eye disorder

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eye diseaseophthalmopathy

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英文文献

  • The α1 adrenoceptor antagonist prazosin enhances sleep continuity in fear-conditioned Wistar-Kyoto rats.
  • Laitman BM1, Gajewski ND2, Mann GL2, Kubin L2, Morrison AR2, Ross RJ3.Author information 1Department of Animal Biology, School of Veterinary Medicine, Philadelphia, PA, United States. Electronic address: benjamin.laitman@mssm.edu.2Department of Animal Biology, School of Veterinary Medicine, Philadelphia, PA, United States.3Veterans Affairs Medical Center, Philadelphia, PA, United States; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Animal Biology, School of Veterinary Medicine, Philadelphia, PA, United States.AbstractFragmentation of rapid eye movement sleep (REMS) is well described in individuals with posttraumatic stress disorder (PTSD) and likely has significant functional consequences. Fear-conditioned rodents may offer an attractive model of the changes in sleep that characterize PTSD. Following fear conditioning (FC), Wistar-Kyoto (WKY) rats, a strain known to be particularly stress-sensitive, have increased REMS fragmentation that can be quantified as a shift in the distribution of REMS episodes towards the more frequent occurrence of sequential REMS (inter-REMS episode interval≤3 min) vs. single REMS (interval>3 min). The α1 adrenoceptor antagonist prazosin has demonstrated efficacy in normalizing sleep in PTSD. To determine the utility of fear-conditioned WKY rats as a model of sleep disturbances typical of PTSD and as a platform for the development of new treatments, we tested the hypothesis that prazosin would reduce REMS fragmentation in fear-conditioned WKY rats. Sleep parameters and freezing (a standard measure of anxiety in rodents) were quantified at baseline and on Days 1, 7, and 14 following FC, with either prazosin (0.01mg/kg, i.p.) or vehicle injections administered prior to testing in a between-group design. Fear conditioning was achieved by pairing tones with a mild electric foot shock (1.0mA, 0.5s). One, 7, and 14 days following FC, prazosin or vehicle was injected, the tone was presented, freezing was measured, and then sleep was recorded from 11 AM to 3 PM. WKY rats given prazosin, compared to those given vehicle, had a lower amount of seq-REMS relative to total REMS time 14 days after FC. They also had a shorter non-REMS latency and fewer non-REMS arousals at baseline and on Days 1 and 7 after FC. Thus, in FC rats, prazosin reduced both REMS fragmentation and non-REMS discontinuity.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Mar 3;49:7-15. doi: 10.1016/j.pnpbp.2013.11.004. Epub 2013 Nov 15.
  • Fragmentation of rapid eye movement sleep (REMS) is well described in individuals with posttraumatic stress disorder (PTSD) and likely has significant functional consequences. Fear-conditioned rodents may offer an attractive model of the changes in sleep that characterize PTSD. Following fear condit
  • PMID 24246572
  • A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye.
  • Nagai N1, Kaji H2, Onami H3, Ishikawa Y1, Nishizawa M2, Osumi N4, Nakazawa T5, Abe T6.Author information 1Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.2Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan.3Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan; Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.4Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.5Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.6Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. Electronic address: toshi@oph.med.tohoku.ac.jp.AbstractThe design of drug delivery systems that can deliver multiple drugs to the posterior segment of the eye is a challenging task in retinal disease treatments. We report a polymeric device for multi-drug transscleral delivery at independently controlled release rates. The device comprises a microfabricated reservoir, controlled-release cover and three different fluorescent formulations, which were made of photopolymeized tri(ethyleneglycol)dimethacrylate (TEGDM) and poly(ethyleneglycol)dimethacrylate (PEGDM). The release rate of each fluorescent is controlled by varying the PEGDM/TEGDM ratio in its formulation and the cover. The release kinetics appeared to be related to the swelling ratio of the PEGDM/TEGDM polymers. When the devices were implanted onto rat sclerae, fluorescence was observable in the ocular tissues during 4weeks' implantation and distributed locally around the implantation site. Our polymeric system, which can administer multiple compounds with distinct kinetics, provides prolonged action and less invasive transscleral administration, and is expected to provide new tools for the treatment of posterior eye diseases with new therapeutic modalities.
  • Acta biomaterialia.Acta Biomater.2014 Feb;10(2):680-7. doi: 10.1016/j.actbio.2013.11.004. Epub 2013 Nov 15.
  • The design of drug delivery systems that can deliver multiple drugs to the posterior segment of the eye is a challenging task in retinal disease treatments. We report a polymeric device for multi-drug transscleral delivery at independently controlled release rates. The device comprises a microfabric
  • PMID 24239899
  • Deficits in response inhibition correlate with oculomotor control in children with fetal alcohol spectrum disorder and prenatal alcohol exposure.
  • Paolozza A1, Rasmussen C2, Pei J2, Hanlon-Dearman A3, Nikkel SM4, Andrew G5, McFarlane A6, Samdup D1, Reynolds JN7.Author information 1Centre for Neuroscience Studies, Queens University, Kingston, ON, Canada.2Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.3Manitoba FASD Centre, Winnipeg, MB, Canada.4Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.5Glenrose Rehabilitation Hospital, Edmonton, AB, Canada.6Lakeland Centre for FASD, Cold Lake, AB, Canada.7Centre for Neuroscience Studies, Queens University, Kingston, ON, Canada. Electronic address: jnr@queensu.ca.AbstractChildren with fetal alcohol spectrum disorder (FASD) or prenatal alcohol exposure (PAE) frequently exhibit impairment on tasks measuring inhibition. The objective of this study was to determine if a performance-based relationship exists between psychometric tests and eye movement tasks in children with FASD. Participants for this dataset were aged 5-17 years and included those diagnosed with an FASD (n=72), those with PAE but no clinical FASD diagnosis (n=21), and typically developing controls (n=139). Participants completed a neurobehavioral test battery, which included the NEPSY-II subtests of auditory attention, response set, and inhibition. Each participant completed a series of saccadic eye movement tasks, which included the antisaccade and memory-guided tasks. Both the FASD and the PAE groups performed worse than controls on the subtest measures of attention and inhibition. Compared with controls, the FASD group made more errors on the antisaccade and memory-guided tasks. Among the combined FASD/PAE group, inhibition and switching errors were negatively correlated with direction errors on the antisaccade task but not on the memory-guided task. There were no significant correlations in the control group. These data suggests that response inhibition deficits in children with FASD/PAE are associated with difficulty controlling saccadic eye movements which may point to overlapping brain regions damaged by prenatal alcohol exposure. The results of this study demonstrate that eye movement control tasks directly relate to outcome measures obtained with psychometric tests that are used during FASD diagnosis, and may therefore help with early identification of children who would benefit from a multidisciplinary diagnostic assessment.
  • Behavioural brain research.Behav Brain Res.2014 Feb 1;259:97-105. doi: 10.1016/j.bbr.2013.10.040. Epub 2013 Nov 1.
  • Children with fetal alcohol spectrum disorder (FASD) or prenatal alcohol exposure (PAE) frequently exhibit impairment on tasks measuring inhibition. The objective of this study was to determine if a performance-based relationship exists between psychometric tests and eye movement tasks in children w
  • PMID 24185031

和文文献

  • 経過良好な、マイコプラズマ感染症関連Opsoclonus-Myoclonus症候群の1例
  • 河野 香,伊藤 康,石塚 喜世伸,西川 愛子,佐原 真澄,平野 嘉子,石垣 景子,舟塚 真,高橋 幸利,大澤 眞木子
  • 東京女子医科大学雑誌 83(E1), E336-E341, 2013-01-31
  • Opsoclonus-myoclonus syndrome(OMS)は,左右共同性の不規則で多方向性の異常眼球運動,顔面,頭部,体幹などに出現するmyoclonus,小脳失調を特徴とする症候群である.小児において,腫瘍,感染,予防接種などが誘因となり,半数に神経芽細胞腫を合併する.症例は4歳9ヵ月の女児.生後11ヵ月時にマイコプラズマ感染を契機にOMSを発症した.血清マイコプラズマ抗体価(PA法) …
  • NAID 110009559410
  • プロスタグランジン製剤過剰点眼により角膜障害をきたした1例
  • ?田 幸尚,岡田 由香,藤田 識人 [他]
  • 眼科臨床紀要 5(12), 1134-1136, 2012-12-00
  • NAID 40019527278
  • サリン被害後の眼科的後遺症
  • 岩佐 真弓,井上 賢治,若倉 雅登
  • あたらしい眼科 = Journal of the eye
  • NAID 10031120871

関連リンク

Eye disorder remedy - Keeping good eye health with eye care devices such as EyeRelax can be used to improve many an eye disorder such as myopia, presbyopia, astigmatism, amblyopia etc.
It's coald "Mouche volantes", it's the rest of an artery nat nutured the front part of the eye during embyonal development. When this development is done, the artery regresses, little parts of it stay there though, that's what ...

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Human Eye DiseasesCommon Eye Disorders Eye disorders that with major eye disorders,Trevino Eye Clinic - Laredo, Texas - Eye eye diseases and disordersEye Diseases and Disorders | E-books on


★リンクテーブル★
リンク元ophthalmopathy」「eye disease」「眼疾患
関連記事eye」「disorder」「eyed」「e」「eyes

ophthalmopathy」

  [★]

  • n.
  • 眼疾患、眼障害、眼症
eye diseaseeye disorder


eye disease」

  [★]

eye disorderophthalmopathy


眼疾患」

  [★]

eye disorder
眼症



eye」

  [★]

WordNet   license wordnet

「look at」
eyeball

WordNet   license wordnet

「a small hole or loop (as in a needle); "the thread wouldn''t go through the eye"」

WordNet   license wordnet

「the organ of sight」
oculus, optic

WordNet   license wordnet

「attention to what is seen; "he tried to catch her eye"」

WordNet   license wordnet

「good discernment (either visually or as if visually); "she has an eye for fresh talent"; "he has an artist''s eye"」

PrepTutorEJDIC   license prepejdic

「〈C〉(人・動物の器官としての)『目』 / 〈C〉(まぶた・まつ毛・まゆ毛などを含めて,外側からみえる)『目』,目の周り / 〈C〉(目の)虹彩 / 〈C〉『視力』,視覚 / 〈C〉《単数形で》『視線』,まなざし / 〈C〉《しばしば複数形で》警戒(観察,監視)の目 / 〈C〉《通例単数形で》(…に対する)鑑識眼,物を見る目,(…を)見分ける力《+『for』+『名』》 / 〈C〉《しばしば複数形で》物の見方;観点 / 〈C〉目に似たようなもの(じゃがいもの芽・クジャクの羽の眼状の点など) / 〈C〉針の目,めど / 〈C〉(かぎ・ホックの)受け / 〈C〉台風の目 / (好奇・疑いなどの目で)…‘を'じろじろ見る,注意して見る」


disorder」

  [★]

  • 障害:個人的苦痛や機能の障害があるので「疾病」とは言えるものの、その背景にある臓器障害がもう一つはっきりしない場合に用いられる。(PSY.9)
  • n.
  • an untidy state; a lack of order or organization (⇔order)
  • violent behaviour of large groups of people
  • an illness that cause a part of the body to stop functioning correctly
  • 注意
disease <> illness <> disorder
  • vt.
  • 乱す、乱雑にする。(人)の(心身の)調子を狂わせる。
  • vi.

WordNet   license wordnet

「bring disorder to」
disarray

WordNet   license wordnet

「a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time"」
upset

WordNet   license wordnet

「a disturbance of the peace or of public order」

PrepTutorEJDIC   license prepejdic

「〈U〉『無秩序』,混乱,乱雑(confusion) / 《しばしば複数形で》(社会的・政治的な)粉争,騒動 / 〈C〉(肉体的・精神的な)不調,異常,障害 / …‘の'秩序を乱す / 〈心身〉‘に'異常を起こさせる」


eyed」

  [★]

WordNet   license wordnet

「having an eye or eyes or eyelike feature especially as specified; often used in combination; "a peacock''s eyed feathers"; "red-eyed"」


e」

  [★]

WordNet   license wordnet

「the base of the natural system of logarithms; approximately equal to 2.718282...」


eyes」

  [★]

WordNet   license wordnet

「opinion or judgment; "in the eyes of the law"; "I was wrong in her eyes"」




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