English Journal

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

Koay HF1, Gherardin NA1,2, Enders A3, Loh L1, Mackay LK1,4, Almeida CF1, Russ BE1, Nold-Petry CA5,6, Nold MF5,6, Bedoui S1, Chen Z1, Corbett AJ1, Eckle SB1, Meehan B1, d'Udekem Y7, Konstantinov IE7, Lappas M8,9, Liu L10,11, Goodnow CC3, Fairlie DP10,11, Rossjohn J12,13,14, Chong MM15, Kedzierska K1, Berzins SP1,16,17, Belz GT18,19, McCluskey J1, Uldrich AP1,4, Godfrey DI1,4, Pellicci DG1,4.
Nature immunology.Nat Immunol.2016 Nov;17(11):1300-1311. doi: 10.1038/ni.3565. Epub 2016 Sep 26.
Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives presented by the antigen-presenting molecule MR1. Here we defined three developmental stages and checkpoints for the MAIT cell lineage in humans and mice. Stage 1 and stage 2 MAIT cells predominated in thymus,
PMID 27668799

Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells.

Szurek E1, Cebula A1, Wojciech L1, Pietrzak M2, Rempala G2, Kisielow P3, Ignatowicz L1.
PloS one.PLoS One.2015 Oct 23;10(10):e0141161. doi: 10.1371/journal.pone.0141161. eCollection 2015.
Helios transcription factor and semaphorin receptor Nrp-1 were originally described as constitutively expressed at high levels on CD4+Foxp3+ T regulatory cells of intrathymic origin (tTregs). On the other hand, CD4+Foxp3+ Tregs generated in the periphery (pTregs) or induced ex vivo (iTregs) were rep
PMID 26495986

Fluorochrome-based definition of naturally occurring Foxp3(+) regulatory T cells of intra- and extrathymic origin.

Petzold C1, Steinbronn N, Gereke M, Strasser RH, Sparwasser T, Bruder D, Geffers R, Schallenberg S, Kretschmer K.
European journal of immunology.Eur J Immunol.2014 Dec;44(12):3632-45. doi: 10.1002/eji.201444750. Epub 2014 Sep 23.
Under physiological conditions, studies on the biology of naturally induced Foxp3(+) Treg cells of intra- and extrathymic origin have been hampered by the lack of unambiguous markers to discriminate the mature progeny of such developmental Treg-cell sublineages. Here, we report on experiments in dou
PMID 25159127

Japanese Journal

TCR alpha beta^+ CD4^- CD8^- T cells differentiate extrathymically in a lck-independent manner and participate in early response against Listeria monocytogenes infection through interferon-gamma production