excitatory amino acid transporter 4

興奮性アミノ酸トランスポーター4、4型興奮性アミノ酸輸送体

関

EAAT4

WordNet

1. move something or somebody around; usually over long distances
2. an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
3. move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
4. transport commercially (同)send, ship
5. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
6. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
7. having the characteristics of an acid; "an acid reaction"
8. a long truck for carrying motor vehicles (同)car transporter
9. a crane for moving material with dispatch as in loading and unloading ships
10. pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
11. the radical -NH2 (同)amino_group

PrepTutorEJDIC

1. (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
2. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
3. 自動車運搬用大型トラック

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/30 14:44:29」(JST)

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SLC1A6
Identifiers
Aliases	SLC1A6, EAAT4
External IDs	OMIM: 600637 MGI: 1096331 HomoloGene: 21055 GeneCards: 6511
Gene ontology Molecular function • L-aspartate transmembrane transporter activity • symporter activity • L-glutamate transmembrane transporter activity • sodium:dicarboxylate symporter activity Cellular component • integral component of membrane • Golgi apparatus • membrane • plasma membrane • integral component of plasma membrane • presynapse Biological process • synaptic transmission • dicarboxylic acid transport • regulation of membrane potential • ion transport • glutamate secretion • transmembrane transport • L-glutamate transmembrane transport • transport • aspartate transport • neurotransmitter secretion • L-glutamate transport • L-aspartate transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6511	20513
Ensembl	ENSG00000105143	ENSMUSG00000005357
UniProt	P48664	O35544
RefSeq (mRNA)	NM_001272087 NM_001272088 NM_005071	NM_009200
RefSeq (protein)	NP_001259016.1 NP_001259017.1 NP_005062.1	NP_033226.1
Location (UCSC)	Chr 19: 14.95 – 15.02 Mb	Chr 10: 78.78 – 78.81 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human		View/Edit Mouse

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.

References

Further reading

• Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID 17221839. 
• Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168. 
• Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4.". J. Physiol. (Lond.) 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC 2278676. PMID 11432999. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits.". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC 2435202. PMID 17360917. 
• Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.". Nature 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047. 
• Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase.". J. Neurochem. 102 (3): 858–66. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044. 
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 

UpToDate Contents

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• 1. 遺伝性運動失調の概要 overview of the hereditary ataxias
• 2. 先天性代謝異常：分類 inborn errors of metabolism classification
• 3. 尿素サイクル障害：臨床的特徴および診断 urea cycle disorders clinical features and diagnosis
• 4. 先天性代謝異常：代謝性救急疾患 inborn errors of metabolism metabolic emergencies
• 5. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children

English Journal

• Molecular identification and cellular localization of a potential transport system involved in cystine/cysteine uptake in human lenses.

• Lim JC1, Lam L, Li B, Donaldson PJ.
• Experimental eye research.Exp Eye Res.2013 Nov;116:219-26. doi: 10.1016/j.exer.2013.09.002. Epub 2013 Sep 19.
• In this study we have sought to identify whether cystine uptake mechanisms previously identified in the rat lens are also found in the human lens. Using a combination of reverse transcriptase PCR, Western blotting and immunohistochemistry, we show that the light chain subunit of the cystine/glutamat
• PMID 24056007

• Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.

• Wilmsdorff MV1, Blaich C, Zink M, Treutlein J, Bauer M, Schulze T, Schneider-Axmann T, Gruber O, Rietschel M, Schmitt A, Falkai P.
• The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.World J Biol Psychiatry.2013 Sep;14(7):490-9. doi: 10.3109/15622975.2011.645877. Epub 2012 Mar 16.
• OBJECTIVES: The glutamatergic hypothesis of schizophrenia proposes alterations of excitatory amino acid transporters (solute carrier family, SLCs) expression and cerebellar dysfunctions. The influence of the neuregulin-1 (NRG1) risk genotype or effects of antipsychotics on expression of EAATs are un
• PMID 22424243

• Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4.

• Almilaji A1, Munoz C, Pakladok T, Alesutan I, Feger M, Föller M, Lang UE, Shumilina E, Lang F.
• PloS one.PLoS One.2013 Jul 29;8(7):e70988. doi: 10.1371/journal.pone.0070988. Print 2013.
• Klotho, a transmembrane protein, which can be cleaved off as β-glucuronidase and hormone, is released in both, kidney and choroid plexus and encountered in blood and cerebrospinal fluid. Klotho deficiency leads to early appearance of age-related disorders and premature death. Klotho may modify tran
• PMID 23923038

Japanese Journal

• Functional Expression of Organic Ion Transporters in Astrocytes and Their Potential as a Drug Target in the Treatment of Central Nervous System Diseases

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 40(8), 1153-1160, 2017
• NAID 130005876330

• Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood–Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina

• Biological and Pharmaceutical Bulletin 38(7), 1087-1091, 2015
• NAID 130005086298

• <i>In Vitro</i> Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine–Serine–Cysteine Transporter 2

• Biological and Pharmaceutical Bulletin 38(6), 901-908, 2015
• NAID 130005072672

Related Links

• Excitatory amino acid transporter 4 - definition of Excitatory ...

SLC1A6 SLC1A6 A gene on chromosome 19p13.12 that encodes an amino acid (L-glutamate and L- and D-aspartate) transporter and sodium co-transporter.

• Excitatory Amino Acid Transporter 4 - RightDiagnosis.com

Excitatory Amino Acid Transporter 4 information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Excitatory Amino Acid Transporter 4 Description of Excitatory ...

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★リンクテーブル★

リンク元	「EAAT4」「4型興奮性アミノ酸輸送体」「興奮性アミノ酸トランスポーター4」「SLC1A6」
関連記事	「transport」「excitatory」「transporter」

「EAAT4」

　　[★]

• 興奮性アミノ酸トランスポーター4、4型興奮性アミノ酸輸送体

関

excitatory amino acid transporter 4

「4型興奮性アミノ酸輸送体」

　　[★]

英

excitatory amino acid transporter 4、EAAT4

関

興奮性アミノ酸トランスポーター4

「興奮性アミノ酸トランスポーター4」

　　[★]

英

excitatory amino acid transporter 4、EAAT4

関

4型興奮性アミノ酸輸送体

「SLC1A6」

　　[★]

• excitatory amino acid transporter 4

「transport」

　　[★]

• n.

• 輸送、運搬

• v.

• 輸送する、運搬する、運ぶ

関

bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

　 　 　 　 　

「excitatory」

　　[★]

• 興奮性の、興奮の

関

excitability、excitable、excitation、excite、excitement、exciting、excito、fire

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein