excitation-contraction coupling

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英文文献

  • Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review).
  • Yamaguchi M.Author information Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.AbstractRegucalcin was first identified in 1978 as a regulatory protein of Ca2+ signaling in liver cells. Regucalcin was shown to play a multifunctional role in cell regulation, such as maintainance of intracellular Ca2+ homeostasis and suppression of signal transduction, protein synthesis, nuclear function, cell proliferation and apoptosis in various types of cells and tissues. Cardiac excitation-contraction coupling is based on the regulation of intracellular Ca2+ concentration by the Ca2+ pump in the sarcoplasmic reticulum of heart muscle cells. Regucalcin, which is expressed in the heart, was found to increase rat heart sarcoplasmic reticulum Ca2+-ATPase activity and ATP-dependent Ca2+ uptake and mitochondrial Ca2+-ATPase activity. Regucalcin was also shown to suppress Ca2+-dependent protein tyrosine phosphatase, Ca2+/calmodulin-dependent protein phosphatase (calcineurin) and nitric oxide (NO) synthase activity in the heart cytoplasm. Moreover, regucalcin was found to activate superoxide dismutase (SOD), which plays a significant role in the prevention of cell death and apoptosis in the heart. Regucalcin may be a key molecule in heart muscle cell regulation through Ca2+ signaling. Regucalcin may also play a pathophysiological role in heart failure. The aim of this study was to review the recent findings regarding the role of regucalcin in Ca2+ signaling in the heart.
  • Biomedical reports.Biomed Rep.2014 May;2(3):303-308. Epub 2014 Mar 5.
  • Regucalcin was first identified in 1978 as a regulatory protein of Ca2+ signaling in liver cells. Regucalcin was shown to play a multifunctional role in cell regulation, such as maintainance of intracellular Ca2+ homeostasis and suppression of signal transduction, protein synthesis, nuclear function
  • PMID 24748964
  • Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake.
  • Tewari SG1, Camara AK, Stowe DF, Dash RK.Author information 1Biotechnology and Bioengineering Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-6509, USA. rdash@mcw.edu.AbstractCardiac mitochondria can act as a significant Ca2+ sink and shape cytosolic Ca2+ signals affecting various cellular processes, such as energy metabolism and excitation-contraction coupling. However, different mitochondrial Ca2+ uptake mechanisms are still not well understood. In this study, we analysed recently published Ca2+ uptake experiments performed on isolated guinea pig cardiac mitochondria using a computer model of mitochondrial bioenergetics and cation handling. The model analyses of the data suggest that the majority of mitochondrial Ca2+ uptake, at physiological levels of cytosolic Ca2+ and Mg2+, occurs through a fast Ca2+ uptake pathway, which is neither the Ca2+ uniporter nor the rapid mode of Ca2+ uptake. This fast Ca2+ uptake component was explained by including a biophysical model of the ryanodine receptor (RyR) in the computer model. However, the Mg2+-dependent enhancement of the RyR adaptation was not evident in this RyR-type channel, in contrast to that of cardiac sarcoplasmic reticulum RyR. The extended computer model is corroborated by simulating an independent experimental dataset, featuring mitochondrial Ca2+ uptake, egress and sequestration. The model analyses of the two datasets validate the existence of two classes of Ca2+ buffers that comprise the mitochondrial Ca2+ sequestration system. The modelling study further indicates that the Ca2+ buffers respond differentially depending on the source of Ca2+ uptake. In particular, it suggests that the Class 1 Ca2+ buffering capacity is auto-regulated by the rate at which Ca2+ is taken up by mitochondria.
  • The Journal of physiology.J Physiol.2014 May 1;592(Pt 9):1917-1930. Epub 2014 Mar 3.
  • Cardiac mitochondria can act as a significant Ca2+ sink and shape cytosolic Ca2+ signals affecting various cellular processes, such as energy metabolism and excitation-contraction coupling. However, different mitochondrial Ca2+ uptake mechanisms are still not well understood. In this study, we analy
  • PMID 24591571

和文文献

  • β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
  • Kashihara Toshihide,Hirose Masamichi,Shimojo Hisashi,Nakada Tsutomu,Gomi Simmon,Hongo Minoru,Yamada Mitsuhiko
  • EUROPEAN JOURNAL OF PHARMACOLOGY 724, 122-131, 2014-02-05
  • … L-Lype Ca2+ channels (LTCC) play a crucial role in cardiac excitation-contraction coupling. …
  • NAID 120005440173
  • 幼少期の心機能を制御する新しいCa2+ 調節タンパク質の発見とその分子機構
  • 中村(西谷) 友重,若林 繁夫
  • 日本小児循環器学会雑誌 30(3), 224-231, 2014
  • 心臓の収縮や心肥大・心不全の発症を調節するものとして,細胞内カルシウム(Ca2+)の増減が重要なカギとなっている.しかし,胎児期や幼少期などの未成熟期の心臓では,細胞内Ca2+貯蔵装置である筋小胞体(SR)の構造が成体と比べはるかに未発達であることから,どのようにCa2+による収縮調節を行っているのか不明な点が多かった.今回,特に未成熟期の心臓に高発現するCa2+結合タンパク質(Neuronal …
  • NAID 130004879017

関連リンク

Excitation Contraction Coupling Like most excitable cells, muscle fibers respond to the excitation signal with a rapid depolarization which is coupled with its physiological response: contraction. Cellular Resting Potential If we ...
Although hormonal and biochemical changes play a vital role in regulating and developing conditions leading to labor, the speed and coordination of a process called excitation-contraction coupling in uterine muscle tissue indicate that ...

関連画像

 12-11a: Excitation-contraction couplingExcitation-Contraction CouplingExcitation-Contraction Coupling Figure 9 Excitation-Contraction Couplingmaxresdefault.jpgExcitation Contraction Coupling


★リンクテーブル★
リンク元EC coupling
関連記事contraction」「coupling」「excitation

EC coupling」

  [★] 興奮収縮連関 excitation-contraction coupling


contraction」

  [★]

  • n.
  • 短縮、収縮。(筋肉の)収縮、攣縮。(医)(腎・肝・膀胱などの)萎縮
  • 縮小。制限。(通貨・資金などの)制限、回収、縮小。不況
  • (数)縮小、縮約。省略算。(文法)縮約、短縮
  • 負債を作ること、病気にかかること、癖のつくこと
  • 交わり/約束を結ぶこと(of)


WordNet   license wordnet

「(physiology) a shortening or tensing of a part or organ (especially of a muscle or muscle fiber)」
muscular contraction, muscle contraction

WordNet   license wordnet

「the act of decreasing (something) in size or volume or quantity or scope」

WordNet   license wordnet

「a word formed from two or more words by omitting or combining some sounds; "`won''t'' is a contraction of `will not''"; "`o''clock'' is a contraction of `of the clock''"」

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉(…の)収縮,短縮《+『of』+『名』》 / 〈U〉(通貨・資金・支出などの)縮小,節減《+『of』+『名』》 / 〈U〉(いやなこと・よくないことを)身に負うこと,(悪習などが)身につくこと《+『of』+『名』》 / 〈C〉陣痛」


coupling」

  [★]

associationconjugateconjugatedconjugationcouplelinkage

WordNet   license wordnet

「a mechanical device that serves to connect the ends of adjacent objects」
coupler

WordNet   license wordnet

「the act of pairing a male and female for reproductive purposes; "the casual couplings of adolescents"; "the mating of some species occurs only in the spring"」
mating, pairing, conjugation, union, sexual union

PrepTutorEJDIC   license prepejdic

「〈U〉連結,結合 / =coupler / 〈U〉〈C〉(電気回路の)結合」


excitation」

  [★]

  • n.
excitatoryexciteexcitementexcitingfire

WordNet   license wordnet

「the neural or electrical arousal of an organ or muscle or gland」
innervation, irritation

WordNet   license wordnet

「something that agitates and arouses; "he looked forward to the excitements of the day"」
excitement




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