- 伸長・リグルタミン鎖
WordNet
- make bigger or wider in size, volume, or quantity; "expand the house by adding another wing"
- become larger in size or volume or quantity; "his business expanded rapidly"
- extend in one or more directions; "The dough expands" (同)spread out
- a brief treatise on a subject of interest; published in the form of a booklet (同)pamphlet
- an extended area of land (同)piece of land, piece of ground, parcel of land, parcel
- a system of body parts that together serve some particular purpose
- a drawing created by superimposing a semitransparent sheet of paper on the original image and copying on it the lines of the original image (同)trace
- the act of drawing a plan or diagram or outline
- the discovery and description of the course of development of something; "the tracing of genealogies"
- increased in extent or size or bulk or scope
PrepTutorEJDIC
- (…にまで)『拡大する』,膨張する,広がる《+『into』+『名』》 / (…について)さらに詳しく述べる《+『on』(『upon』)+『名』》 / 〈人が〉打ち解ける,心を開く / …‘を'『拡大する』,拡張する,広げる;…‘を'拡大して(…に)する《+『名』+『into』+『名』》
- 広大な土地(地域),(土地・海・空などの)広がり《+of+名》 / (器官の)管,(神経の)索
- (おもに宗教・政治などの宣伝用の)小冊子,パンフレット
- 跡を追うこと,追跡;透写,複写 / 〈C〉 / 透写(複写)によってできたもの(地図・図案など),透写図
UpToDate Contents
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- 1. ハンチントン病：遺伝学と病因 huntington disease genetics and pathogenesis
- 2. 脊髄小脳変性症 the spinocerebellar ataxias
- 3. ハンチントン病：臨床的特徴および診断 huntington disease clinical features and diagnosis
- 4. 小児における運動減少性運動障害 bradykinetic movement disorders in children
- 5. アンドロゲン受容体障害の病因および臨床症状 pathogenesis and clinical manifestations of disorders of androgen action
English Journal
- Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington's disease.
- Nithianantharajah J, Hannan AJ.SourceCentre for Clinical Brain Sciences & Centre for Neuroregeneration, Chancellor's Building, University of Edinburgh, United Kingdom.
- Neuroscience.Neuroscience.2012 May 24. [Epub ahead of print]
- Huntington's disease (HD) is an autosomal dominant tandem repeat expansion disorder involving cognitive, psychiatric and motor symptoms. The expanded trinucleotide (CAG) repeat leads to an extended polyglutamine tract in the huntingtin protein and a subsequent cascade of molecular and cellular patho
- PMID 22633949
- Mass Spectrometric Identification of Novel Posttranslational Modification Sites in Huntingtin.
- Dong G, Callegari E, Gloeckner CJ, Ueffing M, Wang H.SourceDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
- Proteomics.Proteomics.2012 May 23. doi: 10.1002/pmic.201100380. [Epub ahead of print]
- Huntington's disease (HD) is caused by a CAG triplet repeat expansion in exon 1 of the Huntingtin (Htt) gene, encoding an abnormal expanded polyglutamine (polyQ) tract that confers toxicity to the mutant Htt (mHtt) protein. Recent data suggest that posttranslational modifications of mHtt modulate it
- PMID 22623107
Japanese Journal
- 球脊髄性筋萎縮症（SBMA）に対する抗アンドロゲン療法
- 勝野 雅央,坂野 晴彦,鈴木 啓介,橋詰 淳,足立 弘明,田中 章景,祖父江 元
- 臨床神経学 52(11), 1207-1209, 2012
- 球脊髄性筋萎縮症（SBMA）はアンドロゲン受容体（AR）遺伝子におけるCAGくりかえし塩基配列の異常延長を原因とする運動ニューロン疾患であり，伸長ポリグルタミン鎖を有する異常AR蛋白質がテストステロンと結合することによってニューロンの核内に蓄積することが病態の本質と考えられている．テストステロンの分泌を抑制するリュープロレリン酢酸塩のSBMAに対する第III相臨床試験では，主要評価項目である咽頭部 …
- NAID 130004505107
- Naringenin Inhibits the Aggregation of Expanded Polyglutamine Tract-Containing Protein through the Induction of Endoplasmic Reticulum Chaperone GRP78
- , , [他],
- Biological and Pharmaceutical Bulletin 35(10), 1836-1840, 2012
- … Polyglutamine (polyQ) diseases are inherited neurodegenerative diseases characterized by the aggregation of proteins containing expanded polyQ tract. …
- NAID 130001872378
- Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract
- KOBAYASHI Y.
- J Biol Chem 275, 8772-8778, 2000
- NAID 80011573998
Related Links
- During protein synthesis, the expanded CAG repeats are translated into a series of uninterrupted glutamine residues forming what is known as a polyglutamine tract ("polyQ"). Such polyglutamine tracts may be subject to increased aggregation ...
- One might envisage two possible mechanisms for the pathogenic effects of an expanded polyglutamine tract: (1) a ... For each disease, the pathogenic effect of the expanded polyglutamine tract is a gain-of-function dominant phenotype usually ...
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★リンクテーブル★
| リンク元 | 「伸長ポリグルタミン鎖」 |
| 関連記事 | 「expand」「tracing」「tract」 |
「伸長ポリグルタミン鎖」
「expand」
- v.
- 拡大する、膨張する、広がる、発展する、(ペプチド鎖などが)伸長する
- 関
- develop、development、dilatation、dilate、dilation、distend、distention、elongate、elongation、enlarge、enlargement、evolution、expansion、extend、extension、inflate、inflation、magnify、outgrowth、spread、stretch、swell、swelling
「tracing」
- n.
「tract」
- n.
- 関
- tractus