excitatory amino acid antagonist

• 興奮性アミノ酸遮断薬、興奮性アミノ酸アンタゴニスト

関

glutamate antagonist、glutamate receptor antagonist

WordNet

1. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
2. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
3. having the characteristics of an acid; "an acid reaction"
4. a drug that neutralizes or counteracts the effects of another drug
5. a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
6. pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
7. the radical -NH2 (同)amino_group

PrepTutorEJDIC

1. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
2. 対立する人,敵対者,競争相手(opponent)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/26 04:06:48」(JST)

wiki en

[Wiki en表示]

An excitatory amino acid receptor antagonist, or glutamate receptor antagonist, is a chemical substance which antagonizes one or more of the glutamate receptors.

Examples include:

• AP5
• Barbiturates
• Dextromethorphan
• Dextrorphan
• Dizocilpine
• Ethanol
• Ibogaine
• Ifenprodil
• Ketamine
• Kynurenic acid
• Memantine
• Nitrous oxide
• Perampanel
• Phencyclidine

See also

• Excitatory amino acid receptor agonist
• Excitatory amino acid reuptake inhibitor
• N-methyl-D-aspartate receptor antagonist

External links

• MeSH list of agents 82018691

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. フェニルケトン尿症の概要 overview of phenylketonuria
• 2. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children
• 3. 肝性脳症：病因 hepatic encephalopathy pathogenesis
• 4. 痙攣発作およびてんかんの病態生理 pathophysiology of seizures and epilepsy
• 5. 先天性代謝異常：分類 inborn errors of metabolism classification

English Journal

• Altered nociception in mice with genetically induced hypoglutamatergic tone.

• Kayser V1, Viguier F1, Melfort M1, Bourgoin S2, Hamon M2, Masson J3.
• Neuroscience.Neuroscience.2015 May 7;293:80-91. doi: 10.1016/j.neuroscience.2015.02.044. Epub 2015 Mar 2.
• Extensive pharmacological evidence supports the idea that glutamate plays a key role in both acute and chronic pain. In the present study, we investigated the implication of the excitatory amino acid in physiological nociception by using mutant mice deficient in phosphate-activated glutaminase type
• PMID 25743253

• Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and "depressed" mice exposed to chronic mild stress.

• Franceschelli A1, Sens J1, Herchick S1, Thelen C1, Pitychoutis PM2.
• Neuroscience.Neuroscience.2015 Apr 2;290:49-60. doi: 10.1016/j.neuroscience.2015.01.008. Epub 2015 Jan 14.
• During the past decade, one of the most striking discoveries in the treatment of major depression was the clinical finding that a single infusion of a sub-anesthetic dose of the N-methyl-d-aspartate receptor antagonist ketamine produces a rapid (i.e. within a few hours) and long-lasting (i.e. up to
• PMID 25595985

• Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene.

• Beckley JT1, Randall PK, Smith RJ, Hughes BA, Kalivas PW, Woodward JJ.
• Addiction biology.Addict Biol.2015 Mar 6. doi: 10.1111/adb.12235. [Epub ahead of print]
• Abused inhalants are voluntarily inhaled at high concentrations to produce intoxicating effects. Results from animal studies show that the abused inhalant toluene triggers behaviors, such as self-administration and conditioned place preference, which are commonly associated with addictive drugs. How
• PMID 25752326

Japanese Journal

• 15 グルタミン酸海洋天然物の類縁体合成とAMPA受容体阻害剤の創製(口頭発表の部)

• 天然有機化合物討論会講演要旨集 (52), 85-90, 2010-09-01
• NAID 110009757739

• 骨組織における機能的グルタミン酸シグナリング

• YAKUGAKU ZASSHI 130(9), 1175-1179, 2010
• NAID 130000342377

• 25 ダイシハーベイン構造類縁体を結合したグルタミン酸受容体の結晶構造解析(口頭発表の部)

• 天然有機化合物討論会講演要旨集 (50), 173-178, 2008-09-01
• NAID 110007066761

Related Links

• excitatory amino acid antagonist (CHEBI:60798)

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. ... ChEBI Name excitatory amino acid antagonist ChEBI ...

• Clinical Experience With Excitatory Amino Acid Antagonist Drugs

Abstract Background Excitotoxic damage due to excess release of neuronal glutamate is hypothesized to play a pivotal role in the pathogenesis of focal cerebral ischemia. Drugs that antagonize excitatory amino acid ...

---

★リンクテーブル★

リンク元	「glutamate antagonist」「興奮性アミノ酸遮断薬」「興奮性アミノ酸アンタゴニスト」「glutamate receptor antagonist」
関連記事	「excitatory」

「glutamate antagonist」

　　[★]

• グルタミン酸受容体遮断薬、グルタミン酸遮断薬、グルタミン酸拮抗薬

関

excitatory amino acid antagonist、glutamate receptor antagonist

「興奮性アミノ酸遮断薬」

　　[★]

英

excitatory amino acid antagonist

関

興奮性アミノ酸アンタゴニスト、グルタミン酸拮抗薬、グルタミン酸受容体遮断薬

「興奮性アミノ酸アンタゴニスト」

　　[★]

英

excitatory amino acid antagonist

関

グルタミン酸拮抗薬、興奮性アミノ酸遮断薬、グルタミン酸受容体遮断薬

「glutamate receptor antagonist」

　　[★]

• グルタミン酸受容体遮断薬、グルタミン酸受容体拮抗薬

関

excitatory amino acid antagonist、glutamate antagonist

「excitatory」

　　[★]

• 興奮性の、興奮の

関

excitability、excitable、excitation、excite、excitement、exciting、excito、fire