6: 31.95 – 31.95 Mb |
Chr 6: 34.86 – 34.86 Mb |
| PubMed search |
[3] |
[4] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
|
Complement factor B is a protein that in humans is encoded by the CFB gene.[5]
Contents
- 1 Function
- 2 References
- 3 Further reading
- 4 External links
Function
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.[5]
Alternative pathway. (Some labels are in Polish.)
Complement tests
| C4 (C) |
FB (A) |
C3 |
CH50 |
Conditions |
| · |
↓ |
↓ |
↓ |
PSG, C3 NeF AA |
| ↓ |
· |
↓ |
· |
HAE, C4D |
| · |
· |
· |
↓ |
TCPD |
| ↓ |
· /↓ |
↓ |
↓ |
SLE |
| ↑ |
↑ |
↑ |
↑ |
inflammation |
References
- ^ a b c ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534, ENSG00000204359 GRCh38: Ensembl release 89: ENSG00000243570, ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534, ENSG00000204359 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090231 - Ensembl, May 2017
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ a b "Entrez Gene: CFB complement factor B".
Further reading
- Ambrus JL, Peters MG, Fauci AS, Brown EJ (March 1990). "The Ba fragment of complement factor B inhibits human B lymphocyte proliferation". Journal of Immunology. 144 (5): 1549–53. PMID 2307833.
- Bradley DT, Zipfel PF, Hughes AE (June 2011). "Complement in age-related macular degeneration: a focus on function". Eye. 25 (6): 683–93. doi:10.1038/eye.2011.37. PMC 3178140 . PMID 21394116.
- Campbell RD (January 1987). "The molecular genetics and polymorphism of C2 and factor B". British Medical Bulletin. 43 (1): 37–49. PMID 3315100.
- Campbell RD, Bentley DR, Morley BJ (September 1984). "The factor B and C2 genes". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 306 (1129): 367–78. doi:10.1098/rstb.1984.0097. PMID 6149579.
- Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Experimental and Clinical Immunogenetics. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631.
- Rawal N, Pangburn MK (March 2001). "Structure/function of C5 convertases of complement". International Immunopharmacology. 1 (3): 415–22. doi:10.1016/S1567-5769(00)00039-4. PMID 11367526.
- Arnason A, Larsen B, Marshall WH, Edwards JH, Macintosh P, Olaisen B, Teisberg P (August 1977). "Very close linkage between HLA-B and Bf inferred from allelic association". Nature. 268 (5620): 527–8. doi:10.1038/268527a0. PMID 889587.
- Barnum SR, Ishii Y, Agrawal A, Volanakis JE (October 1992). "Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG". The Biochemical Journal. 287. 287 ( Pt 2): 595–601. PMC 1133207 . PMID 1445220.
- Yancey KB, Overholser O, Domloge-Hultsch N, Li LJ, Caughman SW, Bisalbutra P (March 1992). "Human keratinocytes and A-431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway". The Journal of Investigative Dermatology. 98 (3): 379–83. doi:10.1111/1523-1747.ep12499812. PMID 1545147.
- Niemann MA, Bhown AS, Miller EJ (March 1991). "The principal site of glycation of human complement factor B". The Biochemical Journal. 274. 274 ( Pt 2): 473–80. PMC 1150163 . PMID 2006911.
- Davrinche C, Abbal M, Clerc A (1991). "Molecular characterization of human complement factor B subtypes". Immunogenetics. 32 (5): 309–12. doi:10.1007/bf00211644. PMID 2249879.
- Farries TC, Lachmann PJ, Harrison RA (August 1988). "Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement". The Biochemical Journal. 253 (3): 667–75. PMC 1149358 . PMID 3140783.
- Wu LC, Morley BJ, Campbell RD (January 1987). "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements". Cell. 48 (2): 331–42. doi:10.1016/0092-8674(87)90436-3. PMID 3643061.
- Campbell RD, Porter RR (July 1983). "Molecular cloning and characterization of the gene coding for human complement protein factor B". Proceedings of the National Academy of Sciences of the United States of America. 80 (14): 4464–8. doi:10.1073/pnas.80.14.4464. PMC 384059 . PMID 6308626.
- Morley BJ, Campbell RD (January 1984). "Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen". The EMBO Journal. 3 (1): 153–7. PMC 557312 . PMID 6323161.
- Christie DL, Gagnon J (January 1983). "Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment". The Biochemical Journal. 209 (1): 61–70. PMC 1154056 . PMID 6342610.
- Mole JE, Anderson JK, Davison EA, Woods DE (March 1984). "Complete primary structure for the zymogen of human complement factor B". The Journal of Biological Chemistry. 259 (6): 3407–12. PMID 6546754.
- Woods DE, Markham AF, Ricker AT, Goldberger G, Colten HR (September 1982). "Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product". Proceedings of the National Academy of Sciences of the United States of America. 79 (18): 5661–5. doi:10.1073/pnas.79.18.5661. PMC 346964 . PMID 6957884.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Mejía JE, Jahn I, de la Salle H, Hauptmann G (January 1994). "Human factor B. Complete cDNA sequence of the BF*S allele". Human Immunology. 39 (1): 49–53. doi:10.1016/0198-8859(94)90100-7. PMID 8181962.
External links
- GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
- OMIM entries on Atypical Hemolytic-Uremic Syndrome
- The MEROPS online database for peptidases and their inhibitors: S01.196
- Complement Factor B at the US National Library of Medicine Medical Subject Headings (MeSH)
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PDB gallery
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1dle: FACTOR B SERINE PROTEASE DOMAIN
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1q0p: A domain of Factor B
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1rrk: Crystal Structure Analysis of the Bb segment of Factor B
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1rs0: Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)
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1rtk: Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid
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2ok5: Human Complement factor B
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Proteins: complement system (C, L, A)
|
| Activators/enzymes |
| Early |
- A: Factor B
- Factor D
- Factor P/Properdin
|
| Middle |
- C3-convertase
- C5-convertase
|
| Late |
|
|
| Inhibitors |
- CLA: C1-inhibitor
- Decay-accelerating factor/CD59
- Factor I
|
| Complement receptors |
- CR1
- CR2
- CR3
- CR4
- CD11b/CD11c/CD18
- Anaphylatoxin
|
|
Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
|
| Digestive enzymes |
- Enteropeptidase
- Trypsin
- Chymotrypsin
- Elastase
|
| Coagulation |
- factors: Thrombin
- Factor VIIa
- Factor IXa
- Factor Xa
- Factor XIa
- Factor XIIa
- Kallikrein
- PSA
- KLK1
- KLK2
- KLK3
- KLK4
- KLK5
- KLK6
- KLK7
- KLK8
- KLK9
- KLK10
- KLK11
- KLK12
- KLK13
- KLK14
- KLK15
- fibrinolysis: Plasmin
- Plasminogen activator
- Tissue plasminogen activator
- Urinary plasminogen activator
|
| Complement system |
- Factor B
- Factor D
- Factor I
- MASP
- C3-convertase
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| Other immune system |
- Chymase
- Granzyme
- Tryptase
- Proteinase 3/Myeloblastin
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| Venombin |
|
| Other |
- Acrosin
- Prolyl endopeptidase
- Pronase
- Proprotein convertases
- Prostasin
- Reelin
- Subtilisin/Furin
- Streptokinase
- S1P
- Cathepsin
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia.
- Dash BC1, Thomas D2, Monaghan M3, Carroll O4, Chen X5, Woodhouse K6, O'Brien T5, Pandit A7.
- Biomaterials.Biomaterials.2015 Oct;65:126-39. doi: 10.1016/j.biomaterials.2015.06.037. Epub 2015 Jun 26.
- Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced inflammation are the two major pathophysiological changes that occur in the is
- PMID 26151745
- Effects of 11-ketotestosterone and temperature on inhibin subunit mRNA levels in the ovary of the shortfinned eel, Anguilla australis.
- Zadmajid V1, Falahatimarvast A2, Damsteegt EL2, Setiawan AN2, Ozaki Y2, Shoae A2, Lokman PM3.
- Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.Comp Biochem Physiol B Biochem Mol Biol.2015 Sep;187:14-21. doi: 10.1016/j.cbpb.2015.04.012. Epub 2015 May 7.
- Members of the transforming growth factor-b (TGFb) superfamily are important during early oogenesis in mammals. In this study, we tested whether documented effects of 11-ketotestosterone (11KT) on previtellogenic eel ovaries are mediated through affecting the expression of key ovarian TGFb genes. Fu
- PMID 25958821
Japanese Journal
- Importance of interstory velocity on optimal along-height allocation of viscous oil dampers in super high-rise buildings
- Adachi Fuyuki,Fujita Kohei,Tsuji Masaaki,Takewaki Izuru
- Engineering Structures 56, 489-500, 2013-11-00
- … It is concluded that the demand of relief forces of oil dampers is expressed in terms of (a) the maximum story shear forces of a frame without oil dampers which can be evaluated by the response spectrum method or other conventional methods, (b) the damper damping ratio, (c) the damping correction factor and (d) the higher-mode correction factor. …
- NAID 120005302071
- 専門知識のないユーザを対象とした情報セキュリティ技術に関する安心感の構造
- 西岡 大,齊藤 義仰,村山 優子
- 情報処理学会論文誌 54(9), 2197-2207, 2013-09-15
- 社会全体で情報セキュリティ技術に対し安心・安全が求められている傾向にある.情報セキュリティ技術の分野では,安全な技術を提供すれば利用者は安心するという論理の下,技術の安全性を確保するための議論に主眼が置かれており,安心感の構造について十分な議論がされていない.我々は,ユーザ調査において知識のないユーザの意見を反映した質問紙を作成し,因子分析と多変量分散分析から,情報セキュリティ技術に関する知識のな …
- NAID 110009605628
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★リンクテーブル★
[★]
- 関
- complement-regulatory protein
[★]
- 英
- factor B, B
- 同
- C3プロアクチベーター
[★]
血管内皮増殖因子B、血管内皮細胞増殖因子B
- 関
- VEGF-B
[★]
補体B因子、B因子、補体因子B
- 関
- factor B
[★]
- Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter