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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/06/08 08:31:25」(JST)

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  • Up-regulation of brain-enriched miR-107 promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke.
  • Yang ZB1, Zhang Z2, Li TB1, Lou Z1, Li SY2, Yang H2, Yang J2, Luo XJ, Peng J.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2014 Dec;127(12):679-89. doi: 10.1042/CS20140084.
  • Recent studies have uncovered that accumulation of glutamate after ischaemic stroke is closely associated with the down-regulation of glutamate transporter-1 (GLT-1) expression, suggesting that GLT-1 expression critically controls glutamate accumulation and the abnormal glutamate transport-elicited
  • PMID 24943094
  • White matter injury: Ischemic and nonischemic.
  • Fern RF1, Matute C, Stys PK.
  • Glia.Glia.2014 Nov;62(11):1780-9. doi: 10.1002/glia.22722. Epub 2014 Jul 18.
  • Ischemic pathologies of white matter (WM) include a large proportion of stroke and developmental lesions while multiple sclerosis (MS) is the archetype nonischemic pathology. Growing evidence suggests other important diseases including neurodegenerative and psychiatric disorders also involve a signi
  • PMID 25043122
  • IGF-1 alleviates NMDA-induced excitotoxicity in cultured hippocampal neurons against autophagy via the NR2B/PI3K-AKT-mTOR pathway.
  • Wang Y1, Wang W, Li D, Li M, Wang P, Wen J, Liang M, Su B, Yin Y.
  • Journal of cellular physiology.J Cell Physiol.2014 Nov;229(11):1618-29. doi: 10.1002/jcp.24607.
  • Insulin-like growth factor-1 (IGF-1) is a brain-specific multifunctional protein involved in neuronal polarity and axonal guidance. Mature IGF-1 triggers three enzymes, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and phosphoinositide phospholipase C-γ (PLC-γ), wh
  • PMID 24604717


  • Korean Red Ginseng Extract Exhibits Neuroprotective Effects through Inhibition of Apoptotic Cell Death
  • Kim Sunyoung,Lee Youngmoon,Cho Jungsook
  • Biological & pharmaceutical bulletin 37(6), 938-946, 2014-06
  • NAID 40020073540
  • チアミン(ビタミンB1)欠乏による神経組織障害
  • 濱田 俊
  • 比較生理生化学 31(1), 13-19, 2014
  • チアミン(ビタミンB1)はエネルギー代謝に不可欠の補酵素であり,その欠乏は神経系に特有の障害を引き起こす。ヒトでは2種類のチアミン欠乏症,脚気とWernicke-Korsakoff症候群(WKS)がみられるが,脚気では主に末梢神経系が障害される一方,WKSでは中枢神経系が障害される。なぜ単一のビタミンが異なる2種類の病態を引き起こすのかよくわかっていない。WKSの神経組織障害は,多くの神経変性疾患 …
  • NAID 130003394319
  • 虚血性脳障害におけるプロスタグランジンE2の役割
  • 松尾(池田) 由理
  • YAKUGAKU ZASSHI 133(9), 947-954, 2013
  • … In mPGES-1 KO slices, glutamate-induced excitotoxicity was less severe compared to that in WT slices. … Among the EP1-4 antagonists and agonists, only the EP3 antagonist attenuated and only the EP3 agonist augmented the glutamate-induced excitotoxicity. …
  • NAID 130003361986


Excitotoxicity Excitotoxicity 細胞死が作り出されるプロセスはある ニューロン excitatory のoveractivation によって 神経伝達物質 のような受容器 NMDA の受容器 そして AMPA の受容器。 Excitotoxins は好む NMDA そして kainic 酸 結合 ...
Excitotoxicity. 32 likes · 0 talking about this. Excitotoxicity is the pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This ...


Research Express@NCKU - Articles Digest glutamate transporters - get domain Mai blog: nmda receptorExcitotoxicity - Wikipedia, the free Neuroprotective and symptomatic effects of Excitotoxicity by Nurse With Wound/Graham




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