WordNet

to conduct a test or investigation; "We are experimenting with the new drug in order to fight this disease"
the act of conducting a controlled test or investigation (同)experimentation
a venture at something new or different; "as an experiment he decided to grow a beard"
the testing of an idea; "it was an experiment in living"; "not all experimentation is done in laboratories" (同)experimentation
try something new, as in order to gain experience; "Students experiment sexually"; "The composer experimented with a new style" (同)try out
relating to or based on experiment; "experimental physics"
relying on observation or experiment; "experimental results that supported the hypothesis" (同)data-based, observational
of the nature of or undergoing an experiment; "an experimental drug"
any of several malignant neoplasms (usually of the skin) consisting of melanocytes (同)malignant_melanoma

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Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.

da Cruz EH1, Silvers MA2, Jardim GA1, Resende JM1, Cavalcanti BC3, Bomfim IS3, Pessoa C4, de Simone CA5, Botteselle GV6, Braga AL6, Nair DK7, Namboothiri IN7, Boothman DA2, da Silva Júnior EN8.
European journal of medicinal chemistry.Eur J Med Chem.2016 Oct 21;122:1-16. doi: 10.1016/j.ejmech.2016.06.019. Epub 2016 Jun 14.
Selenium-containing quinone-based 1,2,3-triazoles were synthesized using click chemistry, the copper catalyzed azide-alkyne 1,3-dipolar cycloaddition, and evaluated against six types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), PC3 (human p
PMID 27341379

Phase I dose-finding study of monotherapy with atezolizumab, an engineered immunoglobulin monoclonal antibody targeting PD-L1, in Japanese patients with advanced solid tumors.

Mizugaki H1, Yamamoto N2, Murakami H3, Kenmotsu H3, Fujiwara Y1, Ishida Y4, Kawakami T4, Takahashi T3.
Investigational new drugs.Invest New Drugs.2016 Oct;34(5):596-603. doi: 10.1007/s10637-016-0371-6. Epub 2016 Jul 1.
Background Atezolizumab is an engineered immunoglobulin monoclonal antibody that targets the programmed death-1/programmed death-ligand 1 pathway. Methods In this phase I dose-finding study, we assessed the safety, feasibility, pharmacokinetics (PK), and exploratory anti-tumor activity of atezolizum
PMID 27363843

Clue to Understanding the Janus Behavior of Eumelanin: Investigating the Relationship between Hierarchical Assembly Structure of Eumelanin and Its Photophysical Properties.

Ju KY1, Kang J2, Chang JH2, Lee JK1.
Biomacromolecules.Biomacromolecules.2016 Sep 12;17(9):2860-72. doi: 10.1021/acs.biomac.6b00686. Epub 2016 Aug 9.
The contradictory biological function of eumelanin (photoprotection vs photosensitization) has long been a topic of debate in a wide range of disciplines such as chemistry, physics and biology. For understanding full spectrum of eumelanin's photobiological aspect, revealing how eumelanin's complex s
PMID 27459629

MAVS-dependent IRF3/7 bypass of interferon p-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells

Takaki Hiromi,Honda Kenya,Atarashi Koji,Kobayashi Fukiko,Ebihara Takashi,Oshiumi Hiroyuki,Matsumoto Misako,Shingai Masashi,Seya Tsukasa
Molecular immunology 57(2), 100-109, 2014-02
… RNA virus infection usually allows cells to generate double-stranded RNA and induce activation of IFN regulatory factor (IRF) 3/7 transcription factors, leading to the production of type I IFN through the retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5)-mitochondrial antiviral signaling protein (MAVS) pathway. … In mouse experimental BMDCs models, we found CD150Tg/Mavs(-/-)BMDCs, but not CD150Tg/Irf3(-/-)/Irf7-/-BMDCs, permissive to MV. …
NAID 120005372324

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The Tohoku Journal of Experimental
… However, TLRs are also expressed in cancer cells, including melanoma cells, which express TLR2-4. … therefore, we assessed the expression of TLR4 in human melanoma specimens (29 primary lesions and 28 metastatic lesions) representing different types of melanoma. … A high percentage (≥ 90%) of melanoma lesions expressed TLR4, as judged by immunohistochemistry. …
NAID 130004685014

Experimental and Analytical Studies on Contact Irreversible Electroporation for Superficial Tumor Treatment

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Journal of Biomechanical Science and Engineering 8(4), 306-318, 2013
… In this study, we demonstrated that the IRE is also applicable to treat superficial targets such as melanoma, nevus, and tumors on gastrointestinal surface. …
NAID 130003384005