ezetimibe

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/31 12:30:16」(JST)

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英文文献

  • Impact of efavirenz on intestinal metabolism and transport: insights from an interaction study with ezetimibe in healthy volunteers.
  • Oswald S, Meyer Zu Schwabedissen HE, Nassif A, Modess C, Desta Z, Ogburn ET, Mostertz J, Keiser M, Jia J, Hubeny A, Ulrich A, Runge D, Marinova M, Lütjohann D, Kroemer HK, Siegmund W.SourceDepartment of Clinical Pharmacology, Ernst-Moritz-Arndt-University, Greifswald, Germany.
  • Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2012 Mar;91(3):506-13. doi: 10.1038/clpt.2011.255. Epub 2012 Feb 1.
  • Hypercholesterolemia frequently occurs in patients treated with efavirenz who cannot be treated adequately with statins because of drug interactions. These patients may benefit from cholesterol-lowering therapy with ezetimibe. This study determined the influence of single-dose and multiple-dose efav
  • PMID 22297387
  • Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis.
  • Hardwick RN, Fisher CD, Street SM, Canet MJ, Cherrington NJ.Source1703 E. Mabel St., Tucson, AZ 85721. cherrington@pharmacy.arizona.edu.
  • Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2012 Mar;40(3):450-60. Epub 2011 Nov 23.
  • Ezetimibe (EZE) lowers serum lipid levels by blocking cholesterol uptake in the intestine. Disposition of EZE and its pharmacologically active glucuronide metabolite (EZE-GLUC) to the intestine is dependent on hepatobiliary efflux. Previous studies suggested that hepatic transporter expression and f
  • PMID 22112382

和文文献

  • Effect of Statin Therapy in 4-Year-Old Dichorionic Diamniotic Twins with Familial Hypercholesterolemia Showing Multiple Xanthomas
  • Erratum for Renal and Vascular Protective Effects of Ezetimibe in Chronic Kidney Disease
  • Formulation and in Vitro Evaluation of Self-microemulsifying Drug Delivery System Containing Fixed-Dose Combination of Atorvastatin and Ezetimibe

関連リンク

Ezetimibe / ɛ ˈ z ɛ t ɨ m ɪ b / is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol), when other cholesterol-lowering ...
Ezetimibe may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache dizziness diarrhea sore throat runny nose sneezing joint pain Some side effects can be serious. The ...

関連画像

ezetimibe ppt 636kb ezetimibe zip 352kb ezetimibe ppt 636kb ezetimibe zip 352kb Figure 5. and Production With Ezetimibe/SimvastatinEzetimibe/Simvastatin Dual ActionCholesterol Absorption


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リンク元エゼチミブ

エゼチミブ」

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ezetimibe
ゼチーア(バイエル)
高脂血症治療薬
  • コレステロールトランスポーター阻害薬

作用機序

  • Niemann-Pick C1-Like1(NPC1L1)を選択的に阻害 → コレステロール吸収を抑制
  • コレステロールの吸収に関する輸送体である






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