真核細胞ト・イソメラーゼII

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Chromatin regulates DNA torsional energy via topoisomerase II-mediated relaxation of positive supercoils.

Fernández X1, Díaz-Ingelmo O1, Martínez-García B1, Roca J2.
The EMBO journal.EMBO J.2014 Jul 1;33(13):1492-501. doi: 10.15252/embj.201488091. Epub 2014 May 23.
Eukaryotic topoisomerases I (topo I) and II (topo II) relax the positive (+) and negative (-) DNA torsional stress (TS) generated ahead and behind the transcription machinery. It is unknown how this DNA relaxation activity is regulated and whether (+) and (-)TS are reduced at similar rates. Here, we
PMID 24859967

Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response.

Poulsen KL1, Olivero-Verbel J1, Beggs KM1, Ganey PE1, Roth RA2.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2014 Jul;350(1):164-70. doi: 10.1124/jpet.114.214189. Epub 2014 May 9.
Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In a murine model of IDILI, otherwise nontoxic doses of TVX and the inflammagen lipopolysaccharide (LPS) interacted to produce pronounced hepatocellular injury. The liver injury depended on a TV
PMID 24817034

Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

Gao R1, Schellenberg MJ2, Huang SY1, Abdelmalak M1, Marchand C1, Nitiss KC3, Nitiss JL3, Williams RS2, Pommier Y4.
The Journal of biological chemistry.J Biol Chem.2014 Jun 27;289(26):17960-9. doi: 10.1074/jbc.M114.565374. Epub 2014 May 7.
Eukaryotic type II topoisomerases (Top2α and Top2β) are homodimeric enzymes; they are essential for altering DNA topology by the formation of normally transient double strand DNA cleavage. Anticancer drugs (etoposide, doxorubicin, and mitoxantrone) and also Top2 oxidation and DNA helical alteratio
PMID 24808172

Inhibitory effect of coenzyme Q_1 on eukaryotic DNA polymerase γ and DNA topoisomerase II activities on the growth of a human cancer cell line

YONEZAWA Yuko,KURIYAMA Isoko,FUKUOH Atsushi,MUTA Tsuyoshi,KANG Dongchon,TAKEMURA Masaharu,KATO Ikuo,YOSHIDA Hiromi,MIZUSHINA Yoshiyuki
Cancer science 97(8), 716-723, 2006-08-10
NAID 10018768119

Inhibition of Topoisomerase II α Subunit De Novo Synthesis by Specific Antisense Oligonucleotides Suppresses Human Gliomo T98G Cell Growth

申正樹,KIMURA Shoji,NAGAO Seigo
Neurologia medico-chirurgica 39(3), 199-205, 1999-03-15
… 本実験では様々な抗ガン剤の標的酵素とされるトボイソメラーゼIIに対するアンチセンスオリゴヌクレオタイドを用いて、T98Gヒトグリオーマ培養細胞の増殖を抑制し、その際トボイソメラーゼII酵素活性は低下しトポイソメラーゼI酵素活性は増強される傾向にあることを確かめた。 …
NAID 110002279734